PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.




PMID- 28383449
OWN - NLM
STAT- MEDLINE
DA  - 20170406
DCOM- 20170418
LR  - 20170418
IS  - 1530-0358 (Electronic)
IS  - 0012-3706 (Linking)
VI  - 60
IP  - 5
DP  - 2017 May
TI  - Differential Impact of Anastomotic Leak in Patients With Stage IV Colonic or
      Rectal Cancer: A Nationwide Cohort Study.
PG  - 497-507
LID - 10.1097/DCR.0000000000000761 [doi]
AB  - BACKGROUND: Anastomotic leak has a negative impact on the prognosis of patients
      who undergo colorectal cancer resection. However, data on anastomotic leak are
      limited for stage IV colorectal cancers. OBJECTIVE: The purpose of this study was
      to investigate the impact of anastomotic leak on survival and the decision to
      administer chemotherapy and/or metastasectomy after elective surgery for stage IV
      colorectal cancer. DESIGN: This was a nationwide, retrospective cohort study.
      SETTINGS: Data were obtained from the Danish Colorectal Cancer Group, the Danish 
      Pathology Registry, and the National Patient Registry. PATIENTS: Patients who
      were diagnosed with stage IV colorectal cancer between 2009 and 2013 and
      underwent elective resection of their primary tumors were included. MAIN OUTCOME 
      MEASURES: The primary outcome was all-cause mortality depending on the occurrence
      of anastomotic leak. Secondary outcomes were the administration of and time to
      adjuvant chemotherapy, metastasectomy rate, and risk factors for leak. RESULTS:
      Of the 774 patients with stage IV colorectal cancer who were included, 71 (9.2%) 
      developed anastomotic leaks. Anastomotic leak had a significant impact on the
      long-term survival of patients with colon cancer (p = 0.04) but not on those with
      rectal cancer (p = 0.91). Anastomotic leak was followed by the decreased
      administration of adjuvant chemotherapy in patients with colon cancer (p = 0.007)
      but not in patients with rectal cancer (p = 0.47). Finally, anastomotic leak had 
      a detrimental impact on metastasectomy rates after colon cancer but not on
      resection rates of rectal cancer. LIMITATIONS: Retrospective data on the
      selection criteria for primary tumor resection and metastatic tumor load were
      unavailable. CONCLUSIONS: The impact of anastomotic leak on patients differed
      between stage IV colon and rectal cancers. Survival and eligibility to receive
      chemotherapy and metastasectomy differed between patients with colon and rectal
      cancers. When planning for primary tumor resection, these factors should be
      considered.
FAU - Nordholm-Carstensen, Andreas
AU  - Nordholm-Carstensen A
AD  - 1 Digestive Disease Center, Bispebjerg Hospital, University of Copenhagen,
      Copenhagen, Denmark 2 Department of Surgical Gastroenterology, Rigshospitalet,
      University of Copenhagen, Copenhagen, Denmark.
FAU - Rolff, Hans Christian
AU  - Rolff HC
FAU - Krarup, Peter-Martin
AU  - Krarup PM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dis Colon Rectum
JT  - Diseases of the colon and rectum
JID - 0372764
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Anastomosis, Surgical/adverse effects/methods
MH  - *Anastomotic Leak/diagnosis/etiology/mortality
MH  - Chemotherapy, Adjuvant/methods
MH  - *Colectomy/adverse effects/methods
MH  - *Colorectal Neoplasms/mortality/pathology/surgery
MH  - Denmark/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
MH  - Outcome and Process Assessment (Health Care)
MH  - Prognosis
MH  - Registries
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Analysis
EDAT- 2017/04/07 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/07 06:00
AID - 10.1097/DCR.0000000000000761 [doi]
AID - 00003453-201705000-00006 [pii]
PST - ppublish
SO  - Dis Colon Rectum. 2017 May;60(5):497-507. doi: 10.1097/DCR.0000000000000761.

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