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Crocin reduces the inflammation response in rheumatoid arthritis.

Abstract This study is to determine the role and mechanism of crocin in rheumatoid arthritis (RA). Totally 60 Wistar SD rats were randomly divided into control group, RA model group, methotrexate group, crocin high dose, middle dose, and low dose groups. The paw swelling degree, arthritis score, thymus and spleen index, the mRNA and protein levels of iNOS, and the serum content of TNF-α, IL-1β, and IL-6 were evaluated. Crocin treatment significantly alleviated the paw swelling of RA rats. The arthritis score in crocin treatment groups was significantly lower than that in RA model group. Additionally, the thymus index, but not the spleen index, declined remarkably in crocin treatment groups than in RA model group. Besides, crocin administration significantly reduced the iNOS production and the serum content of TNF-α, IL-1β, and IL-6. Crocin may exert potent anti-RA effects through inhibiting cytokine.
PMID
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Authors

Mayor MeshTerms
Keywords

F-α

IL-1β

IL-6

NOS

rheumatoid arthritis

Journal Title bioscience, biotechnology, and biochemistry
Publication Year Start




PMID- 28388359
OWN - NLM
STAT- MEDLINE
DA  - 20170407
DCOM- 20170419
LR  - 20170419
IS  - 1347-6947 (Electronic)
IS  - 0916-8451 (Linking)
VI  - 81
IP  - 5
DP  - 2017 May
TI  - Crocin reduces the inflammation response in rheumatoid arthritis.
PG  - 891-898
LID - 10.1080/09168451.2016.1263145 [doi]
AB  - This study is to determine the role and mechanism of crocin in rheumatoid
      arthritis (RA). Totally 60 Wistar SD rats were randomly divided into control
      group, RA model group, methotrexate group, crocin high dose, middle dose, and low
      dose groups. The paw swelling degree, arthritis score, thymus and spleen index,
      the mRNA and protein levels of iNOS, and the serum content of TNF-alpha,
      IL-1beta, and IL-6 were evaluated. Crocin treatment significantly alleviated the 
      paw swelling of RA rats. The arthritis score in crocin treatment groups was
      significantly lower than that in RA model group. Additionally, the thymus index, 
      but not the spleen index, declined remarkably in crocin treatment groups than in 
      RA model group. Besides, crocin administration significantly reduced the iNOS
      production and the serum content of TNF-alpha, IL-1beta, and IL-6. Crocin may
      exert potent anti-RA effects through inhibiting cytokine.
FAU - Li, Xiang
AU  - Li X
AD  - a Department of Pharmacy , Zaozhuang Municipal Hospital , Zaozhuang , P.R. China.
FAU - Jiang, Chao
AU  - Jiang C
AD  - b Department of Rehabilitation , Zaozhuang Municipal Hospital , Zaozhuang , P.R. 
      China.
FAU - Zhu, Wenyong
AU  - Zhu W
AD  - c Medical Department , Zaozhuang Municipal Hospital , Zaozhuang , P.R. China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Cytokines)
RN  - 0 (RNA, Messenger)
RN  - 36-88-4 (Carotenoids)
RN  - 877GWI46C2 (crocin)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
SB  - IM
MH  - Animals
MH  - Arthritis, Rheumatoid/blood/*drug therapy/immunology/pathology
MH  - Carotenoids/*pharmacology/therapeutic use
MH  - Cytokines/blood
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression Regulation, Enzymologic/drug effects
MH  - Inflammation/drug therapy
MH  - Male
MH  - Nitric Oxide Synthase Type II/genetics
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Spleen/drug effects/immunology
MH  - Thymus Gland/drug effects/immunology
OTO - NOTNLM
OT  - F-alpha
OT  - IL-1beta
OT  - IL-6
OT  - NOS
OT  - rheumatoid arthritis
EDAT- 2017/04/08 06:00
MHDA- 2017/04/20 06:00
CRDT- 2017/04/08 06:00
AID - 10.1080/09168451.2016.1263145 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2017 May;81(5):891-898. doi:
      10.1080/09168451.2016.1263145.

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