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Serum and peritoneal fluid concentrations of soluble human leukocyte antigen, tumor necrosis factor alpha and interleukin 10 in patients with selected ovarian pathologies.

Abstract Although immune system plays a key role in the pathogenesis of both endometriosis and ovarian cancer, its function is different. Therefore, we hypothesized, that selected immune parameters can serve as diagnostic markers of these two conditions. The aim of this study was to compare serum and peritoneal fluid concentrations of sHLA-G, IL-10 and TNF-alpha in women with selected ovarian pathologies: benign serous cysts, endometrioma and malignant tumors. Clinical significance of using them for diagnostic purposes in women with serous ovarian cysts, endometriosis, and ovarian cancer, which in the future may improve the early diagnosis of ovarian diseases.
PMID
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Authors

Mayor MeshTerms
Keywords

Endometriosis

IL-10

Ovarian cancer

Ovarian cysts

TNF-alpha

Tumor escape

sHLA-G

Journal Title journal of ovarian research
Publication Year Start




PMID- 28376925
OWN - NLM
STAT- MEDLINE
DA  - 20170405
DCOM- 20170418
LR  - 20170418
IS  - 1757-2215 (Electronic)
IS  - 1757-2215 (Linking)
VI  - 10
IP  - 1
DP  - 2017 Apr 04
TI  - Serum and peritoneal fluid concentrations of soluble human leukocyte antigen,
      tumor necrosis factor alpha and interleukin 10 in patients with selected ovarian 
      pathologies.
PG  - 25
LID - 10.1186/s13048-017-0320-9 [doi]
AB  - BACKGROUND: Although immune system plays a key role in the pathogenesis of both
      endometriosis and ovarian cancer, its function is different. Therefore, we
      hypothesized, that selected immune parameters can serve as diagnostic markers of 
      these two conditions. The aim of this study was to compare serum and peritoneal
      fluid concentrations of sHLA-G, IL-10 and TNF-alpha in women with selected
      ovarian pathologies: benign serous cysts, endometrioma and malignant tumors.
      Clinical significance of using them for diagnostic purposes in women with serous 
      ovarian cysts, endometriosis, and ovarian cancer, which in the future may improve
      the early diagnosis of ovarian diseases. CASE PRESENTATION: The study included
      women treated surgically for benign serous ovarian cysts, ovarian endometrioma
      and serous ovarian adenocarcinomas. Peripheral blood and peritoneal fluid samples
      were obtained intraoperatively. Patients with benign serous cysts, endometrioma
      and ovarian malignancies did not differ significantly in terms of their serum and
      peritoneal fluid concentrations of sHLA-G. Ovarian cancer patients presented with
      significantly higher median serum concentrations of IL-10 and TNF-alpha than
      other study subjects. Median concentrations of IL-10 and TNF-alpha in peritoneal 
      fluid turned out to be the highest in ovarian cancer patients, followed by women 
      with endometrioma and subjects with benign serous cysts. All these intergroup
      differences were statistically significant. Irrespective of the group, median
      concentrations of sHLA-G, IL-10 and TNF-alpha in peritoneal fluid were higher
      than serum levels of these markers. CONCLUSIONS: Elevated serum and peritoneal
      fluid concentrations of IL-10 and TNF-alpha distinguish ovarian malignancies and 
      endometriomas from benign serous ovarian cysts. In contrast to endometriosis,
      ovarian malignancies are characterized by elevated peritoneal fluid
      concentrations of IL-10 and TNF-alpha, elevated serum concentrations of IL-10 and
      low serum levels of TNF-alpha. Serum and peritoneal fluid concentrations of
      sHLA-G have no diagnostic value in differentiating between ovarian malignancies
      and endometriomas.
FAU - Sipak-Szmigiel, Olimpia
AU  - Sipak-Szmigiel O
AD  - Department of Obstetrical and Gynecological Nursing, Pomeranian Medical
      University, 48 Zolnierska, 71-210, Szczecin, Poland. [email protected]
FAU - Wlodarski, Piotr
AU  - Wlodarski P
AD  - Clinical Hospital SPS ZOZ "Zdroje", Maczna 4, 70-780, Szczecin, Poland.
FAU - Ronin-Walknowska, Elzbieta
AU  - Ronin-Walknowska E
AD  - Clinic of Maternofetal Medicine and Gynecology, Pomeranian Medical University in 
      Szczecin, Unii Lubelskiej 1, 71-242, Szczecin, Poland.
FAU - Niedzielski, Andrzej
AU  - Niedzielski A
AD  - Clinical Hospital SPS ZOZ "Zdroje", Maczna 4, 70-780, Szczecin, Poland.
FAU - Karakiewicz, Beata
AU  - Karakiewicz B
AD  - Public Health Department, Pomeranian Medical University in Szczecin, Zolnierska
      48, 71-210, Szczecin, Poland.
FAU - Sluczanowska-Glabowska, Sylwia
AU  - Sluczanowska-Glabowska S
AD  - Deparment of Physiology, Pomeranian Medical University in Szczecin, al.
      Powstancow Wlkp. 72, 70-111, Szczecin, Poland.
FAU - Laszczynska, Maria
AU  - Laszczynska M
AD  - Department of Histology and Developmental Biology, Pomeranian Medical University 
      in Szczecin, Zolnierska 48, 71-210, Szczecin, Poland.
FAU - Malinowski, Witold
AU  - Malinowski W
AD  - Department of Obstetrical and Gynecological Nursing, Pomeranian Medical
      University, 48 Zolnierska, 71-210, Szczecin, Poland.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170404
PL  - England
TA  - J Ovarian Res
JT  - Journal of ovarian research
JID - 101474849
RN  - 0 (Biomarkers)
RN  - 0 (IL10 protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Ascitic Fluid/*cytology/metabolism
MH  - Biomarkers/blood
MH  - Endometriosis/blood
MH  - Female
MH  - Humans
MH  - Interleukin-10/*blood
MH  - Middle Aged
MH  - Ovarian Cysts/blood
MH  - Ovarian Diseases/*blood
MH  - Ovarian Neoplasms/blood
MH  - Tumor Necrosis Factor-alpha/*blood
PMC - PMC5381140
OTO - NOTNLM
OT  - *Endometriosis
OT  - *IL-10
OT  - *Ovarian cancer
OT  - *Ovarian cysts
OT  - *TNF-alpha
OT  - *Tumor escape
OT  - *sHLA-G
EDAT- 2017/04/06 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/06 06:00
PHST- 2016/11/21 [received]
PHST- 2017/03/22 [accepted]
AID - 10.1186/s13048-017-0320-9 [doi]
AID - 10.1186/s13048-017-0320-9 [pii]
PST - epublish
SO  - J Ovarian Res. 2017 Apr 4;10(1):25. doi: 10.1186/s13048-017-0320-9.

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