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Expression and associations of TRAF1, BMI-1, ALDH1, and Lin28B in oral squamous cell carcinoma.

Abstract Tumor necrosis factor receptor-associated factor 1, an adaptor protein of tumor necrosis factor 2, is involved in classical nuclear factor (NF)-κB activation and lymphocyte recruitment. However, less is known about the expression and association of tumor necrosis factor receptor-associated factor 1 with cancer stem cell markers in oral squamous cell carcinoma. This study aimed to investigate the expression of tumor necrosis factor receptor-associated factor 1 and stem cell characteristic markers (lin28 homolog B, B cell-specific Moloney murine leukemia virus integration site 1, and aldehyde dehydrogenase 1) in oral squamous cell carcinoma and analyze their relations. Paraffin-embedded tissues of 78 oral squamous cell carcinomas, 39 normal oral mucosa, and 12 oral dysplasia tissues were employed in tissue microarrays, and the expression of tumor necrosis factor receptor-associated factor 1, B cell-specific Moloney murine leukemia virus integration site 1, aldehyde dehydrogenase 1, and lin28 homolog B was measured by immunohistostaining and digital pathological analysis. The expression of tumor necrosis factor receptor-associated factor 1 was higher in the oral squamous cell carcinoma group as compared with the expression in the oral mucosa (p < 0.01) and oral dysplasia (p < 0.001) groups. In addition, the expression of tumor necrosis factor receptor-associated factor 1 was associated with those of B cell-specific Moloney murine leukemia virus integration site 1, aldehyde dehydrogenase 1, and lin28 homolog B (p = 0.032, r(2) = 0.109; p < 0.0001, r(2) = 0.64; and p < 0.001, r(2) = 0.16) in oral squamous cell carcinoma. The patient survival rate was lower in the highly expressed tumor necrosis factor receptor-associated factor 1 group, although the difference was not significant. The clustering analysis showed that tumor necrosis factor receptor-associated factor 1 was most related to aldehyde dehydrogenase 1. These findings suggest that tumor necrosis factor receptor-associated factor 1 has potential direct/indirect regulations with the cancer stem cell markers in oral squamous cell carcinoma, which may help in further analysis of the cancer stem cell characteristics.
PMID
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Authors

Mayor MeshTerms
Keywords

Tumor necrosis factor receptor–associated factor 1

cancer stem cell

head neck cancer

inflammation

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28381191
OWN - NLM
STAT- MEDLINE
DA  - 20170406
DCOM- 20170418
LR  - 20170418
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 4
DP  - 2017 Apr
TI  - Expression and associations of TRAF1, BMI-1, ALDH1, and Lin28B in oral squamous
      cell carcinoma.
PG  - 1010428317695930
LID - 10.1177/1010428317695930 [doi]
AB  - Tumor necrosis factor receptor-associated factor 1, an adaptor protein of tumor
      necrosis factor 2, is involved in classical nuclear factor (NF)-kappaB activation
      and lymphocyte recruitment. However, less is known about the expression and
      association of tumor necrosis factor receptor-associated factor 1 with cancer
      stem cell markers in oral squamous cell carcinoma. This study aimed to
      investigate the expression of tumor necrosis factor receptor-associated factor 1 
      and stem cell characteristic markers (lin28 homolog B, B cell-specific Moloney
      murine leukemia virus integration site 1, and aldehyde dehydrogenase 1) in oral
      squamous cell carcinoma and analyze their relations. Paraffin-embedded tissues of
      78 oral squamous cell carcinomas, 39 normal oral mucosa, and 12 oral dysplasia
      tissues were employed in tissue microarrays, and the expression of tumor necrosis
      factor receptor-associated factor 1, B cell-specific Moloney murine leukemia
      virus integration site 1, aldehyde dehydrogenase 1, and lin28 homolog B was
      measured by immunohistostaining and digital pathological analysis. The expression
      of tumor necrosis factor receptor-associated factor 1 was higher in the oral
      squamous cell carcinoma group as compared with the expression in the oral mucosa 
      (p &lt; 0.01) and oral dysplasia (p &lt; 0.001) groups. In addition, the expression of 
      tumor necrosis factor receptor-associated factor 1 was associated with those of B
      cell-specific Moloney murine leukemia virus integration site 1, aldehyde
      dehydrogenase 1, and lin28 homolog B (p = 0.032, r2 = 0.109; p &lt; 0.0001, r2 =
      0.64; and p &lt; 0.001, r2 = 0.16) in oral squamous cell carcinoma. The patient
      survival rate was lower in the highly expressed tumor necrosis factor
      receptor-associated factor 1 group, although the difference was not significant. 
      The clustering analysis showed that tumor necrosis factor receptor-associated
      factor 1 was most related to aldehyde dehydrogenase 1. These findings suggest
      that tumor necrosis factor receptor-associated factor 1 has potential
      direct/indirect regulations with the cancer stem cell markers in oral squamous
      cell carcinoma, which may help in further analysis of the cancer stem cell
      characteristics.
FAU - Wu, Tian-Fu
AU  - Wu TF
AD  - 1 The State Key Laboratory Breeding Base of Basic Science of Stomatology &amp; Key
      Laboratory of Oral Biomedicine Ministry of Education, Wuhan University, Wuhan,
      People's Republic of China.
AD  - 2 Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of
      Stomatology, Wuhan University, Wuhan, People's Republic of China.
FAU - Li, Yi-Cun
AU  - Li YC
AD  - 1 The State Key Laboratory Breeding Base of Basic Science of Stomatology &amp; Key
      Laboratory of Oral Biomedicine Ministry of Education, Wuhan University, Wuhan,
      People's Republic of China.
FAU - Ma, Si-Rui
AU  - Ma SR
AD  - 1 The State Key Laboratory Breeding Base of Basic Science of Stomatology &amp; Key
      Laboratory of Oral Biomedicine Ministry of Education, Wuhan University, Wuhan,
      People's Republic of China.
FAU - Bing-Liu
AU  - Bing-Liu
AD  - 2 Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of
      Stomatology, Wuhan University, Wuhan, People's Republic of China.
FAU - Zhang, Wen-Feng
AU  - Zhang WF
AD  - 2 Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of
      Stomatology, Wuhan University, Wuhan, People's Republic of China.
FAU - Sun, Zhi-Jun
AU  - Sun ZJ
AD  - 1 The State Key Laboratory Breeding Base of Basic Science of Stomatology &amp; Key
      Laboratory of Oral Biomedicine Ministry of Education, Wuhan University, Wuhan,
      People's Republic of China.
AD  - 2 Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of
      Stomatology, Wuhan University, Wuhan, People's Republic of China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (BMI1 protein, human)
RN  - 0 (Biomarkers)
RN  - 0 (Isoenzymes)
RN  - 0 (LIN28B protein, human)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (TNF Receptor-Associated Factor 1)
RN  - EC 1.2.1.- (aldehyde dehydrogenase 1)
RN  - EC 1.2.1.36 (Retinal Dehydrogenase)
RN  - EC 2.3.2.27 (Polycomb Repressive Complex 1)
SB  - IM
MH  - Biomarkers
MH  - Carcinoma, Squamous Cell/*chemistry/mortality/pathology
MH  - Humans
MH  - Isoenzymes/*analysis
MH  - Mouth Neoplasms/*chemistry/mortality/pathology
MH  - Neoplastic Stem Cells/*chemistry
MH  - Polycomb Repressive Complex 1/*analysis
MH  - RNA-Binding Proteins/*analysis
MH  - Retinal Dehydrogenase/*analysis
MH  - TNF Receptor-Associated Factor 1/*analysis
OTO - NOTNLM
OT  - Tumor necrosis factor receptor-associated factor 1
OT  - cancer stem cell
OT  - head neck cancer
OT  - inflammation
EDAT- 2017/04/07 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/07 06:00
AID - 10.1177/1010428317695930 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Apr;39(4):1010428317695930. doi: 10.1177/1010428317695930.

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