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Identification of factors that impact recurrence in patients with borderline ovarian tumors.

Abstract The lack of consensus around best practices for management of borderline ovarian tumors (BOT) is, in part, to the lack of available data and of clarity in interpreting relationships among various factors that impact outcomes. The objective of this study was to identify clinicopathological factors that impact prognosis of patients with borderline ovarian tumors (BOT) and to address features of this disease with the objective of providing clarity in decision making around management of BOT.
PMID
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Authors

Mayor MeshTerms
Keywords

Borderline ovarian tumor

Fertility-preserving surgery

Lymphadenectomy

Recurrence

Survival

Journal Title journal of ovarian research
Publication Year Start




PMID- 28376898
OWN - NLM
STAT- MEDLINE
DA  - 20170405
DCOM- 20170418
LR  - 20170418
IS  - 1757-2215 (Electronic)
IS  - 1757-2215 (Linking)
VI  - 10
IP  - 1
DP  - 2017 Apr 04
TI  - Identification of factors that impact recurrence in patients with borderline
      ovarian tumors.
PG  - 23
LID - 10.1186/s13048-017-0316-5 [doi]
AB  - BACKGROUND: The lack of consensus around best practices for management of
      borderline ovarian tumors (BOT) is, in part, to the lack of available data and of
      clarity in interpreting relationships among various factors that impact outcomes.
      The objective of this study was to identify clinicopathological factors that
      impact prognosis of patients with borderline ovarian tumors (BOT) and to address 
      features of this disease with the objective of providing clarity in decision
      making around management of BOT. RESULTS: A total of 178 BOT patients were
      included in this study, with a median age of 43 years and a median follow-up time
      of 37 months. Thirty-two (18.0%) recurrences and 5 (2.8%) deaths were observed in
      this study group. Multivariate analysis showed that fertility-preserving surgery 
      (P = 0.0223 for bilateral cystectomy) and invasive implants (P = 0.0030) were
      significantly associated with worse PFS, whereas lymphadenectomy (P = 0.0129) was
      related to improved PFS. No factors were found to be associated with OS due to
      the limited number of deaths. In addition, patients with serous BOT more commonly
      had abnormal levels of CA125, while patients with mucinous BOT more commonly had 
      abnormal levels of CEA. Patients with abnormal levels of CA125, or CA19-9, or HE4
      had significantly larger tumor sizes. CONCLUSIONS: Our study reveals the impact
      of certain types of fertility-preserving surgery, lymphadenectomy and invasive
      implants on PFS of BOT patients. Blood cancer markers may be associated with
      histology and size of BOT. Our findings may assist in selection of optimum
      treatment for BOT patients.
FAU - Chen, Xi
AU  - Chen X
AD  - Department of Gynecologic Oncology, Zhejiang Cancer Hospital, 1 Banshan East
      Road, Hangzhou, Zhejiang, 310022, China.
FAU - Fang, Chenyan
AU  - Fang C
AD  - Department of Gynecologic Oncology, Zhejiang Cancer Hospital, 1 Banshan East
      Road, Hangzhou, Zhejiang, 310022, China.
FAU - Zhu, Tao
AU  - Zhu T
AD  - Department of Gynecologic Oncology, Zhejiang Cancer Hospital, 1 Banshan East
      Road, Hangzhou, Zhejiang, 310022, China.
FAU - Zhang, Ping
AU  - Zhang P
AD  - Department of Gynecologic Oncology, Zhejiang Cancer Hospital, 1 Banshan East
      Road, Hangzhou, Zhejiang, 310022, China.
FAU - Yu, Aijun
AU  - Yu A
AD  - Department of Gynecologic Oncology, Zhejiang Cancer Hospital, 1 Banshan East
      Road, Hangzhou, Zhejiang, 310022, China. [email protected]
FAU - Wang, Shihua
AU  - Wang S
AD  - Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC, 
      27157, USA.
LA  - eng
PT  - Journal Article
DEP - 20170404
PL  - England
TA  - J Ovarian Res
JT  - Journal of ovarian research
JID - 101474849
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease-Free Survival
MH  - Female
MH  - Fertility Preservation
MH  - Humans
MH  - Lymph Node Excision
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*pathology
MH  - Ovarian Neoplasms/*pathology/therapy
MH  - Survival Analysis
MH  - Young Adult
PMC - PMC5379723
OTO - NOTNLM
OT  - Borderline ovarian tumor
OT  - Fertility-preserving surgery
OT  - Lymphadenectomy
OT  - Recurrence
OT  - Survival
EDAT- 2017/04/06 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/06 06:00
PHST- 2017/02/06 [received]
PHST- 2017/03/21 [accepted]
AID - 10.1186/s13048-017-0316-5 [doi]
AID - 10.1186/s13048-017-0316-5 [pii]
PST - epublish
SO  - J Ovarian Res. 2017 Apr 4;10(1):23. doi: 10.1186/s13048-017-0316-5.

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