PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.




PMID- 28373433
OWN - NLM
STAT- MEDLINE
DA  - 20170404
DCOM- 20170413
LR  - 20170413
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 4
DP  - 2017 Apr
TI  - Bisphenol A Inhibits Cell Proliferation and Reduces the Motile Potential of
      Murine LM8 Osteosarcoma Cells.
PG  - 1711-1722
AB  - AIM: The aim of this study was to examine the effect of bisphenol A (BPA) on the 
      proliferation and motility potential of murine LM8 osteosarcoma cells. MATERIALS 
      AND METHODS: LM8 cells were treated for 3 days with or without 80 muM BPA. The
      effect of BPA on cell proliferation was determined by DNA measurement in the
      cultures and 5-bromo-2'-deoxyuridine (BrdU) incorporation study. Ethanol-fixed
      cells were stained with hematoxylin-eosin (H&E) to visualize cell morphology.
      Cell motility was assayed using inserts with uncoated membranes in invasion
      chambers. Expression of cell division cycle 42 (CDC42) was determined by
      immunofluorescence staining and western blotting. RESULTS: BPA reduced the DNA
      content of cultures and the number of BrdU-positive cells. BPA induced a change
      in morphology from cuboidal with multiple filopodia on the cell surface to
      spindle-shaped with a smooth cell surface. BPA-treated cells expressed less CDC42
      and were less motile than untreated cells. CONCLUSION: BPA inhibited DNA
      replication and cell proliferation. BPA inhibited filopodia formation and motile 
      potential by inhibiting CDC42 expression in LM8 cells.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Kidani, Teruki
AU  - Kidani T
AD  - Department of Bone and Joint Surgery, Ehime University Graduate School of
      Medicine, Toon, Japan [email protected]
FAU - Yasuda, Rie
AU  - Yasuda R
AD  - Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural
      University of Health Sciences, Tobe, Japan.
FAU - Miyawaki, Joji
AU  - Miyawaki J
AD  - Department of Bone and Joint Surgery, Ehime University Graduate School of
      Medicine, Toon, Japan.
FAU - Oshima, Yusuke
AU  - Oshima Y
AD  - Department of Molecular Medicine for Pathogenesis, Ehime University Graduate
      School of Medicine, Toon, Japan.
FAU - Miura, Hiromasa
AU  - Miura H
AD  - Department of Bone and Joint Surgery, Ehime University Graduate School of
      Medicine, Toon, Japan.
FAU - Masuno, Hiroshi
AU  - Masuno H
AD  - Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural
      University of Health Sciences, Tobe, Japan.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Estrogens, Non-Steroidal)
RN  - 0 (Phenols)
RN  - 0 (RNA, Messenger)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Benzhydryl Compounds/*pharmacology
MH  - Blotting, Western
MH  - Bone Neoplasms/drug therapy/metabolism/*pathology
MH  - Cell Movement/*drug effects
MH  - Cell Proliferation/*drug effects
MH  - Estrogens, Non-Steroidal/*pharmacology
MH  - Fluorescent Antibody Technique
MH  - Gene Expression Regulation, Neoplastic/*drug effects
MH  - Mice
MH  - Osteosarcoma/drug therapy/metabolism/*pathology
MH  - Phenols/*pharmacology
MH  - RNA, Messenger/genetics
MH  - Real-Time Polymerase Chain Reaction
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tumor Cells, Cultured
OTO - NOTNLM
OT  - *CDC42 expression
OT  - *Murine LM8 osteosarcoma cells
OT  - *bisphenol A
OT  - *cell motility
OT  - *cell proliferation
OT  - *filopodia formation
EDAT- 2017/04/05 06:00
MHDA- 2017/04/14 06:00
CRDT- 2017/04/05 06:00
PHST- 2017/02/15 [received]
PHST- 2017/03/10 [revised]
PHST- 2017/03/13 [accepted]
AID - 37/4/1711 [pii]
AID - 10.21873/anticanres.11503 [doi]
PST - ppublish
SO  - Anticancer Res. 2017 Apr;37(4):1711-1722.

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