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Pancreas transplantation.

Abstract The treatment of patients with diabetes mellitus (DM) presents many challenges to care providers and represents a major proportion of healthcare expenditure worldwide. Successful pancreas transplantation provides durable glycemic control and improves survival for patients with diabetes. Progress in the field has mainly been based on large single center studies and the cumulative analyses of registry data from the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry. This review focuses on the outcomes of pancreas transplantation for patients with and without end stage renal disease. It describes the current state of pancreas transplantation, gaps in knowledge, and future studies needed to enable more patients to benefit from this treatment. A common theme that emerges is the need for multicenter randomized trials in pancreas transplantation to define clearly the efficacy, risks, and long term benefits.
PMID
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Authors

Mayor MeshTerms

Pancreas Transplantation

Keywords
Journal Title bmj (clinical research ed.)
Publication Year Start




PMID- 28373161
OWN - NLM
STAT- MEDLINE
DA  - 20170404
DCOM- 20170410
LR  - 20170410
IS  - 1756-1833 (Electronic)
IS  - 0959-535X (Linking)
VI  - 357
DP  - 2017 Apr 03
TI  - Pancreas transplantation.
PG  - j1321
LID - 10.1136/bmj.j1321 [doi]
AB  - The treatment of patients with diabetes mellitus (DM) presents many challenges to
      care providers and represents a major proportion of healthcare expenditure
      worldwide. Successful pancreas transplantation provides durable glycemic control 
      and improves survival for patients with diabetes. Progress in the field has
      mainly been based on large single center studies and the cumulative analyses of
      registry data from the United Network for Organ Sharing (UNOS) and the
      International Pancreas Transplant Registry. This review focuses on the outcomes
      of pancreas transplantation for patients with and without end stage renal
      disease. It describes the current state of pancreas transplantation, gaps in
      knowledge, and future studies needed to enable more patients to benefit from this
      treatment. A common theme that emerges is the need for multicenter randomized
      trials in pancreas transplantation to define clearly the efficacy, risks, and
      long term benefits.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not
      already granted under a licence) please go to
      http://group.bmj.com/group/rights-licensing/permissions.
FAU - Dean, Patrick G
AU  - Dean PG
AD  - Division of Transplantation Surgery, Mayo Clinic and Foundation, 200 First Street
      SW, Rochester, Minnesota 55902, USA [email protected]
AD  - William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo
      Clinic and Foundation.
FAU - Kukla, Aleksandra
AU  - Kukla A
AD  - Division of Nephrology and Hypertension, Mayo Clinic and Foundation.
AD  - William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo
      Clinic and Foundation.
FAU - Stegall, Mark D
AU  - Stegall MD
AD  - Division of Transplantation Surgery, Mayo Clinic and Foundation, 200 First Street
      SW, Rochester, Minnesota 55902, USA.
AD  - William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo
      Clinic and Foundation.
FAU - Kudva, Yogish C
AU  - Kudva YC
AD  - Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic and
      Foundation.
AD  - William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo
      Clinic and Foundation.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170403
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - AIM
SB  - IM
MH  - Diabetes Mellitus, Type 1/epidemiology/*surgery
MH  - Diabetic Nephropathies/surgery
MH  - Humans
MH  - Kidney Transplantation/statistics & numerical data
MH  - *Pancreas Transplantation/adverse effects/statistics & numerical data/trends
MH  - Pancreas, Artificial
MH  - Randomized Controlled Trials as Topic
MH  - Treatment Outcome
EDAT- 2017/04/05 06:00
MHDA- 2017/04/11 06:00
CRDT- 2017/04/05 06:00
PST - epublish
SO  - BMJ. 2017 Apr 3;357:j1321. doi: 10.1136/bmj.j1321.

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