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Photodynamic Therapy Mediated by a Novel Chlorin Derivative, TONS 501-Na, in EMT6 cells.

Abstract The lipophilic photosensitizer, TONS 501, is a novel porphyrin-derived methyl ester that was developed for photodynamic antimicrobial chemotherapy. This study developed a hydrophilic and anionic porphyrin salt of this compound (TONS 501-Na) for use in photodynamic therapy (PDT). This chlorin derivative is synthesized from the protoporphyrin IX dimethyl ester.
PMID
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Authors

Mayor MeshTerms

Light

Photochemotherapy

Keywords

Apoptosis

TONS 501-Na

photodynamic therapy

Journal Title anticancer research
Publication Year Start




PMID- 28373434
OWN - NLM
STAT- MEDLINE
DA  - 20170404
DCOM- 20170413
LR  - 20170413
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 4
DP  - 2017 Apr
TI  - Photodynamic Therapy Mediated by a Novel Chlorin Derivative, TONS 501-Na, in EMT6
      cells.
PG  - 1723-1728
AB  - BACKGROUND: The lipophilic photosensitizer, TONS 501, is a novel
      porphyrin-derived methyl ester that was developed for photodynamic antimicrobial 
      chemotherapy. This study developed a hydrophilic and anionic porphyrin salt of
      this compound (TONS 501-Na) for use in photodynamic therapy (PDT). This chlorin
      derivative is synthesized from the protoporphyrin IX dimethyl ester. MATERIALS
      AND METHODS: We investigated the in vitro cytotoxic effects of TONS
      501-Na-mediated PDT on EMT6 mouse breast cancer cells. EMT6 cells were incubated 
      with 0-100 mug/ml TONS 501-Na for 24 h prior to replacing the culture medium and 
      exposing the cells to 6 mW/cm2 diode laser irradiation at 0-13 J/cm2 to induce
      PDT. Morphological changes and cell viability were evaluated 24 h after PDT. The 
      percentages of apoptotic cells were evaluated 4 h and 24 h after PDT. RESULTS:
      The concentrations of TONS 501-Na that killed 50% of EMT6 cells after exposure to
      light doses of 0, 0.4, 3, 6, or 13 J/cm2 were 84.6, 33.2, 18, 8.2, and 2.2
      mug/ml, respectively. Tumor cells exposed to PDT showed chromatin condensation
      and fragmentation. The percentages of apoptotic cells increased in a TONS 501-Na 
      concentration-dependent manner in the PDT group, and were significantly higher
      than those in the control group or in cells treated with TONS 501-Na or laser
      irradiation alone. CONCLUSION: TONS 501-Na-mediated PDT induced mouse breast
      cancer cell death in a concentration-dependent manner. Future studies should
      evaluate the in vivo pharmacokinetics, tissue distribution, and photodynamic
      effects of TONS 501-Na.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Osaki, Tomohiro
AU  - Osaki T
AD  - Department of Veterinary Clinical Medicine, School of Veterinary Medicine,
      Tottori University, Tottori, Japan [email protected]
FAU - Sakata, Isao
AU  - Sakata I
AD  - Porphyrin Laboratory, Okayama, Japan.
FAU - Uto, Yoshihiro
AU  - Uto Y
AD  - Faculty of Bioscience and Bioindustry, Tokushima University, Tokushima, Japan.
FAU - Azuma, Kazuo
AU  - Azuma K
AD  - Department of Veterinary Clinical Medicine, School of Veterinary Medicine,
      Tottori University, Tottori, Japan.
FAU - Murahata, Yusuke
AU  - Murahata Y
AD  - Department of Veterinary Clinical Medicine, School of Veterinary Medicine,
      Tottori University, Tottori, Japan.
FAU - Tsuka, Takeshi
AU  - Tsuka T
AD  - Department of Veterinary Clinical Medicine, School of Veterinary Medicine,
      Tottori University, Tottori, Japan.
FAU - Itoh, Norihiko
AU  - Itoh N
AD  - Department of Veterinary Clinical Medicine, School of Veterinary Medicine,
      Tottori University, Tottori, Japan.
FAU - Imagawa, Tomohiro
AU  - Imagawa T
AD  - Department of Veterinary Clinical Medicine, School of Veterinary Medicine,
      Tottori University, Tottori, Japan.
FAU - Okamoto, Yoshiharu
AU  - Okamoto Y
AD  - Department of Veterinary Clinical Medicine, School of Veterinary Medicine,
      Tottori University, Tottori, Japan.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0
      (13,17-bis(1-carboxypropionyl)carbamoylethyl-3-ethenyl-2-hydroxy-3-hydroxyiminoet
      hlidene-2,7,12,18-tetramethylporphyrin)
RN  - 0 (Photosensitizing Agents)
RN  - 0 (Porphyrins)
RN  - 2683-84-3 (chlorin)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects/radiation effects
MH  - Female
MH  - *Light
MH  - Mammary Neoplasms, Animal/*drug therapy/pathology/radiotherapy
MH  - Mice
MH  - *Photochemotherapy
MH  - Photosensitizing Agents/*pharmacology
MH  - Porphyrins/*chemistry/*pharmacology
MH  - Tumor Cells, Cultured
OTO - NOTNLM
OT  - *Apoptosis
OT  - *TONS 501-Na
OT  - *photodynamic therapy
EDAT- 2017/04/05 06:00
MHDA- 2017/04/14 06:00
CRDT- 2017/04/05 06:00
PHST- 2017/02/17 [received]
PHST- 2017/03/13 [revised]
PHST- 2017/03/14 [accepted]
AID - 37/4/1723 [pii]
AID - 10.21873/anticanres.11504 [doi]
PST - ppublish
SO  - Anticancer Res. 2017 Apr;37(4):1723-1728.

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