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Brominated flame retardant: environmental and exposed individuals' health impact.

Abstract Since Antiquity, men have used chemicals to protect their goods against fire. Effective and easy to use, brominated flame retardants are used since decades massively in plastic industry. Such like other organohalogenated compounds, brominated flame retardants are very persistent in the environment and able to accumulate along the food chain. Many authors highlight their presence in the environment, in many animal species and in the human serum. Worryingly, man is exposed as soon as the pregnancy and then by the breastfeeding. This exposition may have consequence on our health. Many studies (in vitro, in vivo or epidemiologic) highlight brominated flame retardant negative effects on the endocrine system, mainly on the thyroid function but also on the reproduction, the neurodevelopment in the children and on the metabolism with increasing diabetes risk. If authorities and some big enterprises are aware about the problematic, new studies are needed to confirm previous results, elucidate endocrine disrupting mechanisms and highlight hypothetical synergies with other pollutants such like PCBs.
PMID
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Authors

Mayor MeshTerms
Keywords

brominated flame retardants

contamination

endocrine disruptors

persistency

thyroid function

Journal Title annales de biologie clinique
Publication Year Start




PMID- 28377327
OWN - NLM
STAT- In-Process
DA  - 20170405
LR  - 20170405
IS  - 1950-6112 (Electronic)
IS  - 0003-3898 (Linking)
VI  - 75
IP  - 2
DP  - 2017 Apr 01
TI  - Brominated flame retardant: environmental and exposed individuals' health impact.
PG  - 146-157
LID - 10.1684/abc.2017.1221 [doi]
AB  - Since Antiquity, men have used chemicals to protect their goods against fire.
      Effective and easy to use, brominated flame retardants are used since decades
      massively in plastic industry. Such like other organohalogenated compounds,
      brominated flame retardants are very persistent in the environment and able to
      accumulate along the food chain. Many authors highlight their presence in the
      environment, in many animal species and in the human serum. Worryingly, man is
      exposed as soon as the pregnancy and then by the breastfeeding. This exposition
      may have consequence on our health. Many studies (in vitro, in vivo or
      epidemiologic) highlight brominated flame retardant negative effects on the
      endocrine system, mainly on the thyroid function but also on the reproduction,
      the neurodevelopment in the children and on the metabolism with increasing
      diabetes risk. If authorities and some big enterprises are aware about the
      problematic, new studies are needed to confirm previous results, elucidate
      endocrine disrupting mechanisms and highlight hypothetical synergies with other
      pollutants such like PCBs.
FAU - Dufour, Patrice
AU  - Dufour P
AD  - Service de toxicologie clinique, medico-legale, de l'environnement et en
      entreprise, Domaine universitaire du Sart Tilman, CHU B35, Liege, Belgique.
FAU - Charlier, Corinne
AU  - Charlier C
AD  - Service de toxicologie clinique, medico-legale, de l'environnement et en
      entreprise, Domaine universitaire du Sart Tilman, CHU B35, Liege, Belgique.
LA  - eng
PT  - Journal Article
TT  - Les retardateurs de flamme bromes : impact sur l'environnement et la sante des
      individus exposes.
PL  - France
TA  - Ann Biol Clin (Paris)
JT  - Annales de biologie clinique
JID - 2984690R
OTO - NOTNLM
OT  - brominated flame retardants
OT  - contamination
OT  - endocrine disruptors
OT  - persistency
OT  - thyroid function
EDAT- 2017/04/06 06:00
MHDA- 2017/04/06 06:00
CRDT- 2017/04/06 06:00
AID - abc.2017.1221 [pii]
AID - 10.1684/abc.2017.1221 [doi]
PST - ppublish
SO  - Ann Biol Clin (Paris). 2017 Apr 1;75(2):146-157. doi: 10.1684/abc.2017.1221.

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