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Single nucleotide polymorphisms of interleukins associated with hepatitis C virus infection in Egypt.

Abstract Hepatitis C is a liver disease caused by the hepatitis C virus (HCV). It can cause both acute and chronic hepatitis infection. Based on secretion of required cytokines upon infection, HCV can improve its own RNA and successfully complete the replication cycle. Importantly, single nucleotide polymorphisms (SNPs) are the most common type of genetic variation and have been found to play a critical role in modulation of cellular cytokine production and interaction.
PMID
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Authors

Mayor MeshTerms

Polymorphism, Single Nucleotide

Keywords
Journal Title journal of infection in developing countries
Publication Year Start




PMID- 28368861
OWN - NLM
STAT- MEDLINE
DA  - 20170403
DCOM- 20170417
LR  - 20170417
IS  - 1972-2680 (Electronic)
IS  - 1972-2680 (Linking)
VI  - 11
IP  - 3
DP  - 2017 Mar 31
TI  - Single nucleotide polymorphisms of interleukins associated with hepatitis C virus
      infection in Egypt.
PG  - 261-268
LID - 10.3855/jidc.8127 [doi]
AB  - INTRODUCTION: Hepatitis C is a liver disease caused by the hepatitis C virus
      (HCV). It can cause both acute and chronic hepatitis infection. Based on
      secretion of required cytokines upon infection, HCV can improve its own RNA and
      successfully complete the replication cycle. Importantly, single nucleotide
      polymorphisms (SNPs) are the most common type of genetic variation and have been 
      found to play a critical role in modulation of cellular cytokine production and
      interaction. METHODOLOGY: A total of 100 blood samples were obtained from HCV
      patients, and 120 samples were obtained from healthy individuals who served as
      controls. SNPs of interleukin-10/592 (IL-10/592) and IL-4/589 were investigated
      for possible connection with HCV infection. Relative expression of IL-4, IL-6,
      and IL-10 were detected using real-time polymerase chain reaction and
      enzyme-linked immunosorbent assay. RESULTS: The polymorphisms of IL-10 revealed a
      high rate of mutant genotype CC within the location IL-10/592 in HCV patients and
      controls, which resulted in low secretion of IL-10. Interestingly, the findings
      here demonstrate a positive association between HCV load of viremia and the
      mutant genotype IL-4-589/TT accompanied with low expression IL-4 in comparison
      with IL-6 expression. CONCLUSIONS: These data suggest that the expression of IL-4
      is inversely proportional to HCV load of viremia, and this connection is due to
      the high level of mutant genotype IL-4-589/TT in infected patients located in
      gene promoter and inhibits gene expression.
FAU - Khalil, Hany
AU  - Khalil H
AD  - Genetic Engineering and Biotechnology Research Institute, University of Sadat
      City, Sadat City, Egypt. [email protected]
FAU - Arfa, Mohamed
AU  - Arfa M
FAU - El-Masrey, Samir
AU  - El-Masrey S
FAU - El-Sherbini, Sherif M
AU  - El-Sherbini SM
FAU - Abd-Elaziz, Amal A
AU  - Abd-Elaziz AA
LA  - eng
PT  - Journal Article
DEP - 20170331
PL  - Italy
TA  - J Infect Dev Ctries
JT  - Journal of infection in developing countries
JID - 101305410
RN  - 0 (IL10 protein, human)
RN  - 0 (IL4 protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 130068-27-8 (Interleukin-10)
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - Egypt
MH  - Hepacivirus/isolation & purification
MH  - Hepatitis C/*genetics
MH  - Humans
MH  - Interleukin-10/genetics
MH  - Interleukin-4/*genetics
MH  - Interleukin-6/genetics
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Viral Load
EDAT- 2017/04/04 06:00
MHDA- 2017/04/18 06:00
CRDT- 2017/04/04 06:00
PHST- 2016/01/17 [received]
PHST- 2016/09/05 [accepted]
PST - epublish
SO  - J Infect Dev Ctries. 2017 Mar 31;11(3):261-268. doi: 10.3855/jidc.8127.

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