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Aqueous extract of Peperomia pellucida (L.) HBK accelerates fracture healing in Wistar rats.

Abstract Peperomia pellucida (L.) HBK is consumed as vegetable and used in Cameroonian traditional medicine for the management of diseases and for fracture healing. Therefore the aim of this study was to evaluate the effects of the aqueous whole plant extract of Peperomia pellucida on fracture healing in female Wistar rats.
PMID
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Authors

Mayor MeshTerms
Keywords

Alkaline phosphate

Drill-hole

Fracture healing

Haematological parameters

Peperomia pellucida

Journal Title bmc complementary and alternative medicine
Publication Year Start




PMID- 28372562
OWN - NLM
STAT- MEDLINE
DA  - 20170404
DCOM- 20170417
LR  - 20170417
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Apr 04
TI  - Aqueous extract of Peperomia pellucida (L.) HBK accelerates fracture healing in
      Wistar rats.
PG  - 188
LID - 10.1186/s12906-017-1686-3 [doi]
AB  - BACKGROUND: Peperomia pellucida (L.) HBK is consumed as vegetable and used in
      Cameroonian traditional medicine for the management of diseases and for fracture 
      healing. Therefore the aim of this study was to evaluate the effects of the
      aqueous whole plant extract of Peperomia pellucida on fracture healing in female 
      Wistar rats. METHODS: A drill hole injury was created by inserting a drill bit
      inthe diaphysis of the femur. The aqueous extract of the whole plant of Peperomia
      pellucida was administered orally at the doses of 100, 200 and 400 mg/kg to adult
      female Wistar rats. The vehicle (distilled water) was given to the control.
      Besides these rats, one group of rats without fracture received the extract (400 
      mg/kg). After 14 days of treatment, the rats were sacrificed under anesthesia and
      the effects of the extract were evaluated on body weight, the relative weights of
      organs (femurs, uteri and ovaries) and on hematology. Bone (calcium, phosphorus, 
      alkaline phosphatase) and serum biochemical parameters (calcium, phosphorus,
      alkaline phosphatase) were also evaluated. Radiological and histological tests
      were carried out on the femurs. The mineral content of the plant extract was also
      investigated. RESULTS: The extract induced an increase in body weight at high
      dose and in WBCs count at low doses. Aqueous extract from Peperomia pellucida
      increased bone calcium at lowest dose but maintained this parameter at normal
      range at high dose in fractured rat. Alkaline phophatase and phosphorus
      concentrations reduced significantly (p < 0.01) at the dose of 400 mg/kg as
      compared to fractured rats. Moreover, radiological tests revealed a dose
      dependent formation of callus at the level of the fracture gap, confirmed by the 
      formation of a highly dense and compact fibrocartilagenous callus. The mineral
      content of the plant extract revealed the presence of calcium, phosphorus,
      magnesium, sodium and potassium. CONCLUSION: The aqueous extract of P. pellucida 
      accelerates bone healing due partly to the mineral content of the extract. These 
      results confirm its traditional use in the treatment of bone fractures.
FAU - Florence, Ngueguim Tsofack
AU  - Florence NT
AD  - Department of Animal Biology and Physiology, Faculty of Science, University of
      Yaounde1, P.O. Box 812, Yaounde, Cameroon. [email protected]
FAU - Huguette, Sakouong Talle Suewellyne
AU  - Huguette ST
AD  - Department of Animal Biology and Physiology, Faculty of Science, University of
      Yaounde1, P.O. Box 812, Yaounde, Cameroon.
FAU - Hubert, Donfack Jean
AU  - Hubert DJ
AD  - Department of Biomedical Sciences, Faculty of Science, University of Dschang,
      P.O. Box 67, Dschang, Cameroon.
FAU - Raceline, Gounoue Kamkumo
AU  - Raceline GK
AD  - Department of Animal Biology and Physiology, Faculty of Science, University of
      Yaounde1, P.O. Box 812, Yaounde, Cameroon.
FAU - Desire, Dzeufiet Djomeni Paul
AU  - Desire DD
AD  - Department of Animal Biology and Physiology, Faculty of Science, University of
      Yaounde1, P.O. Box 812, Yaounde, Cameroon.
FAU - Pierre, Kamtchouing
AU  - Pierre K
AD  - Department of Animal Biology and Physiology, Faculty of Science, University of
      Yaounde1, P.O. Box 812, Yaounde, Cameroon.
FAU - Theophile, Dimo
AU  - Theophile D
AD  - Department of Animal Biology and Physiology, Faculty of Science, University of
      Yaounde1, P.O. Box 812, Yaounde, Cameroon.
LA  - eng
PT  - Journal Article
DEP - 20170404
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Female
MH  - Femoral Fractures/*drug therapy/physiopathology
MH  - Femur/drug effects/injuries
MH  - Fracture Healing/*drug effects
MH  - Humans
MH  - Peperomia/*chemistry
MH  - Plant Extracts/*administration & dosage/chemistry
MH  - Rats
MH  - Rats, Wistar
PMC - PMC5379737
OTO - NOTNLM
OT  - Alkaline phosphate
OT  - Drill-hole
OT  - Fracture healing
OT  - Haematological parameters
OT  - Peperomia pellucida
EDAT- 2017/04/05 06:00
MHDA- 2017/04/18 06:00
CRDT- 2017/04/05 06:00
PHST- 2016/12/06 [received]
PHST- 2017/03/15 [accepted]
AID - 10.1186/s12906-017-1686-3 [doi]
AID - 10.1186/s12906-017-1686-3 [pii]
PST - epublish
SO  - BMC Complement Altern Med. 2017 Apr 4;17(1):188. doi: 10.1186/s12906-017-1686-3.

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