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Downregulation of PRDM1 promotes cellular invasion and lung cancer metastasis.

Abstract The zinc-finger transcription factor PRDM1 (PR domain containing 1) plays key roles in the development of malignant lymphoma, leukaemia and some non-haematopoietic cancers, including breast cancer, colorectal cancer and glioma. However, little is known regarding the function of PRDM1 in the progression of lung cancer. Here, we found that PRDM1 is expressed in normal human lung epithelium but is downregulated in lung cancer cells. Decreased expression of PRDM1 correlates with poor prognosis in lung cancer. Depletion of PRDM1 in lung cancer cells promotes cellular invasion and anoikis resistance in vitro and lung metastasis in vivo. PRDM1 is silenced by an ectopically expressed lymphocyte-specific transcription factor Aiolos. The transcription of these two genes is negatively correlated in 206 lung epithelial cell lines. Our results indicate that PRDM1 functions as a tumour suppressor in lung cancer.
PMID
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Authors

Mayor MeshTerms
Keywords

PRDM1

gene silencing

lung cancer

metastasis

transcriptional regulation

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28378641
OWN - NLM
STAT- MEDLINE
DA  - 20170405
DCOM- 20170410
LR  - 20170410
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 4
DP  - 2017 Apr
TI  - Downregulation of PRDM1 promotes cellular invasion and lung cancer metastasis.
PG  - 1010428317695929
LID - 10.1177/1010428317695929 [doi]
AB  - The zinc-finger transcription factor PRDM1 (PR domain containing 1) plays key
      roles in the development of malignant lymphoma, leukaemia and some
      non-haematopoietic cancers, including breast cancer, colorectal cancer and
      glioma. However, little is known regarding the function of PRDM1 in the
      progression of lung cancer. Here, we found that PRDM1 is expressed in normal
      human lung epithelium but is downregulated in lung cancer cells. Decreased
      expression of PRDM1 correlates with poor prognosis in lung cancer. Depletion of
      PRDM1 in lung cancer cells promotes cellular invasion and anoikis resistance in
      vitro and lung metastasis in vivo. PRDM1 is silenced by an ectopically expressed 
      lymphocyte-specific transcription factor Aiolos. The transcription of these two
      genes is negatively correlated in 206 lung epithelial cell lines. Our results
      indicate that PRDM1 functions as a tumour suppressor in lung cancer.
FAU - Zhu, Zhiyan
AU  - Zhu Z
AD  - 1 Department of Immunology, Tianjin Medical University, Tianjin, China.
AD  - 2 Tianjin Research Center of Basic Medical Science, Tianjin Medical University,
      Tianjin, China.
FAU - Wang, Hao
AU  - Wang H
AD  - 1 Department of Immunology, Tianjin Medical University, Tianjin, China.
FAU - Wei, Yiliang
AU  - Wei Y
AD  - 1 Department of Immunology, Tianjin Medical University, Tianjin, China.
FAU - Meng, Fanrong
AU  - Meng F
AD  - 1 Department of Immunology, Tianjin Medical University, Tianjin, China.
FAU - Liu, Zhe
AU  - Liu Z
AD  - 1 Department of Immunology, Tianjin Medical University, Tianjin, China.
FAU - Zhang, Zhenfa
AU  - Zhang Z
AD  - 3 Department of Lung Cancer, Lung Cancer Center, Tianjin Medical University
      Cancer Institute and Hospital, Tianjin, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (Fibronectins)
RN  - 0 (IKZF3 protein, human)
RN  - 0 (Repressor Proteins)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 138415-26-6 (PRDM1 protein, human)
RN  - 148971-36-2 (Ikaros Transcription Factor)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Animals
MH  - Anoikis
MH  - Caspases/metabolism
MH  - Cell Line, Tumor
MH  - Cell Movement
MH  - Cells, Cultured
MH  - Down-Regulation
MH  - Female
MH  - Fibronectins/metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Ikaros Transcription Factor/metabolism
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/genetics/metabolism/mortality/*pathology
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - Neoplasm Invasiveness
MH  - Neoplasm Metastasis
MH  - Prognosis
MH  - Repressor Proteins/*metabolism
MH  - Tumor Suppressor Proteins/*metabolism
OTO - NOTNLM
OT  - PRDM1
OT  - gene silencing
OT  - lung cancer
OT  - metastasis
OT  - transcriptional regulation
EDAT- 2017/04/06 06:00
MHDA- 2017/04/11 06:00
CRDT- 2017/04/06 06:00
AID - 10.1177/1010428317695929 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Apr;39(4):1010428317695929. doi: 10.1177/1010428317695929.

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