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Role of Th1/Th2 cytokines in the diagnosis and prognostic evaluation of ankylosing spondylitis.

Abstract Ankylosing spondylitis (AS), a progressive disease of the spine, manifests as peripheral arthritis with tendon and ligament inflammation that restricts activity. AS is a rheumatoid autoimmune disease although the rheumatoid factor is absent in patients with AS. It is characterized by inflammatory changes such as elevated levels of serum inflammatory factors. The roles of Th1 and Th2 cytokines in autoimmune diseases are well known. However, the roles of these cytokines in the diagnosis and prognosis of AS is poorly understood. The aim of this study was to investigate the roles of Th1/Th2 cytokines in the diagnosis and prognosis of AS. The BASDAI activity, BASFI functional index, BASMI measurement score, and the levels of CRP and ESR were measured during the treatment of patients with active AS. The levels of IFN-γ and TNF-α (Th1 cytokines) and IL-4 and IL-10 (Th2 cytokines) were quantified. The levels of IL-4 and IL-10 were significantly low in the serum of patients with active AS, who also had high IFN-γ and TNF-α levels compared to those in the control individuals (P < 0.05). After treatment, the levels of IL-4 and IL-10 increased while those of IFN-γ and TNF-α decreased compared to those in individuals with active AS (P < 0.05). The disease activity index correlated positively with levels of IFN-γ and TNF-α and negatively with levels of IL-4 and IL-10, but not with that of CRP or ESR. Changes in the levels of Th1/2 cytokines in patients with AS may reflect disease activity and prognosis.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title genetics and molecular research : gmr
Publication Year Start




PMID- 28362980
OWN - NLM
STAT- MEDLINE
DA  - 20170331
DCOM- 20170406
LR  - 20170406
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 16
IP  - 1
DP  - 2017 Mar 16
TI  - Role of Th1/Th2 cytokines in the diagnosis and prognostic evaluation of
      ankylosing spondylitis.
LID - 10.4238/gmr16019322 [doi]
AB  - Ankylosing spondylitis (AS), a progressive disease of the spine, manifests as
      peripheral arthritis with tendon and ligament inflammation that restricts
      activity. AS is a rheumatoid autoimmune disease although the rheumatoid factor is
      absent in patients with AS. It is characterized by inflammatory changes such as
      elevated levels of serum inflammatory factors. The roles of Th1 and Th2 cytokines
      in autoimmune diseases are well known. However, the roles of these cytokines in
      the diagnosis and prognosis of AS is poorly understood. The aim of this study was
      to investigate the roles of Th1/Th2 cytokines in the diagnosis and prognosis of
      AS. The BASDAI activity, BASFI functional index, BASMI measurement score, and the
      levels of CRP and ESR were measured during the treatment of patients with active 
      AS. The levels of IFN-gamma and TNF-alpha (Th1 cytokines) and IL-4 and IL-10 (Th2
      cytokines) were quantified. The levels of IL-4 and IL-10 were significantly low
      in the serum of patients with active AS, who also had high IFN-gamma and
      TNF-alpha levels compared to those in the control individuals (P &lt; 0.05). After
      treatment, the levels of IL-4 and IL-10 increased while those of IFN-gamma and
      TNF-alpha decreased compared to those in individuals with active AS (P &lt; 0.05).
      The disease activity index correlated positively with levels of IFN-gamma and
      TNF-alpha and negatively with levels of IL-4 and IL-10, but not with that of CRP 
      or ESR. Changes in the levels of Th1/2 cytokines in patients with AS may reflect 
      disease activity and prognosis.
FAU - Wen, J T
AU  - Wen JT
AD  - Department of Orthopedics, TCM Hospital of Gansu Province, Lanzhou, Gansu, China.
FAU - Zhang, D H
AU  - Zhang DH
AD  - Department of Orthopedics, TCM Hospital of Gansu Province, Lanzhou, Gansu, China 
      [email protected]
FAU - Fang, P F
AU  - Fang PF
AD  - Department of Orthopedics, the Baiyin branch of TCM Hospital of Gansu Province,
      Lanzhou, Gansu, China.
FAU - Li, M H
AU  - Li MH
AD  - Department of Orthopedics, the Baiyin branch of TCM Hospital of Gansu Province,
      Lanzhou, Gansu, China.
FAU - Wang, R J
AU  - Wang RJ
AD  - Department of Orthopedics, the Baiyin branch of TCM Hospital of Gansu Province,
      Lanzhou, Gansu, China.
FAU - Li, S H
AU  - Li SH
AD  - Department of Orthopedics, TCM Hospital of Gansu Province, Lanzhou, Gansu, China.
LA  - eng
PT  - Journal Article
DEP - 20170316
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Cytokines)
RN  - 0 (IL10 protein, human)
RN  - 0 (IL4 protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anti-Inflammatory Agents, Non-Steroidal/*administration &amp; dosage/therapeutic use
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Interferon-gamma/blood
MH  - Interleukin-10/blood
MH  - Interleukin-4/blood
MH  - Male
MH  - Prognosis
MH  - Severity of Illness Index
MH  - Spondylitis, Ankylosing/blood/*diagnosis/*drug therapy/immunology
MH  - Th1 Cells/*immunology
MH  - Th2 Cells/*immunology
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Young Adult
EDAT- 2017/04/01 06:00
MHDA- 2017/04/07 06:00
CRDT- 2017/04/01 06:00
AID - gmr-16-01-gmr.16019322 [pii]
AID - 10.4238/gmr16019322 [doi]
PST - epublish
SO  - Genet Mol Res. 2017 Mar 16;16(1). doi: 10.4238/gmr16019322.

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