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Ninjurin1 Is Up-regulated in Circulating Prostate Tumor Cells and Plays a Critical Role in Prostate Cancer Cell Motility.

Abstract Ninjurin1 is a 17-kDa membrane protein that is highly expressed in circulating tumor cells (CTCs) obtained from locally-advanced prostate cancer patients. As CTCs are implicated in the initiation of distant metastasis, we examined the potential contribution of Ninjurin1 to the motility of prostate cancer cells.
PMID
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Authors

Mayor MeshTerms

Cell Movement

Keywords

Ninjurin1

Prostate cancer

circulating tumor cell

invasion

migration

Journal Title anticancer research
Publication Year Start




PMID- 28373430
OWN - NLM
STAT- MEDLINE
DA  - 20170404
DCOM- 20170413
LR  - 20170413
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 4
DP  - 2017 Apr
TI  - Ninjurin1 Is Up-regulated in Circulating Prostate Tumor Cells and Plays a
      Critical Role in Prostate Cancer Cell Motility.
PG  - 1687-1696
AB  - BACKGROUND/AIM: Ninjurin1 is a 17-kDa membrane protein that is highly expressed
      in circulating tumor cells (CTCs) obtained from locally-advanced prostate cancer 
      patients. As CTCs are implicated in the initiation of distant metastasis, we
      examined the potential contribution of Ninjurin1 to the motility of prostate
      cancer cells. MATERIALS AND METHODS: Ninjurin1 expression was evaluated in CTCs
      harvested from seven locally advanced patients with no metastatic hallmarks using
      real-time polymerase chain reaction (PCR). The role of Ninjurin1 in cell motility
      was investigated using small interfering RNA (siRNA), neutralizing antibodies
      against Ninjurin1 and Ninjurin1-overexpressing adenoviruses. RESULTS: Ninjurin1
      was ranked as the most significantly up-regulated adhesion protein identified by 
      RNA-Seq analysis. Both Ninjurin1 down-regulation by siRNA and neutralizing
      antibodies blocking Ninjurin1 homophilic interactions effectively inhibited cell 
      motility. In contrast, cell motility was enhanced in prostate cancer cells
      infected with adenovirus enabling Ninjurin1 overexpression. CONCLUSION:
      Ninjurin1-neutralizing antibodies or Ninjurin1-targeting siRNA merit further
      development for patients with metastatic potential.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Park, Juri
AU  - Park J
AD  - Genitourinary Cancer Branch, Research Institute of National Cancer Center,
      Goyang, Republic of Korea.
FAU - Joung, Jae-Young
AU  - Joung JY
AD  - Genitourinary Cancer Branch, Research Institute of National Cancer Center,
      Goyang, Republic of Korea.
FAU - Hwang, Ji-Eun
AU  - Hwang JE
AD  - Genitourinary Cancer Branch, Research Institute of National Cancer Center,
      Goyang, Republic of Korea.
FAU - Hong, Dongwan
AU  - Hong D
AD  - Cancer Immunology Branch, Research Institute of National Cancer Center, Goyang,
      Republic of Korea.
FAU - Park, Weon Seo
AU  - Park WS
AD  - Hematologic Malignancy Branch, Research Institute of National Cancer Center,
      Goyang, Republic of Korea.
FAU - Lee, Sang-Jin
AU  - Lee SJ
AD  - Genitourinary Cancer Branch, Research Institute of National Cancer Center,
      Goyang, Republic of Korea [email protected] [email protected]
FAU - Lee, Kang Hyun
AU  - Lee KH
AD  - Genitourinary Cancer Branch, Research Institute of National Cancer Center,
      Goyang, Republic of Korea [email protected] [email protected]
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 0 (NINJ1 protein, human)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Small Interfering)
SB  - IM
MH  - Apoptosis
MH  - Blotting, Western
MH  - Cell Adhesion Molecules, Neuronal/antagonists & inhibitors/genetics/*metabolism
MH  - *Cell Movement
MH  - Cell Proliferation
MH  - High-Throughput Nucleotide Sequencing
MH  - Humans
MH  - Male
MH  - Neoplastic Cells, Circulating/metabolism/*pathology
MH  - Nerve Growth Factors/antagonists & inhibitors/genetics/*metabolism
MH  - Prostatic Neoplasms/genetics/metabolism/*pathology
MH  - RNA, Messenger/genetics
MH  - RNA, Small Interfering/genetics
MH  - Real-Time Polymerase Chain Reaction
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tumor Cells, Cultured
MH  - Up-Regulation
OTO - NOTNLM
OT  - *Ninjurin1
OT  - *Prostate cancer
OT  - *circulating tumor cell
OT  - *invasion
OT  - *migration
EDAT- 2017/04/05 06:00
MHDA- 2017/04/14 06:00
CRDT- 2017/04/05 06:00
PHST- 2017/02/07 [received]
PHST- 2017/03/07 [revised]
PHST- 2017/03/08 [accepted]
AID - 37/4/1687 [pii]
AID - 10.21873/anticanres.11500 [doi]
PST - ppublish
SO  - Anticancer Res. 2017 Apr;37(4):1687-1696.

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