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Effect of combined administration of aripiprazole and fluoxetine on cognitive functions in female rats exposed to ethyl alcohol.

Abstract Alcoholism is a chronic and recurrent disease. The studies on ethyl alcohol show a progressive deterioration of cognitive functions (motor hyperactivity, operating memory). The aim of the study was to establish whether combined single and chronic administration of aripiprazole (ARI) and fluoxetine (FLU) affects animal locomotor activity or modifies spatial memory functions in female rats exposed to ethyl alcohol. Female Wistar rats were studied in the Morris Water Maze (MWM) and locomotor activity test. Rats undergoing the MWM and locomotor activity test were injected with saline on day 1, 7, 14 and 21 of testing. Results showed a statistically significant mobility increase in the group of ethanol‑exposed females (CEt) (21 days) compared to the non-ethanol-exposed group (CNEt). Upon ARI administration to CEt, no statistically significant differences in animal mobility were found, either upon single or chronic administration. Chronic administration of FLU (21 days) as well as combined administration of ARI+FLU (14 and 21 days) caused a statistically significant reduction of the females' mobility compared to the control CEt group. Single and chronic administration of ARI (7x) both show a spatial memory improvement in CEt. No memory improvement was observed, however, after 14 and 21 days of ARI administration. FLU, likewise, improved spatial memory both upon single and chronic administration. Combined administration of ARI+FLU improved memory in CEt only upon single administration. Lack of effect upon chronic administration may be due to tolerance to memory improvement developing upon combined administration of ARI+FLU. It can be concluded that ARI (1.5 mg/kg), FLU (5 mg/kg), and combined administration of these drugs improves spatial memory in CEt.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title acta neurobiologiae experimentalis
Publication Year Start




PMID- 28379219
OWN - NLM
STAT- MEDLINE
DA  - 20170405
DCOM- 20170414
LR  - 20170414
IS  - 1689-0035 (Electronic)
IS  - 0065-1400 (Linking)
VI  - 77
IP  - 1
DP  - 2017
TI  - Effect of combined administration of aripiprazole and fluoxetine on cognitive
      functions in female rats exposed to ethyl alcohol.
PG  - 86-93
AB  - Alcoholism is a chronic and recurrent disease. The studies on ethyl alcohol show 
      a progressive deterioration of cognitive functions (motor hyperactivity,
      operating memory). The aim of the study was to establish whether combined single 
      and chronic administration of aripiprazole (ARI) and fluoxetine (FLU) affects
      animal locomotor activity or modifies spatial memory functions in female rats
      exposed to ethyl alcohol. Female Wistar rats were studied in the Morris Water
      Maze (MWM) and locomotor activity test. Rats undergoing the MWM and locomotor
      activity test were injected with saline on day 1, 7, 14 and 21 of testing.
      Results showed a statistically significant mobility increase in the group of
      ethanolexposed females (CEt) (21 days) compared to the non-ethanol-exposed group 
      (CNEt). Upon ARI administration to CEt, no statistically significant differences 
      in animal mobility were found, either upon single or chronic administration.
      Chronic administration of FLU (21 days) as well as combined administration of
      ARI+FLU (14 and 21 days) caused a statistically significant reduction of the
      females' mobility compared to the control CEt group. Single and chronic
      administration of ARI (7x) both show a spatial memory improvement in CEt. No
      memory improvement was observed, however, after 14 and 21 days of ARI
      administration. FLU, likewise, improved spatial memory both upon single and
      chronic administration. Combined administration of ARI+FLU improved memory in CEt
      only upon single administration. Lack of effect upon chronic administration may
      be due to tolerance to memory improvement developing upon combined administration
      of ARI+FLU. It can be concluded that ARI (1.5 mg/kg), FLU (5 mg/kg), and combined
      administration of these drugs improves spatial memory in CEt.
FAU - Kus, Krzysztof
AU  - Kus K
AD  - Department of Pharmacoeconomics and Social Pharmacy, Poznan University of Medical
      Sciences, Poznan, Poland, [email protected]
FAU - Ratajczak, Piotr
AU  - Ratajczak P
AD  - Department of Pharmacoeconomics and Social Pharmacy, Poznan University of Medical
      Sciences, Poznan, Poland.
FAU - Czaja, Natasza
AU  - Czaja N
AD  - Department of Pharmacoeconomics and Social Pharmacy, Poznan University of Medical
      Sciences, Poznan, Poland.
FAU - Zaprutko, Tomasz
AU  - Zaprutko T
AD  - Department of Pharmacoeconomics and Social Pharmacy, Poznan University of Medical
      Sciences, Poznan, Poland.
FAU - Nowakowska, Elzbieta
AU  - Nowakowska E
AD  - Department of Pharmacoeconomics and Social Pharmacy, Poznan University of Medical
      Sciences, Poznan, Poland.
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Acta Neurobiol Exp (Wars)
JT  - Acta neurobiologiae experimentalis
JID - 1246675
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Central Nervous System Depressants)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 3K9958V90M (Ethanol)
RN  - 82VFR53I78 (Aripiprazole)
SB  - IM
MH  - Animals
MH  - Antipsychotic Agents/*therapeutic use
MH  - Aripiprazole/*therapeutic use
MH  - Avoidance Learning/drug effects
MH  - Central Nervous System Depressants/toxicity
MH  - Cognition Disorders/*drug therapy/*etiology
MH  - Disease Models, Animal
MH  - Drug Therapy, Combination
MH  - Ethanol/toxicity
MH  - Female
MH  - Fluoxetine/*therapeutic use
MH  - Locomotion/drug effects
MH  - Maze Learning/drug effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/*physiopathology
MH  - Rats
MH  - Rats, Wistar
MH  - Reaction Time/drug effects
MH  - Time Factors
EDAT- 2017/04/06 06:00
MHDA- 2017/04/15 06:00
CRDT- 2017/04/06 06:00
AID - 7708 [pii]
PST - ppublish
SO  - Acta Neurobiol Exp (Wars). 2017;77(1):86-93.

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