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Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma.

Abstract To investigate hypoxia-induced factor-1 alpha expression in distinct oral squamous cell carcinoma subtypes and topographies and correlate with clinicopathological data. Hypoxia-induced factor-1 alpha expression was assessed by immunohistochemistry in 93 cases of OSCC. Clinical and histopathological data were reviewed from medical records. Hypoxia-induced factor-1 alpha status was distinct according to tumor location, subtype and topography affect. In superficial oral squamous cell carcinomas, most tumor cells overexpressed hypoxia-induced factor-1 alpha, whereas hypoxia-induced factor-1 alpha was restricted to the intratumoral region in conventional squamous cell carcinomas. All basaloid squamous cell carcinomas exhibited downregulation of hypoxia-induced factor-1 alpha. Interestingly, metastatic lymph nodes (91.7%, p = 0.001) and the intratumoral regions of corresponding primary tumors (58.3%, p = 0.142) showed hypoxia-induced factor-1 alpha-positive tumor cells. Overall survival was poor in patients with metastatic lymph nodes. Hypoxia-induced factor-1 alpha has distinct expression patterns in different oral squamous cell carcinoma subtypes and topographies, suggesting that low oxygen tension promotes the growth pattern of superficial and conventional squamous cell carcinoma, but not basaloid squamous cell carcinoma. Indeed, a hypoxic environment may facilitate regional metastasis, making it a useful diagnostic and prognostic marker in primary tumors.
PMID
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Authors

Mayor MeshTerms
Keywords

Basaloid squamous cell carcinomas

hypoxia-induced factor-1 alpha

metastasis

oral squamous cell carcinoma

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28381176
OWN - NLM
STAT- MEDLINE
DA  - 20170406
DCOM- 20170418
LR  - 20170418
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 4
DP  - 2017 Apr
TI  - Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic
      oral squamous cell carcinoma.
PG  - 1010428317695527
LID - 10.1177/1010428317695527 [doi]
AB  - To investigate hypoxia-induced factor-1 alpha expression in distinct oral
      squamous cell carcinoma subtypes and topographies and correlate with
      clinicopathological data. Hypoxia-induced factor-1 alpha expression was assessed 
      by immunohistochemistry in 93 cases of OSCC. Clinical and histopathological data 
      were reviewed from medical records. Hypoxia-induced factor-1 alpha status was
      distinct according to tumor location, subtype and topography affect. In
      superficial oral squamous cell carcinomas, most tumor cells overexpressed
      hypoxia-induced factor-1 alpha, whereas hypoxia-induced factor-1 alpha was
      restricted to the intratumoral region in conventional squamous cell carcinomas.
      All basaloid squamous cell carcinomas exhibited downregulation of hypoxia-induced
      factor-1 alpha. Interestingly, metastatic lymph nodes (91.7%, p = 0.001) and the 
      intratumoral regions of corresponding primary tumors (58.3%, p = 0.142) showed
      hypoxia-induced factor-1 alpha-positive tumor cells. Overall survival was poor in
      patients with metastatic lymph nodes. Hypoxia-induced factor-1 alpha has distinct
      expression patterns in different oral squamous cell carcinoma subtypes and
      topographies, suggesting that low oxygen tension promotes the growth pattern of
      superficial and conventional squamous cell carcinoma, but not basaloid squamous
      cell carcinoma. Indeed, a hypoxic environment may facilitate regional metastasis,
      making it a useful diagnostic and prognostic marker in primary tumors.
FAU - Ribeiro, Maisa
AU  - Ribeiro M
AD  - 1 School of Dentistry, Federal University of Goias, Goiania, Brazil.
FAU - Teixeira, Sarah R
AU  - Teixeira SR
AD  - 1 School of Dentistry, Federal University of Goias, Goiania, Brazil.
FAU - Azevedo, Monarko N
AU  - Azevedo MN
AD  - 1 School of Dentistry, Federal University of Goias, Goiania, Brazil.
FAU - Fraga, Ailton C Jr
AU  - Fraga AC Jr
AD  - 2 Anatomic Pathology Sector, Araujo Jorge Hospital, Goiania, Brazil.
FAU - Gontijo, Antonio Pm
AU  - Gontijo AP
AD  - 3 Head and Neck Sector, Araujo Jorge Hospital, Goiania, Brazil.
FAU - Vencio, Eneida F
AU  - Vencio EF
AD  - 1 School of Dentistry, Federal University of Goias, Goiania, Brazil.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/chemistry/mortality/*pathology
MH  - Female
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*analysis
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/chemistry/mortality/*pathology
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
OTO - NOTNLM
OT  - Basaloid squamous cell carcinomas
OT  - hypoxia-induced factor-1 alpha
OT  - metastasis
OT  - oral squamous cell carcinoma
EDAT- 2017/04/07 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/07 06:00
AID - 10.1177/1010428317695527 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Apr;39(4):1010428317695527. doi: 10.1177/1010428317695527.

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