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Expressions of insulin-like growth factor receptor-1 and cezanne-1 in lung adenocarcinoma.

Abstract IGF1R (insulin-like growth factor receptor-1) was confirmed to play a significant role in the development of cancer. Cezanne-1 overexpression was considered to be associated with enhancement of EGFR signaling pathway and reduced degeneration of EGFR. There was a close relationship between EGFR and IGFR as previous study showed. Dynamic balance between receptor ubiquitination and deubiquitination was critical in the process of termination of IGF signaling pathway. So we conducted an IHC staining to initially prove the correlation. Cezanne-1 and IGF1R expressions were evaluated in 103 patients with lung adenocarcinoma using immunohistochemical (IHC) analysis. The relationship between expressions of cezanne-1 and IGF1R were analyzed by χ2 test. Kaplan-Meier method was used to generate the survival curve, and the statistical difference was calculated by log-rank test. We also used data in R2 system to verify the relationship between IGF1R and cezanne-1. R2 system showed there was a close correlation between IGF1R and cezanne-1. Positive expression of cezanne-1 was detected in 64.1% patients. A significant association was shown between cezanne-1 and IGF1R expression (p < 0.001). Multivariate analysis confirmed that both cezanne-1 and IGF1R expressions were independent prognostic factors for OS. (HR 2.96, 95% CI 1.090-8.060, p = 0.033; HR 2.273, 95% CI 1.016-5.085, p = 0.046, respectively). Our findings indicated both cezanne-1 and IGF1R expressions were negative independent predictive factors for the prognosis of lung adenocarcinoma, respectively. There was a close positive interrelationship between cezanne-1 and IGF1R expression.
PMID
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Authors

Mayor MeshTerms
Keywords

Cezanne-1

Insulin-like growth factor receptor-1

Lung adenocarcinoma

Prognosis

Journal Title medical oncology (northwood, london, england)
Publication Year Start




PMID- 28365890
OWN - NLM
STAT- MEDLINE
DA  - 20170402
DCOM- 20170419
LR  - 20170419
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 34
IP  - 5
DP  - 2017 May
TI  - Expressions of insulin-like growth factor receptor-1 and cezanne-1 in lung
      adenocarcinoma.
PG  - 78
LID - 10.1007/s12032-017-0934-1 [doi]
AB  - IGF1R (insulin-like growth factor receptor-1) was confirmed to play a significant
      role in the development of cancer. Cezanne-1 overexpression was considered to be 
      associated with enhancement of EGFR signaling pathway and reduced degeneration of
      EGFR. There was a close relationship between EGFR and IGFR as previous study
      showed. Dynamic balance between receptor ubiquitination and deubiquitination was 
      critical in the process of termination of IGF signaling pathway. So we conducted 
      an IHC staining to initially prove the correlation. Cezanne-1 and IGF1R
      expressions were evaluated in 103 patients with lung adenocarcinoma using
      immunohistochemical (IHC) analysis. The relationship between expressions of
      cezanne-1 and IGF1R were analyzed by chi2 test. Kaplan-Meier method was used to
      generate the survival curve, and the statistical difference was calculated by
      log-rank test. We also used data in R2 system to verify the relationship between 
      IGF1R and cezanne-1. R2 system showed there was a close correlation between IGF1R
      and cezanne-1. Positive expression of cezanne-1 was detected in 64.1% patients. A
      significant association was shown between cezanne-1 and IGF1R expression (p &lt;
      0.001). Multivariate analysis confirmed that both cezanne-1 and IGF1R expressions
      were independent prognostic factors for OS. (HR 2.96, 95% CI 1.090-8.060, p =
      0.033; HR 2.273, 95% CI 1.016-5.085, p = 0.046, respectively). Our findings
      indicated both cezanne-1 and IGF1R expressions were negative independent
      predictive factors for the prognosis of lung adenocarcinoma, respectively. There 
      was a close positive interrelationship between cezanne-1 and IGF1R expression.
FAU - Pang, Zhaofei
AU  - Pang Z
AD  - Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong
      University, Shandong University, Jinan, 250021, China.
FAU - Cui, Lixuan
AU  - Cui L
AD  - Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong
      University, Shandong University, Jinan, 250021, China.
FAU - Ding, Nan
AU  - Ding N
AD  - Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong
      University, Shandong University, Jinan, 250021, China.
FAU - Zhu, Linhai
AU  - Zhu L
AD  - Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to
      Shandong University, Shandong University, Jinan, 250021, China.
FAU - Qu, Xiao
AU  - Qu X
AD  - Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong
      University, Shandong University, Jinan, 250021, China.
FAU - Dong, Wei
AU  - Dong W
AD  - Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to
      Shandong University, Shandong University, Jinan, 250021, China.
FAU - Du, Jiajun
AU  - Du J
AD  - Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong
      University, Shandong University, Jinan, 250021, China. [email protected]
AD  - Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to
      Shandong University, Shandong University, Jinan, 250021, China.
      [email protected]
FAU - Liu, Qi
AU  - Liu Q
AD  - Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong
      University, Shandong University, Jinan, 250021, China. [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170401
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
RN  - 0 (IGF1R protein, human)
RN  - 0 (Receptors, Somatomedin)
RN  - EC 3.4.- (Endopeptidases)
RN  - EC 3.4.- (OTUD7B protein, human)
RN  - Adenocarcinoma of lung
SB  - IM
MH  - Adenocarcinoma/*metabolism/pathology
MH  - Adult
MH  - Aged
MH  - Endopeptidases/*biosynthesis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Lung Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Receptors, Somatomedin/*biosynthesis
OTO - NOTNLM
OT  - Cezanne-1
OT  - Insulin-like growth factor receptor-1
OT  - Lung adenocarcinoma
OT  - Prognosis
EDAT- 2017/04/04 06:00
MHDA- 2017/04/20 06:00
CRDT- 2017/04/03 06:00
PHST- 2016/10/15 [received]
PHST- 2017/03/28 [accepted]
AID - 10.1007/s12032-017-0934-1 [doi]
AID - 10.1007/s12032-017-0934-1 [pii]
PST - ppublish
SO  - Med Oncol. 2017 May;34(5):78. doi: 10.1007/s12032-017-0934-1. Epub 2017 Apr 1.

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