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Genotyping of IL-4 -590 (C>T) Gene in Iraqi Asthma Patients.

Abstract This study is the first investigation in Iraq dealing with genotyping of IL-4 -590 (C>T) gene, especially in Iraqi patients with asthma. We studied forty-eight blood samples collected from patients with asthma and compared with age-matched 25 healthy individuals as controls. The polymorphism results of IL-4 -590 (C>T) gene by using amplification refractory mutation system (ARMS-PCR) showed the presence of C and T alleles and three genotypes (CC, CT, and TT). Interestingly the frequency of C allele and CC genotype was higher in patients with asthma in comparison with the same allele and genotype in control (P 1 × 10(-6)). This increase was associated with an increased risk factor of asthma (odds ratio [OR] 9.21; 95% confidence interval [CI] 3.58-23.71). Genotypes analysis by using Hardy-Weinberg distribution showed no significant differences between patients with asthma and healthy subjects. In conclusion, the increasing risk of asthma was associated with C allele and the CC genotype and these are revealed as etiological fraction with risk by having this disease, while the T allele percentage ratio in controls was higher when it is compared with asthma patients suggesting that these alleles have a protective effect (preventive fraction).
PMID
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Authors

Mayor MeshTerms

Polymorphism, Single Nucleotide

Keywords
Journal Title disease markers
Publication Year Start




PMID- 28386156
OWN - NLM
STAT- MEDLINE
DA  - 20170407
DCOM- 20170420
LR  - 20170420
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Linking)
VI  - 2017
DP  - 2017
TI  - Genotyping of IL-4 -590 (C>T) Gene in Iraqi Asthma Patients.
PG  - 5806236
LID - 10.1155/2017/5806236 [doi]
AB  - This study is the first investigation in Iraq dealing with genotyping of IL-4
      -590 (C>T) gene, especially in Iraqi patients with asthma. We studied forty-eight
      blood samples collected from patients with asthma and compared with age-matched
      25 healthy individuals as controls. The polymorphism results of IL-4 -590 (C>T)
      gene by using amplification refractory mutation system (ARMS-PCR) showed the
      presence of C and T alleles and three genotypes (CC, CT, and TT). Interestingly
      the frequency of C allele and CC genotype was higher in patients with asthma in
      comparison with the same allele and genotype in control (P 1 x 10-6). This
      increase was associated with an increased risk factor of asthma (odds ratio [OR] 
      9.21; 95% confidence interval [CI] 3.58-23.71). Genotypes analysis by using
      Hardy-Weinberg distribution showed no significant differences between patients
      with asthma and healthy subjects. In conclusion, the increasing risk of asthma
      was associated with C allele and the CC genotype and these are revealed as
      etiological fraction with risk by having this disease, while the T allele
      percentage ratio in controls was higher when it is compared with asthma patients 
      suggesting that these alleles have a protective effect (preventive fraction).
FAU - Hussein, Ihsan A
AU  - Hussein IA
AUID- ORCID: 0000-0002-2991-2113
AD  - Department of Biology, College of Education for Pure Science-Ibn Al-Haytham,
      University of Baghdad, Baghdad, Iraq.
FAU - Jaber, Saddam H
AU  - Jaber SH
AD  - Department of Biology, College of Education for Pure Science-Ibn Al-Haytham,
      University of Baghdad, Baghdad, Iraq.
LA  - eng
PT  - Journal Article
DEP - 20170312
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (IL4 protein, human)
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asthma/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - Genotype
MH  - Humans
MH  - Interleukin-4/*genetics
MH  - Iraq
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
PMC - PMC5366214
EDAT- 2017/04/08 06:00
MHDA- 2017/04/21 06:00
CRDT- 2017/04/08 06:00
PHST- 2016/12/01 [received]
PHST- 2017/02/12 [revised]
PHST- 2017/02/21 [accepted]
AID - 10.1155/2017/5806236 [doi]
PST - ppublish
SO  - Dis Markers. 2017;2017:5806236. doi: 10.1155/2017/5806236. Epub 2017 Mar 12.

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