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Effect of Whole-abdominal Irradiation on Penetration Depth of Doxorubicin in Normal Tissue After Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in a Post-mortem Swine Model.

Abstract This study was performed to evaluate the impact of whole-abdominal irradiation on local penetration of doxorubicin into the peritoneum and the abdominal organs in a post-mortem swine model.
PMID
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Authors

Mayor MeshTerms

Disease Models, Animal

Whole-Body Irradiation

Keywords

PIPAC

Post-mortem swine model

intraperitoneal chemotherapy

peritoneal carcinomatosis

whole-abdominal radiation

Journal Title anticancer research
Publication Year Start




PMID- 28373428
OWN - NLM
STAT- MEDLINE
DA  - 20170404
DCOM- 20170413
LR  - 20170413
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 4
DP  - 2017 Apr
TI  - Effect of Whole-abdominal Irradiation on Penetration Depth of Doxorubicin in
      Normal Tissue After Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in a
      Post-mortem Swine Model.
PG  - 1677-1680
AB  - BACKGROUND: This study was performed to evaluate the impact of whole-abdominal
      irradiation on local penetration of doxorubicin into the peritoneum and the
      abdominal organs in a post-mortem swine model. MATERIALS AND METHODS: Doxorubicin
      was aerosolized into the abdominal cavity of swine at a pressure of 12 mmHg CO2
      at room temperature (25 degrees ). One swine was subjected to pressurized
      intraperitoneal aerosol chemotherapy (PIPAC) using Micropump(c) without
      irradiation; the second one received 2 Gy and the third one 7 Gy whole-abdominal 
      irradiation, 15 min prior to PIPAC application. Samples of the peritoneal surface
      were extracted at different positions from within the abdominal cavity. In-tissue
      doxorubicin penetration was measured using fluorescence microscopy on frozen thin
      sections. RESULTS: The depth of penetration of doxorubicin was found to be
      wide-ranging, between 17 mum on the surface of the stomach and 348 mum in the
      small intestine. The penetration depth into the small intestine was 348 mum, 312 
      mum and 265 mum for PIPAC alone, PIPAC with 2 Gy irradiation and PIPAC with 7 Gy 
      irradiation, respectively (p<0.05). The penetration into the liver was 64 mum, 55
      mum and 40 mum, respectively (p=0.05). CONCLUSION: Irradiation was not found to
      increase the depth of doxorubicin penetration into normal tissue in the
      post-mortem swine model. A reduction of doxorubicin penetration was observed
      after application of higher irradiation doses. Further studies are warranted to
      determine if irradiation can be used safely as chemopotentiating agent for
      patients with peritoneal metastases treated with PIPAC.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Khosrawipour, Veria
AU  - Khosrawipour V
AD  - Department of Neuroanatomy, Ruhr University, Bochum, Germany.
FAU - Khosrawipour, Tanja
AU  - Khosrawipour T
AD  - Department of General Surgery, Marien Hospital Herne, Ruhr University, Bochum,
      Germany.
FAU - Hedayat-Pour, Yousef
AU  - Hedayat-Pour Y
AD  - Department of Radiation Oncology, Marien Hospital Herne, Ruhr University, Bochum,
      Germany.
FAU - Diaz-Carballo, David
AU  - Diaz-Carballo D
AD  - Department of Hematology & Medical Oncology, Marien Hospital Herne, Ruhr
      University, Bochum, Germany.
FAU - Bellendorf, Alexander
AU  - Bellendorf A
AD  - Department of Nuclear Medicine, University Clinic Essen, Essen, Germany.
FAU - Bose-Ribeiro, Hugo
AU  - Bose-Ribeiro H
AD  - Department of Radiation Oncology, Marien Hospital Herne, Ruhr University, Bochum,
      Germany.
FAU - Mucke, Ralph
AU  - Mucke R
AD  - Department of Radiation Oncology, Marien Hospital Herne, Ruhr University, Bochum,
      Germany.
FAU - Mohanaraja, Nirushika
AU  - Mohanaraja N
AD  - Department of Neuroanatomy, Ruhr University, Bochum, Germany.
FAU - Adamietz, Irenaus Anton
AU  - Adamietz IA
AD  - Department of Radiation Oncology, Marien Hospital Herne, Ruhr University, Bochum,
      Germany.
FAU - Fakhrian, Khashayar
AU  - Fakhrian K
AD  - Department of Radiation Oncology, Marien Hospital Herne, Ruhr University, Bochum,
      Germany [email protected]
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Aerosols)
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Administration, Inhalation
MH  - Aerosols
MH  - Animals
MH  - Antibiotics, Antineoplastic/administration & dosage/pharmacokinetics
MH  - *Disease Models, Animal
MH  - Doxorubicin/*administration & dosage/*pharmacokinetics
MH  - Male
MH  - Peritoneum/*drug effects/pathology/radiation effects
MH  - Postmortem Changes
MH  - Pressure
MH  - Radiation Dosage
MH  - Swine
MH  - Tissue Distribution
MH  - *Whole-Body Irradiation
OTO - NOTNLM
OT  - *PIPAC
OT  - *Post-mortem swine model
OT  - *intraperitoneal chemotherapy
OT  - *peritoneal carcinomatosis
OT  - *whole-abdominal radiation
EDAT- 2017/04/05 06:00
MHDA- 2017/04/14 06:00
CRDT- 2017/04/05 06:00
PHST- 2017/02/05 [received]
PHST- 2017/03/19 [revised]
PHST- 2017/03/20 [accepted]
AID - 37/4/1677 [pii]
AID - 10.21873/anticanres.11498 [doi]
PST - ppublish
SO  - Anticancer Res. 2017 Apr;37(4):1677-1680.

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