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Association of ARID5B gene variants with acute lymphoblastic leukemia in Yemeni children.

Abstract Studies have shown an association between ARID5B gene polymorphisms and childhood acute lymphoblastic leukemia. However, the association between ARID5B variants and acute lymphoblastic leukemia among the Arab population still needs to be studied. The aim of this study was to investigate the association between ARID5B variants with acute lymphoblastic leukemia in Yemeni children. A total of 14 ARID5B gene single nucleotide polymorphisms (SNPs) were genotyped in 289 Yemeni children, of whom 136 had acute lymphoblastic leukemia and 153 were controls, using the nanofluidic Dynamic Array (Fluidigm 192.24 Dynamic Array). Using logistic regression adjusted for age and gender, the risks of acute lymphoblastic leukemia were presented as odds ratios and 95% confidence intervals. We found that nine SNPs were associated with acute lymphoblastic leukemia under additive genetic models: rs7073837, rs10740055, rs7089424, rs10821936, rs4506592, rs10994982, rs7896246, rs10821938, and rs7923074. Furthermore, the recessive models revealed that six SNPs were risk factors for acute lymphoblastic leukemia: rs10740055, rs7089424, rs10994982, rs7896246, rs10821938, and rs7923074. The gender-specific impact of these SNPs under the recessive genetic model revealed that SNPs rs10740055, rs10994982, and rs6479779 in females, and rs10821938 and rs7923074 in males were significantly associated with acute lymphoblastic leukemia risk. Under the dominant model, SNPs rs7073837, rs10821936, rs7896246, and rs6479778 in males only showed striking association with acute lymphoblastic leukemia. The additive model revealed that SNPs with significant association with acute lymphoblastic leukemia were rs10821936 (both males and females); rs7073837, rs10740055, rs10994982, and rs4948487 (females only); and rs7089424, rs7896246, rs10821938, and rs7923074 (males only). In addition, the ARID5B haplotype block (CGAACACAA) showed a higher risk for acute lymphoblastic leukemia. The haplotype (CCCGACTGC) was associated with protection against acute lymphoblastic leukemia. In conclusion, our study has shown that ARID5B variants are associated with acute lymphoblastic leukemia in Yemeni children with several gender biases of ARID5B single nucleotide polymorphisms reported.
PMID
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Authors

Mayor MeshTerms

Polymorphism, Single Nucleotide

Keywords

ARID5B

Childhood leukemia

genotyping

haplotype

single nucleotide polymorphism

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28381164
OWN - NLM
STAT- MEDLINE
DA  - 20170406
DCOM- 20170418
LR  - 20170418
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 4
DP  - 2017 Apr
TI  - Association of ARID5B gene variants with acute lymphoblastic leukemia in Yemeni
      children.
PG  - 1010428317697573
LID - 10.1177/1010428317697573 [doi]
AB  - Studies have shown an association between ARID5B gene polymorphisms and childhood
      acute lymphoblastic leukemia. However, the association between ARID5B variants
      and acute lymphoblastic leukemia among the Arab population still needs to be
      studied. The aim of this study was to investigate the association between ARID5B 
      variants with acute lymphoblastic leukemia in Yemeni children. A total of 14
      ARID5B gene single nucleotide polymorphisms (SNPs) were genotyped in 289 Yemeni
      children, of whom 136 had acute lymphoblastic leukemia and 153 were controls,
      using the nanofluidic Dynamic Array (Fluidigm 192.24 Dynamic Array). Using
      logistic regression adjusted for age and gender, the risks of acute lymphoblastic
      leukemia were presented as odds ratios and 95% confidence intervals. We found
      that nine SNPs were associated with acute lymphoblastic leukemia under additive
      genetic models: rs7073837, rs10740055, rs7089424, rs10821936, rs4506592,
      rs10994982, rs7896246, rs10821938, and rs7923074. Furthermore, the recessive
      models revealed that six SNPs were risk factors for acute lymphoblastic leukemia:
      rs10740055, rs7089424, rs10994982, rs7896246, rs10821938, and rs7923074. The
      gender-specific impact of these SNPs under the recessive genetic model revealed
      that SNPs rs10740055, rs10994982, and rs6479779 in females, and rs10821938 and
      rs7923074 in males were significantly associated with acute lymphoblastic
      leukemia risk. Under the dominant model, SNPs rs7073837, rs10821936, rs7896246,
      and rs6479778 in males only showed striking association with acute lymphoblastic 
      leukemia. The additive model revealed that SNPs with significant association with
      acute lymphoblastic leukemia were rs10821936 (both males and females); rs7073837,
      rs10740055, rs10994982, and rs4948487 (females only); and rs7089424, rs7896246,
      rs10821938, and rs7923074 (males only). In addition, the ARID5B haplotype block
      (CGAACACAA) showed a higher risk for acute lymphoblastic leukemia. The haplotype 
      (CCCGACTGC) was associated with protection against acute lymphoblastic leukemia. 
      In conclusion, our study has shown that ARID5B variants are associated with acute
      lymphoblastic leukemia in Yemeni children with several gender biases of ARID5B
      single nucleotide polymorphisms reported.
FAU - Al-Absi, Boshra
AU  - Al-Absi B
AD  - 1 Department of Molecular Medicine, Faculty of Medicine, University of Malaya,
      Kuala Lumpur, Malaysia.
FAU - Noor, Suzita M
AU  - Noor SM
AD  - 2 Department of Biomedical Science, Faculty of Medicine, University of Malaya,
      Kuala Lumpur, Malaysia.
FAU - Saif-Ali, Riyadh
AU  - Saif-Ali R
AD  - 3 Department of Biochemistry and Molecular Biology, Faculty of Medicine, Sana'a
      University, Sana'a, Yemen.
FAU - Salem, Sameer D
AU  - Salem SD
AD  - 3 Department of Biochemistry and Molecular Biology, Faculty of Medicine, Sana'a
      University, Sana'a, Yemen.
FAU - Ahmed, Radwan H
AU  - Ahmed RH
AD  - 1 Department of Molecular Medicine, Faculty of Medicine, University of Malaya,
      Kuala Lumpur, Malaysia.
FAU - Razif, Muhammad Fm
AU  - Razif MF
AD  - 1 Department of Molecular Medicine, Faculty of Medicine, University of Malaya,
      Kuala Lumpur, Malaysia.
FAU - Muniandy, Sekaran
AU  - Muniandy S
AD  - 1 Department of Molecular Medicine, Faculty of Medicine, University of Malaya,
      Kuala Lumpur, Malaysia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (ARID5B protein, human)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Child
MH  - DNA-Binding Proteins/*genetics
MH  - Female
MH  - Haplotypes
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/etiology/*genetics
MH  - Risk
MH  - Transcription Factors/*genetics
OTO - NOTNLM
OT  - ARID5B
OT  - Childhood leukemia
OT  - genotyping
OT  - haplotype
OT  - single nucleotide polymorphism
EDAT- 2017/04/07 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/07 06:00
AID - 10.1177/1010428317697573 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Apr;39(4):1010428317697573. doi: 10.1177/1010428317697573.

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