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Blood markers of fibrinolysis and endothelial activation in canine babesiosis.

Abstract Canine babesiosis is a tick-borne disease caused by hemoprotozoan parasites of the genus Babesia. The disease can be clinically classified into uncomplicated and complicated forms. The aim of this study was to assess the level of endothelial activation and alterations in the fibrinolytic pathway during canine babesiosis.
PMID
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Authors

Mayor MeshTerms

Fibrinolysis

Keywords

Biomarkers

Hemostasis

Vascular Endothelium

Journal Title bmc veterinary research
Publication Year Start




PMID- 28363279
OWN - NLM
STAT- MEDLINE
DA  - 20170401
DCOM- 20170406
LR  - 20170406
IS  - 1746-6148 (Electronic)
IS  - 1746-6148 (Linking)
VI  - 13
IP  - 1
DP  - 2017 Mar 31
TI  - Blood markers of fibrinolysis and endothelial activation in canine babesiosis.
PG  - 82
LID - 10.1186/s12917-017-0995-6 [doi]
AB  - BACKGROUND: Canine babesiosis is a tick-borne disease caused by hemoprotozoan
      parasites of the genus Babesia. The disease can be clinically classified into
      uncomplicated and complicated forms. The aim of this study was to assess the
      level of endothelial activation and alterations in the fibrinolytic pathway
      during canine babesiosis. RESULTS: Blood samples were collected on the day of
      admission and on the 6th day after treatment with imidocarb propionate, from 30
      dogs of various breeds and of both sexes with naturally occurring babesiosis
      caused by B. canis. In this prospective study, plasminogen activity was assessed 
      using a chromogenic assay, and concentrations of high mobility group box-1
      protein (HMGB-1), intercellular adhesive molecule-1 (ICAM-1), vascular adhesive
      molecule-1 (VCAM-1), soluble urokinase receptor of plasminogen activator (suPAR),
      thrombin activatable fibrinolysis inhibitor (TAFI), soluble thrombomodulin (TM)
      and plasminogen activator inhibitor-1 (PAI-1) were determined using a canine
      specific ELISA. Concentrations of TM, HMGB-1, VCAM-1 and suPAR were increased in 
      dogs with babesiosis at admission compared to healthy dogs. After treatment,
      concentrations of TM were lower in infected dogs compared to healthy dogs. Dogs
      with babesiosis also had increased concentrations of TM, ICAM-1 and HMGB-1 and
      decreased plasminogen and PAI-1 at presentation compared to day 6 after
      treatment. Dogs with complicated babesiosis had higher concentrations of TM,
      HMGB1 and TAFI at admission compared to the 6th day. CONCLUSIONS: Biomarkers of
      endothelial activation and fibrinolysis were altered in dogs with babesiosis.
      Further studies into their usefulness as biomarkers of disease severity or
      prognosis is warranted.
FAU - Kules, Josipa
AU  - Kules J
AD  - ERA Chair team VetMedZg, Internal Diseases Clinic, Faculty of Veterinary
      Medicine, University of Zagreb, Heinzelova 55, 10 000, Zagreb, Croatia.
FAU - Gotic, Jelena
AU  - Gotic J
AD  - Internal Diseases Clinic, Faculty of Veterinary Medicine, University of Zagreb,
      Heinzelova 55, 10 000, Zagreb, Croatia.
FAU - Mrljak, Vladimir
AU  - Mrljak V
AD  - Internal Diseases Clinic, Faculty of Veterinary Medicine, University of Zagreb,
      Heinzelova 55, 10 000, Zagreb, Croatia. [email protected]
FAU - Baric Rafaj, Renata
AU  - Baric Rafaj R
AD  - Department of Chemistry and Biochemistry, Faculty of Veterinary Medicine,
      University of Zagreb, Heinzelova 55, 10 000, Zagreb, Croatia.
LA  - eng
PT  - Journal Article
DEP - 20170331
PL  - England
TA  - BMC Vet Res
JT  - BMC veterinary research
JID - 101249759
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Babesiosis/*blood/physiopathology
MH  - Biomarkers/blood
MH  - Dog Diseases/*blood/physiopathology
MH  - Dogs
MH  - Endothelium, Vascular/*metabolism
MH  - Female
MH  - *Fibrinolysis
MH  - Male
PMC - PMC5376283
OTO - NOTNLM
OT  - Biomarkers
OT  - Hemostasis
OT  - Vascular Endothelium
EDAT- 2017/04/02 06:00
MHDA- 2017/04/07 06:00
CRDT- 2017/04/02 06:00
PHST- 2016/04/30 [received]
PHST- 2017/03/18 [accepted]
AID - 10.1186/s12917-017-0995-6 [doi]
AID - 10.1186/s12917-017-0995-6 [pii]
PST - epublish
SO  - BMC Vet Res. 2017 Mar 31;13(1):82. doi: 10.1186/s12917-017-0995-6.

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