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Integrated approach of nutritional and molecular epidemiology, mineralogical and chemical pollutant characterisation: the protocol of a cross-sectional study in women.

Abstract Environmentally-related health and disease are the result of the exposome, the totality of a person's environmental exposures, from all sources and routes, across their lifespan. Epigenetic phenomena, including DNA methylation, can be potentially modified by environmental and lifestyle factors, and result in environmental reprogramming of the genome for exposed individuals and for future generations of offspring.
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Authors

Mayor MeshTerms

Public Health

Keywords

EPIDEMIOLOGY

NUTRITION & DIETETICS

PUBLIC HEALTH

Journal Title bmj open
Publication Year Start




PMID- 28377395
OWN - NLM
STAT- MEDLINE
DCOM- 20180126
LR  - 20180201
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 7
IP  - 4
DP  - 2017 Apr 4
TI  - Integrated approach of nutritional and molecular epidemiology, mineralogical and 
      chemical pollutant characterisation: the protocol of a cross-sectional study in
      women.
PG  - e014756
LID - 10.1136/bmjopen-2016-014756 [doi]
AB  - INTRODUCTION: Environmentally-related health and disease are the result of the
      exposome, the totality of a person's environmental exposures, from all sources
      and routes, across their lifespan. Epigenetic phenomena, including DNA
      methylation, can be potentially modified by environmental and lifestyle factors, 
      and result in environmental reprogramming of the genome for exposed individuals
      and for future generations of offspring. OBJECTIVE: The objective of the project 
      is to evaluate the risk of DNA hypomethylation due to air pollution,
      Mediterranean diet adherence, folate intake, and demographic and socioeconomic
      factors, in healthy women living in the metropolitan area of Catania, Italy.
      METHODS AND ANALYSIS: Non-pregnant healthy women will be enrolled in a
      cross-sectional study. Sociodemographic, lifestyle and dietary intake information
      will be collected. LINE-1 methylation will be measured by pyrosequencing. The
      participants' home addresses will be geocoded and each woman will be assigned to 
      the closest monitoring station for particulate matter (PM) exposure assessment.
      Mineralogical-chemical characterisation of PM and cellular model assays will be
      performed. An integrated approach will be designed to estimate the combined
      possible effect of air pollution, Mediterranean diet adherence, folate intake and
      other lifestyle characteristics on LINE-1 methylation levels. ETHICS AND
      DISSEMINATION: The project has been approved by the ethics committees of the
      involved institution and funded by the University of Catania (Finanziamento della
      Ricerca, FIR 2014). All participants will be fully informed of the purpose and
      procedures of the study, and signed written consents will be obtained. All the
      data collected will be treated confidentially and analysed in an aggregate and
      anonymous way. The results will be published in peer-reviewed journals and
      communicated to local public health agencies, in order to provide essential
      information for timely and effective public health action.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not
      already granted under a licence) please go to
      http://www.bmj.com/company/products-services/rights-and-licensing/.
FAU - Barchitta, Martina
AU  - Barchitta M
AD  - Department of Medical and Surgical Sciences and Advanced Technologies "GF
      Ingrassia", University of Catania, Catania, Italy.
AD  - LaPoSS, Laboratory of Policies and Social Services, University of Catania,
      Catania, Italy.
FAU - Quattrocchi, Annalisa
AU  - Quattrocchi A
AD  - Department of Medical and Surgical Sciences and Advanced Technologies "GF
      Ingrassia", University of Catania, Catania, Italy.
FAU - Maugeri, Andrea
AU  - Maugeri A
AD  - Department of Medical and Surgical Sciences and Advanced Technologies "GF
      Ingrassia", University of Catania, Catania, Italy.
FAU - Barone, Germana
AU  - Barone G
AD  - Department of Biological, Geological and Environmental Sciences, University of
      Catania, Catania, Italy.
FAU - Mazzoleni, Paolo
AU  - Mazzoleni P
AD  - Department of Biological, Geological and Environmental Sciences, University of
      Catania, Catania, Italy.
FAU - Catalfo, Alfio
AU  - Catalfo A
AD  - Department of Chemical Science, Section of Photochemistry and Photobiology,
      University of Catania, Catania, Italy.
FAU - De Guidi, Guido
AU  - De Guidi G
AD  - Department of Chemical Science, Section of Photochemistry and Photobiology,
      University of Catania, Catania, Italy.
AD  - Research Centre for the analysis, the monitoring and methodology for
      environmental risk assessment (CRAM3RA), University of Catania, Catania, Italy.
FAU - Iemmolo, Maria
AU  - Iemmolo M
AD  - Department of Clinical and Experimental Medicine, University of Catania, Catania,
      Italy.
FAU - Crimi, Nunzio
AU  - Crimi N
AD  - Department of Clinical and Experimental Medicine, University of Catania, Catania,
      Italy.
FAU - Agodi, Antonella
AU  - Agodi A
AD  - Department of Medical and Surgical Sciences and Advanced Technologies "GF
      Ingrassia", University of Catania, Catania, Italy.
AD  - LaPoSS, Laboratory of Policies and Social Services, University of Catania,
      Catania, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170404
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Air Pollutants/adverse effects/*analysis
MH  - Air Pollution/adverse effects/*analysis
MH  - Cross-Sectional Studies
MH  - Environmental Exposure/adverse effects
MH  - Environmental Health
MH  - Environmental Illness/*epidemiology
MH  - Environmental Monitoring/*methods
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Incidence
MH  - Italy/epidemiology
MH  - Middle Aged
MH  - Molecular Epidemiology/*methods
MH  - Particulate Matter/*analysis
MH  - *Public Health
MH  - Socioeconomic Factors
MH  - Young Adult
PMC - PMC5387935
OTO - NOTNLM
OT  - *EPIDEMIOLOGY
OT  - *NUTRITION & DIETETICS
OT  - *PUBLIC HEALTH
EDAT- 2017/04/06 06:00
MHDA- 2018/01/27 06:00
CRDT- 2017/04/06 06:00
PHST- 2017/04/06 06:00 [entrez]
PHST- 2017/04/06 06:00 [pubmed]
PHST- 2018/01/27 06:00 [medline]
AID - bmjopen-2016-014756 [pii]
AID - 10.1136/bmjopen-2016-014756 [doi]
PST - epublish
SO  - BMJ Open. 2017 Apr 4;7(4):e014756. doi: 10.1136/bmjopen-2016-014756.