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Evaluation of a Panel of Single-Nucleotide Polymorphisms in miR-146a and miR-196a2 Genomic Regions in Patients with Chronic Periodontitis.

Abstract Periodontitis is an inflammatory disease caused by bacterial triggering of the host immune-inflammatory response, which in turn is regulated by microRNAs (miRNA). Polymorphisms in the miRNA pathways affect the expression of several target genes such as tumor necrosis factor-α and interleukins, which are associated with progression of disease.
PMID
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Authors

Mayor MeshTerms
Keywords

chronic periodontitis

genotype

microRNA

single-nucleotide polymorphisms

Journal Title genetic testing and molecular biomarkers
Publication Year Start




PMID- 28384038
OWN - NLM
STAT- MEDLINE
DA  - 20170406
DCOM- 20170518
LR  - 20170518
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 21
IP  - 4
DP  - 2017 Apr
TI  - Evaluation of a Panel of Single-Nucleotide Polymorphisms in miR-146a and
      miR-196a2 Genomic Regions in Patients with Chronic Periodontitis.
PG  - 228-235
LID - 10.1089/gtmb.2016.0358 [doi]
AB  - BACKGROUND: Periodontitis is an inflammatory disease caused by bacterial
      triggering of the host immune-inflammatory response, which in turn is regulated
      by microRNAs (miRNA). Polymorphisms in the miRNA pathways affect the expression
      of several target genes such as tumor necrosis factor-alpha and interleukins,
      which are associated with progression of disease. OBJECTIVE: The objective of
      this study was to identify the association between the MiR-146a single nucleotide
      polymorphisms (SNPs) (rs2910164, rs57095329, and rs73318382), the MiR-196a2
      (rs11614913) SNP and chronic periodontitis. METHODS: Genotyping was performed for
      the MiR-146a (rs2910164, rs57095329, and rs73318382) and the MiR-196a2
      (rs11614913) polymorphisms in 180 healthy controls and 190 cases of chronic
      periodontitis by the direct Sanger sequencing technique. The strength of the
      association between the polymorphisms and chronic periodontitis was evaluated
      using logistic regression analysis. Haplotype and linkage analyses among the
      polymorphisms was performed. Multifactorial dimensionality reduction was
      performed to determine epistatic interaction among the polymorphisms. RESULTS:
      The MiR-196a2 polymorphism revealed a significant inverse association with
      chronic periodontitis. Haplotype analysis of MiR-146a and MiR-196a2 polymorphisms
      revealed 13 different combinations, of which 5 were found to have an inverse
      association with chronic periodontitis. CONCLUSION: The present study has
      demonstrated a significant inverse association of MiR-196a2 polymorphism with
      chronic periodontitis.
FAU - Venugopal, Priyanka
AU  - Venugopal P
AD  - 1 Department of Human Genetics, Sri Ramachandra University , Chennai, India .
FAU - Lavu, Vamsi
AU  - Lavu V
AD  - 2 Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra
      University , Chennai, India .
FAU - RangaRao, Suresh
AU  - RangaRao S
AD  - 2 Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra
      University , Chennai, India .
FAU - Venkatesan, Vettriselvi
AU  - Venkatesan V
AD  - 1 Department of Human Genetics, Sri Ramachandra University , Chennai, India .
LA  - eng
PT  - Journal Article
DEP - 20170221
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (MIRN146 microRNA, human)
RN  - 0 (MIRN196 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Nucleotides)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Chronic Periodontitis/etiology/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - India
MH  - Male
MH  - MicroRNAs/*genetics/metabolism
MH  - Middle Aged
MH  - Nucleotides
MH  - Polymorphism, Single Nucleotide
MH  - Tumor Necrosis Factor-alpha/genetics
OTO - NOTNLM
OT  - chronic periodontitis
OT  - genotype
OT  - microRNA
OT  - single-nucleotide polymorphisms
EDAT- 2017/04/07 06:00
MHDA- 2017/05/19 06:00
CRDT- 2017/04/07 06:00
AID - 10.1089/gtmb.2016.0358 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2017 Apr;21(4):228-235. doi: 10.1089/gtmb.2016.0358.
      Epub 2017 Feb 21.

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