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PMID- 28390622
OWN - NLM
STAT- MEDLINE
DA  - 20170409
DCOM- 20170517
LR  - 20170517
IS  - 1872-8464 (Electronic)
IS  - 0165-5876 (Linking)
VI  - 96
DP  - 2017 May
TI  - The effect of caffeic acid phenethyl ester and thymoquinone on otitis media with 
      effusion in rats.
PG  - 94-99
LID - S0165-5876(17)30102-7 [pii]
LID - 10.1016/j.ijporl.2017.03.011 [doi]
AB  - OBJECTIVE: In this study, we aimed to investigate the effect of CAPE and
      thymoquinone in experimental rat otitis media with effusion (OME) model. METHODS:
      Intraoral approach of eustachian tube orifice cauterization were administered to 
      36 of 40 rats participating the study. After application of exclusion criterias, 
      22 rats with appropriate conditions were determined. Totally 26 rats (44 otitis
      model ears and 8 normal ears) were randomly divided into 5 groups. While group I 
      was consisted of healthy rats, the other groups were consisted of rats with
      otitis model. Group I (saline + control group; n = 8 normal ears) and group II
      (saline + otitis model; n = 10 otitis model ears) received intraperitoneally
      saline solution. CAPE was given intraperitoneally to group III (CAPE + otitis
      model; n = 12 otitis model ears) at a concentration of 10 mg/kg for treatment of 
      otitis media. Group IV (thymoquinone + otitis model; n = 12 otitis model ears)
      was treated orally with 10 mg/kg of thymoquinone. Group V (methylprednisolone +
      otitis model; n = 10 otitis model ears) was treated intraperitoneally with 1
      mg/kg of methylprednisolone. Tympanic bulla samples were excised after 10th day
      of treatment and examined under light microscopy. RESULTS: Submucosal neutrophil 
      leukocyte count of group I was significantly lower than other groups (II, IV, V) 
      (respectively p < 0,0001, p < 0,001, p < 0,0001, Tukey test), while it was not
      significantly different from group III (p = 0,056, Tukey test). Submucosal
      neutrophil leukocyte count of group III was significantly lower than group II and
      group V (p = 0.029 ve p = 0.03, Tukey test). There was no significant difference 
      between group IV and group V (p = 0,28, Tukey test). CONCLUSION: Based on these
      findings, it could be suggested that CAPE, anti inflammatory properties proven in
      the literature, plays an important role in OME treatment.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Gulmez, Mehmet Ihsan
AU  - Gulmez MI
AD  - Department of ENT and Head and Neck Surgery, Mustafa Kemal University, Medical
      Collage, 31030, Hatay, Turkey. Electronic address: [email protected]
FAU - Okuyucu, Semsettin
AU  - Okuyucu S
AD  - Department of ENT and Head and Neck Surgery, Mustafa Kemal University, Medical
      Collage, 31030, Hatay, Turkey. Electronic address: [email protected]
FAU - Dokuyucu, Recep
AU  - Dokuyucu R
AD  - Department of Physiology, Mustafa Kemal University, Medical Collage, 31030,
      Hatay, Turkey. Electronic address: [email protected]
FAU - Gokce, Hasan
AU  - Gokce H
AD  - Department of Pathology, Mustafa Kemal University, Medical Collage, 31030, Hatay,
      Turkey. Electronic address: [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170307
PL  - Ireland
TA  - Int J Pediatr Otorhinolaryngol
JT  - International journal of pediatric otorhinolaryngology
JID - 8003603
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Benzoquinones)
RN  - 0 (Caffeic Acids)
RN  - 490-91-5 (thymoquinone)
RN  - G960R9S5SK (caffeic acid phenethyl ester)
RN  - ML9LGA7468 (Phenylethyl Alcohol)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Benzoquinones/*pharmacology
MH  - Caffeic Acids/*pharmacology
MH  - Disease Models, Animal
MH  - Eustachian Tube
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Otitis Media with Effusion/*drug therapy
MH  - Phenylethyl Alcohol/*analogs & derivatives/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Temporal Bone
OTO - NOTNLM
OT  - Caffeic acid phenyl ester
OT  - Inflammation
OT  - Otitis media with effusion
OT  - Thymoquinone
EDAT- 2017/04/10 06:00
MHDA- 2017/05/18 06:00
CRDT- 2017/04/10 06:00
PHST- 2016/11/02 [received]
PHST- 2017/01/12 [revised]
PHST- 2017/03/04 [accepted]
AID - S0165-5876(17)30102-7 [pii]
AID - 10.1016/j.ijporl.2017.03.011 [doi]
PST - ppublish
SO  - Int J Pediatr Otorhinolaryngol. 2017 May;96:94-99. doi:
      10.1016/j.ijporl.2017.03.011. Epub 2017 Mar 7.

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