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Breast Tumor Resembling Tall Cell Variant of Papillary Thyroid Carcinoma: A Solid Papillary Neoplasm With Characteristic Immunohistochemical Profile and Few Recurrent Mutations.

Abstract Breast tumor resembling tall cell variant of papillary thyroid carcinoma (BTRPTC) is a rare breast lesion that is unrelated to thyroid carcinoma. Morphologically, it shows a solid papillary lesion with bland cytology, eosinophilic/amphophilic secretions, nuclear grooves, reversal of nuclear polarity (recently described), and nuclear inclusions. Clinical course is often uneventful with few exceptions reported in the literature. Herein, we report three additional cases.
PMID
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Breast tumor resembling the tall cell variant of papillary thyroid carcinoma: a case report.

Authors

Mayor MeshTerms

Mutation

Keywords

ATM

Breast tumor resembling tall cell variant of papillary thyroid carcinoma

CK5

ER

IDH2

Myoepithelial markers

PIK3CA mutations

Reverse nuclear polarity

Solid papillary neoplasm

Journal Title american journal of clinical pathology
Publication Year Start




PMID- 28375433
OWN - NLM
STAT- MEDLINE
DA  - 20170404
DCOM- 20170411
LR  - 20170411
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 147
IP  - 4
DP  - 2017 Apr 01
TI  - Breast Tumor Resembling Tall Cell Variant of Papillary Thyroid Carcinoma: A Solid
      Papillary Neoplasm With Characteristic Immunohistochemical Profile and Few
      Recurrent Mutations.
PG  - 399-410
LID - 10.1093/ajcp/aqx016 [doi]
AB  - Objectives: Breast tumor resembling tall cell variant of papillary thyroid
      carcinoma (BTRPTC) is a rare breast lesion that is unrelated to thyroid
      carcinoma. Morphologically, it shows a solid papillary lesion with bland
      cytology, eosinophilic/amphophilic secretions, nuclear grooves, reversal of
      nuclear polarity (recently described), and nuclear inclusions. Clinical course is
      often uneventful with few exceptions reported in the literature. Herein, we
      report three additional cases. Methods: Immunohistochemical staining and
      next-generation sequencing was performed on all three cases. Results: The
      lesional cells on all cases were positive for cytokeratin 5 and S100, with weak
      expression/lack of estrogen receptor. No staining was observed for myoepithelial 
      markers (p63 and myosin heavy chain) around the lesion. IDH2 mutations were
      identified in two cases at nucleotide 172 (cases 1 and 3). ATM gene mutation was 
      identified in cases 2 and 3 and PIK3CA mutation in case 3. All patients are
      currently without disease. Conclusions: BTRPTC is a slow-growing neoplastic
      lesion that needs to be distinguished from other papillary lesions for optimizing
      therapy.
FAU - Bhargava, Rohit
AU  - Bhargava R
AD  - From the Magee-Womens Hospital of University of Pittsburgh Medical Center,
      Pittsburgh, PA.
FAU - Florea, Anca V
AU  - Florea AV
AD  - McGill University, Montreal, Canada.
FAU - Pelmus, Manuela
AU  - Pelmus M
AD  - McGill University, Montreal, Canada.
FAU - Jones, Miroslawa W
AU  - Jones MW
AD  - From the Magee-Womens Hospital of University of Pittsburgh Medical Center,
      Pittsburgh, PA.
FAU - Bonaventura, Marguerite
AU  - Bonaventura M
AD  - From the Magee-Womens Hospital of University of Pittsburgh Medical Center,
      Pittsburgh, PA.
FAU - Wald, Abigail
AU  - Wald A
AD  - University of Pittsburgh Medical Center-Presbyterian, Pittsburgh, PA.
FAU - Nikiforova, Marina
AU  - Nikiforova M
AD  - University of Pittsburgh Medical Center-Presbyterian, Pittsburgh, PA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (CKAP4 protein, human)
RN  - 0 (Keratin-5)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Estrogen)
RN  - EC 3.6.4.1 (Myosin Heavy Chains)
RN  - Thyroid cancer, papillary
SB  - AIM
SB  - IM
MH  - Aged
MH  - Breast Neoplasms/chemistry/genetics/*pathology
MH  - Carcinoma/*pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Keratin-5/analysis
MH  - Membrane Proteins/analysis
MH  - Middle Aged
MH  - *Mutation
MH  - Myosin Heavy Chains/analysis
MH  - Receptors, Estrogen/analysis
MH  - Thyroid Neoplasms/*pathology
OTO - NOTNLM
OT  - *ATM
OT  - *Breast tumor resembling tall cell variant of papillary thyroid carcinoma
OT  - *CK5
OT  - *ER
OT  - *IDH2
OT  - *Myoepithelial markers
OT  - *PIK3CA mutations
OT  - *Reverse nuclear polarity
OT  - *Solid papillary neoplasm
EDAT- 2017/04/05 06:00
MHDA- 2017/04/12 06:00
CRDT- 2017/04/05 06:00
AID - 3075294 [pii]
AID - 10.1093/ajcp/aqx016 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2017 Apr 1;147(4):399-410. doi: 10.1093/ajcp/aqx016.

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