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IP-10 in occupational asthma: review of the literature and case-control study.

Abstract T-helper (Th)2 cytokines are thought to mediate most of the allergic inflammatory responses associated with atopic asthma. But the Th1-related chemokine, interferon (IFN)-γ-induced protein 10 (IP-10)/chemokine (C-X-C motif) ligand (CXCL)10, was the predominant chemokine measured during human allergic pulmonary late-phase reaction. Viral infection and allergens can exacerbate asthma by inducing the accumulation of these chemokines and inflammatory cells in the airway. Short-acting β2-adrenoreceptor agonists, budesonide and formoterol (all important relievers in asthma exacerbation), such as vitamin D3, vitamin C, have been shown to inhibit airway cells inflammatory responses by modulating these chemokines. Furthemore it has been suggested that Th1-related IP-10 and monokine induced by IFN-γ (MIG)/CXCL9 may be useful inflammatory markers of asthma exacerbation.
PMID
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Authors

Mayor MeshTerms
Keywords

Asthma

CXCR3 chemokines

IP-10

Occupational asthma

Th1 chemokines

Journal Title la clinica terapeutica
Publication Year Start




PMID- 28383629
OWN - NLM
STAT- In-Process
DA  - 20170406
LR  - 20170406
IS  - 1972-6007 (Electronic)
IS  - 0009-9074 (Linking)
VI  - 168
IP  - 2
DP  - 2017 Mar-Apr
TI  - IP-10 in occupational asthma: review of the literature and case-control study.
PG  - e151-e157
LID - 10.7417/CT.2017.1998 [doi]
AB  - OBJECTIVES: T-helper (Th)2 cytokines are thought to mediate most of the allergic 
      inflammatory responses associated with atopic asthma. But the Th1-related
      chemokine, interferon (IFN)-gamma-induced protein 10 (IP-10)/chemokine (C-X-C
      motif) ligand (CXCL)10, was the predominant chemokine measured during human
      allergic pulmonary late-phase reaction. Viral infection and allergens can
      exacerbate asthma by inducing the accumulation of these chemokines and
      inflammatory cells in the airway. Short-acting beta2-adrenoreceptor agonists,
      budesonide and formoterol (all important relievers in asthma exacerbation), such 
      as vitamin D3, vitamin C, have been shown to inhibit airway cells inflammatory
      responses by modulating these chemokines. Furthemore it has been suggested that
      Th1-related IP-10 and monokine induced by IFN-gamma (MIG)/CXCL9 may be useful
      inflammatory markers of asthma exacerbation. PATIENTS AND METHODS: In this study 
      we have evaluated serum levels of the Th1-related CXC chemokine IP-10, in 8
      patients with occupational asthma (OA) during exacerbation due to occupational
      exposure, and after 2-3 months, when patients were in stable conditions, in
      comparison with 8 age and gender matched healthy subjects. RESULTS: A significant
      increase in the serum levels of IP-10 were found in OA patients with an acute
      exacerbation in contrast to healthy controls (p<0.01), and in comparison with
      same OA patients after 2-3 months, when they were without any respiratory
      symptoms or disorders. CONCLUSIONS: These results suggest that the Th1-related
      CXC chemokines IP-10 is an useful inflammatory marker of OA exacerbation.
      However, other studies in larger number of patients are needed.
FAU - Ragusa, F
AU  - Ragusa F
AD  - Department of Translational Research and New Technologies in Medicine and
      Surgery, University of Pisa, Pisa.
FAU - Fallahi, P
AU  - Fallahi P
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa,
      Italy.
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Clin Ter
JT  - La Clinica terapeutica
JID - 0372604
OTO - NOTNLM
OT  - Asthma
OT  - CXCR3 chemokines
OT  - IP-10
OT  - Occupational asthma
OT  - Th1 chemokines
EDAT- 2017/04/07 06:00
MHDA- 2017/04/07 06:00
CRDT- 2017/04/07 06:00
PST - ppublish
SO  - Clin Ter. 2017 Mar-Apr;168(2):e151-e157. doi: 10.7417/CT.2017.1998.

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