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Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Amyotrophic Lateral Sclerosis in a Patient Developing Carbon Dioxide Narcosis.

Abstract We report a rare case of syndrome of inappropriate antidiuretic hormone secretion (SIADH) associated with amyotrophic lateral sclerosis (ALS). A 69-year-old man was admitted to our hospital with sustained hyponatremia. Hyposmolality with elevated urinary osmolality and sodium excretion was observed, which indicated SIADH. The treatment for SIADH was challenging; the patient developed carbon dioxide narcosis, which led to the diagnosis of ALS. After the initiation of noninvasive positive-pressure ventilation, the patient's serum sodium concentration normalized and became stable. Thus, ALS should be recognized as a possible cause of SIADH in the clinical setting.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title internal medicine (tokyo, japan)
Publication Year Start

 



PMID- 28381746
OWN - NLM
STAT- MEDLINE
DA  - 20170406
DCOM- 20170602
LR  - 20170609
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 56
IP  - 7
DP  - 2017
TI  - Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with
      Amyotrophic Lateral Sclerosis in a Patient Developing Carbon Dioxide Narcosis.
PG  - 797-803
LID - 10.2169/internalmedicine.56.7033 [doi]
AB  - We report a rare case of syndrome of inappropriate antidiuretic hormone secretion
      (SIADH) associated with amyotrophic lateral sclerosis (ALS). A 69-year-old man
      was admitted to our hospital with sustained hyponatremia. Hyposmolality with
      elevated urinary osmolality and sodium excretion was observed, which indicated
      SIADH. The treatment for SIADH was challenging; the patient developed carbon
      dioxide narcosis, which led to the diagnosis of ALS. After the initiation of
      noninvasive positive-pressure ventilation, the patient's serum sodium
      concentration normalized and became stable. Thus, ALS should be recognized as a
      possible cause of SIADH in the clinical setting.
FAU - Inoue, Yui
AU  - Inoue Y
AD  - Department of Internal Medicine, Osaka Red Cross Hospital, Japan.
FAU - Murakami, Takaaki
AU  - Murakami T
FAU - Nakamura, Takeshi
AU  - Nakamura T
FAU - Morita, Kyohei
AU  - Morita K
FAU - Kaneda, Daita
AU  - Kaneda D
FAU - Nishino, Ichizo
AU  - Nishino I
FAU - Hayashi, Tetsuya
AU  - Hayashi T
FAU - Shinoto, Yuya
AU  - Shinoto Y
FAU - Hatoko, Tomonobu
AU  - Hatoko T
FAU - Kato, Tomoko
AU  - Kato T
FAU - Yonemitsu, Shin
AU  - Yonemitsu S
FAU - Muro, Seiji
AU  - Muro S
FAU - Oki, Shogo
AU  - Oki S
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170401
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Aged
MH  - Amyotrophic Lateral Sclerosis/*complications
MH  - Carbon Dioxide/*adverse effects
MH  - Humans
MH  - Hyponatremia/complications
MH  - Inappropriate ADH Syndrome/*complications
MH  - Inert Gas Narcosis/*complications
MH  - Male
MH  - Osmolar Concentration
PMC - PMC5457923
EDAT- 2017/04/07 06:00
MHDA- 2017/06/03 06:00
CRDT- 2017/04/07 06:00
AID - 10.2169/internalmedicine.56.7033 [doi]
PST - ppublish
SO  - Intern Med. 2017;56(7):797-803. doi: 10.2169/internalmedicine.56.7033. Epub 2017 
      Apr 1.

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