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PMID- 28373447
DA  - 20170404
DCOM- 20170413
LR  - 20170413
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 4
DP  - 2017 Apr
TI  - Neurovascular Bundle Infiltration Can Explain Local Relapses Using Conformal
      Radiotherapy of Prostate Cancer.
PG  - 1825-1830
AB  - AIM: To quantify the impact of decreased margins for two treatment techniques,
      three-dimensional conformal radiotherapy (3D-CRT) and volumetric-modulated arc
      therapy (VMAT), on local control in curative treatment of prostate cancer.
      MATERIALS AND METHODS: The planning target volume (PTV) margins were decreased in
      steps of 1 mm from 10 to 1 mm. Treatment plans using 3D-CRT and VMAT technique
      were produced for all margin sizes and the dose to the neuro vascular bundles
      (NVB), that was not included in the PTV, was investigated. RESULTS: Due to the
      more conformal dose delivery using VMAT, the dose to the NVB decreased more
      rapidly by VMAT compared to the 3D-CRT plans. The dose difference was significant
      for margins from 1-7 mm. CONCLUSION: One should be very cautious before clinical 
      routines are changed, bearing in mind whether the change means more conformal
      treatment technique, smaller margins or target segmentation in different imaging 
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Johansson, Andreas K
AU  - Johansson AK
AD  - Section of Medical Physics, Department of Immunology, Genetics and Pathology,
      Uppsala University, Uppsala, Sweden [email protected]
AD  - Centre for Clinical Research Sormland, Uppsala University, Eskilstuna, Sweden.
FAU - Lennernas, Bo
AU  - Lennernas B
AD  - Department of Oncology, Orebro University Hospital, Orebro, Sweden.
FAU - Isacsson, Ulf
AU  - Isacsson U
AD  - Section of Medical Physics, Department of Immunology, Genetics and Pathology,
      Uppsala University, Uppsala, Sweden.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Adenocarcinoma/pathology/*radiotherapy
MH  - Humans
MH  - Male
MH  - Neoplasm Grading
MH  - Neoplasm Recurrence, Local/*diagnosis/etiology
MH  - Neovascularization, Pathologic/*etiology
MH  - Prognosis
MH  - Prostatic Neoplasms/pathology/*radiotherapy
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Conformal/*adverse effects
MH  - Radiotherapy, Intensity-Modulated/*adverse effects
OT  - *3D-CRT
OT  - *Prostate cancer
OT  - *local relapse
OT  - *radiotherapy
EDAT- 2017/04/05 06:00
MHDA- 2017/04/14 06:00
CRDT- 2017/04/05 06:00
PHST- 2017/02/17 [received]
PHST- 2017/03/10 [revised]
PHST- 2017/03/13 [accepted]
AID - 37/4/1825 [pii]
AID - 10.21873/anticanres.11517 [doi]
PST - ppublish
SO  - Anticancer Res. 2017 Apr;37(4):1825-1830.

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