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Long-term consumption of fermented rooibos herbal tea offers neuroprotection against ischemic brain injury in rats.

Abstract Stroke is the second leading cause of death worldwide, affecting about 240 people a day in South Africa and leaving survivors with residual disabilities. At the moment, there is no clinically approved neuroprotective product for stroke but the consumption of plant polyphenols has been suggested to offer some protection against stroke. In this study, we investigated the effects of long-term consumption of fermented rooibos herbal tea (FRHT) on ischemia/reperfusion (I/R)-induced brain injury in adult male Wistar rats. FRHT was administered to the animals ad libitum for 7 weeks prior to the induction of ischemic injury via a 20-minute bilateral occlusion of the common carotid arteries (BCCAO) followed by reperfusion for 24, 96 and 168 hours respectively. Neurobehavioural deficits, brain oedema, blood-brain barrier (BBB) damage, apoptosis, lipid peroxidation and total antioxidant capacity were subsequently evaluated using standard methods. Our results showed that long-term consumption of FRHT by Wistar rats signi icantly reduced brain oedema and neuronal apoptosis, but did not attenuate BBB damage following cerebral ischemia. Analysis of whole-brain homogenates showed significantly reduced lipid peroxidation levels, increased total antioxidant capacity and resulted in improved neurobehavioural outcomes in FRHT-treated rats when compared with untreated animals. Taken together, our results tend to suggest that continuous consumption of FRHT could confer some protection against ischemic brain injury (IBI) and is therefore highly recommended for patients with stroke-predisposing conditions.
PMID
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Authors

Mayor MeshTerms

Teas, Herbal

Keywords
Journal Title acta neurobiologiae experimentalis
Publication Year Start




PMID- 28379220
OWN - NLM
STAT- MEDLINE
DA  - 20170405
DCOM- 20170414
LR  - 20170414
IS  - 1689-0035 (Electronic)
IS  - 0065-1400 (Linking)
VI  - 77
IP  - 1
DP  - 2017
TI  - Long-term consumption of fermented rooibos herbal tea offers neuroprotection
      against ischemic brain injury in rats.
PG  - 94-105
AB  - Stroke is the second leading cause of death worldwide, affecting about 240 people
      a day in South Africa and leaving survivors with residual disabilities. At the
      moment, there is no clinically approved neuroprotective product for stroke but
      the consumption of plant polyphenols has been suggested to offer some protection 
      against stroke. In this study, we investigated the effects of long-term
      consumption of fermented rooibos herbal tea (FRHT) on ischemia/reperfusion
      (I/R)-induced brain injury in adult male Wistar rats. FRHT was administered to
      the animals ad libitum for 7 weeks prior to the induction of ischemic injury via 
      a 20-minute bilateral occlusion of the common carotid arteries (BCCAO) followed
      by reperfusion for 24, 96 and 168 hours respectively. Neurobehavioural deficits, 
      brain oedema, blood-brain barrier (BBB) damage, apoptosis, lipid peroxidation and
      total antioxidant capacity were subsequently evaluated using standard methods.
      Our results showed that long-term consumption of FRHT by Wistar rats signi
      icantly reduced brain oedema and neuronal apoptosis, but did not attenuate BBB
      damage following cerebral ischemia. Analysis of whole-brain homogenates showed
      significantly reduced lipid peroxidation levels, increased total antioxidant
      capacity and resulted in improved neurobehavioural outcomes in FRHT-treated rats 
      when compared with untreated animals. Taken together, our results tend to suggest
      that continuous consumption of FRHT could confer some protection against ischemic
      brain injury (IBI) and is therefore highly recommended for patients with
      stroke-predisposing conditions.
FAU - Akinrinmade, Olusiji
AU  - Akinrinmade O
AD  - Department of Medical Biosciences, University of the Western Cape, Bellville,
      South Africa.
FAU - Omoruyi, Sylvester
AU  - Omoruyi S
AD  - Department of Medical Biosciences, University of the Western Cape, Bellville,
      South Africa.
FAU - Dietrich, Daneel
AU  - Dietrich D
AD  - Department of Medical Biosciences, University of the Western Cape, Bellville,
      South Africa.
FAU - Ekpo, Okobi
AU  - Ekpo O
AD  - Department of Medical Biosciences, University of the Western Cape, Bellville,
      South Africa, [email protected]
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Acta Neurobiol Exp (Wars)
JT  - Acta neurobiologiae experimentalis
JID - 1246675
RN  - 0 (Avemar)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Plant Extracts)
RN  - 0 (Teas, Herbal)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Aspalathus/*chemistry
MH  - Blood-Brain Barrier/drug effects/physiopathology
MH  - Brain/drug effects/metabolism
MH  - Brain Edema/drug therapy/etiology
MH  - Brain Injuries/etiology/*prevention & control
MH  - Carotid Artery Diseases/complications
MH  - Disease Models, Animal
MH  - Exploratory Behavior/drug effects
MH  - Fluorescence Recovery After Photobleaching
MH  - In Situ Nick-End Labeling
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Neuroprotective Agents/*therapeutic use
MH  - Oxygen Radical Absorbance Capacity
MH  - Plant Extracts
MH  - Rats
MH  - Rats, Wistar
MH  - *Teas, Herbal
EDAT- 2017/04/06 06:00
MHDA- 2017/04/15 06:00
CRDT- 2017/04/06 06:00
AID - 7709 [pii]
PST - ppublish
SO  - Acta Neurobiol Exp (Wars). 2017;77(1):94-105.

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