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Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis.

Abstract Background. Previous studies have revealed that gene polymorphisms of inflammatory factors may influence the development or progression of periodontitis, a main cause of tooth loss in adults; however, due to limitations of individual studies, inconsistent findings were reported. Objective. To meta-analytically investigate the relationship between periodontitis and the Interleukin-4 (IL-4) and Interleukin-4 receptor (IL-4R) gene polymorphisms. Methods. Databases were searched for relevant case-control studies. After study selection based on the predefined selection criteria, methodological quality assessment and data extraction were conducted independently by two reviewers, before subsequent statistical analyses. Results. 37 studies involving 4,385 patients and 5,168 controls were included. All the studied IL-4 polymorphisms were not significantly associated with periodontitis, except the -33C/T (CT versus CC: OR = 0.50, 95% CI = 0.28-0.88) associated with reduced AgP susceptibility. Positive association was found between IL-4R Q551 polymorphism and periodontitis susceptibility in three genetic models (R versus Q: OR = 1.59, 95% CI = 1.14-2.22; QR versus QQ: OR = 1.84, 95% CI = 1.21-2.80; RR + QR versus QQ: OR = 1.82, 95% CI = 1.22-2.72). Conclusions. A positive association exists between the IL-4R Q551R polymorphism and occurrence of CP. The IL-4 -33 CT genotype is negatively associated with the occurrence of AgP.
PMID
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Authors

Mayor MeshTerms

Genetic Predisposition to Disease

Polymorphism, Genetic

Keywords
Journal Title disease markers
Publication Year Start




PMID- 28392616
OWN - NLM
STAT- MEDLINE
DA  - 20170410
DCOM- 20170515
LR  - 20170515
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Linking)
VI  - 2017
DP  - 2017
TI  - Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A
      Meta-Analysis.
PG  - 8021279
LID - 10.1155/2017/8021279 [doi]
AB  - Background. Previous studies have revealed that gene polymorphisms of
      inflammatory factors may influence the development or progression of
      periodontitis, a main cause of tooth loss in adults; however, due to limitations 
      of individual studies, inconsistent findings were reported. Objective. To
      meta-analytically investigate the relationship between periodontitis and the
      Interleukin-4 (IL-4) and Interleukin-4 receptor (IL-4R) gene polymorphisms.
      Methods. Databases were searched for relevant case-control studies. After study
      selection based on the predefined selection criteria, methodological quality
      assessment and data extraction were conducted independently by two reviewers,
      before subsequent statistical analyses. Results. 37 studies involving 4,385
      patients and 5,168 controls were included. All the studied IL-4 polymorphisms
      were not significantly associated with periodontitis, except the -33C/T (CT
      versus CC: OR = 0.50, 95% CI = 0.28-0.88) associated with reduced AgP
      susceptibility. Positive association was found between IL-4R Q551 polymorphism
      and periodontitis susceptibility in three genetic models (R versus Q: OR = 1.59, 
      95% CI = 1.14-2.22; QR versus QQ: OR = 1.84, 95% CI = 1.21-2.80; RR + QR versus
      QQ: OR = 1.82, 95% CI = 1.22-2.72). Conclusions. A positive association exists
      between the IL-4R Q551R polymorphism and occurrence of CP. The IL-4 -33 CT
      genotype is negatively associated with the occurrence of AgP.
FAU - Jia, Xiao-Wei
AU  - Jia XW
AUID- ORCID: 0000-0003-1975-5932
AD  - Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West 
      Medicine, Guangzhou 510800, China.
FAU - Yuan, Ya-Di
AU  - Yuan YD
AUID- ORCID: 0000-0002-7030-5710
AD  - Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West 
      Medicine, Guangzhou 510800, China.
FAU - Yao, Zhong-Xiong
AU  - Yao ZX
AUID- ORCID: 0000-0001-6726-4949
AD  - Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West 
      Medicine, Guangzhou 510800, China.
FAU - Wu, Chang-Jing
AU  - Wu CJ
AUID- ORCID: 0000-0002-2616-9766
AD  - Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West 
      Medicine, Guangzhou 510800, China.
FAU - Chen, Xiang
AU  - Chen X
AUID- ORCID: 0000-0002-8647-9715
AD  - Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West 
      Medicine, Guangzhou 510800, China.
FAU - Chen, Xue-Hong
AU  - Chen XH
AD  - Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West 
      Medicine, Guangzhou 510800, China.
FAU - Lin, Ying-Mei
AU  - Lin YM
AUID- ORCID: 0000-0003-4897-6080
AD  - Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West 
      Medicine, Guangzhou 510800, China.
FAU - Meng, Xiang-Yu
AU  - Meng XY
AUID- ORCID: 0000-0001-5669-3502
AD  - Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan 
      University, Wuhan 430071, China.
FAU - Zeng, Xian-Tao
AU  - Zeng XT
AUID- ORCID: 0000-0003-1262-725X
AD  - Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan 
      University, Wuhan 430071, China.
FAU - Shao, Jun
AU  - Shao J
AUID- ORCID: 0000-0003-3478-5881
AD  - Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West 
      Medicine, Guangzhou 510800, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20170314
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (IL4 protein, human)
RN  - 0 (IL4R protein, human)
RN  - 0 (Interleukin-4 Receptor alpha Subunit)
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Chronic Periodontitis/*diagnosis/genetics/immunology
MH  - Gene Expression
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-4/*genetics/immunology
MH  - Interleukin-4 Receptor alpha Subunit/*genetics/immunology
MH  - Models, Genetic
MH  - *Polymorphism, Genetic
PMC - PMC5368398
EDAT- 2017/04/11 06:00
MHDA- 2017/05/16 06:00
CRDT- 2017/04/11 06:00
PHST- 2016/10/21 [received]
PHST- 2017/01/10 [revised]
PHST- 2017/02/08 [accepted]
AID - 10.1155/2017/8021279 [doi]
PST - ppublish
SO  - Dis Markers. 2017;2017:8021279. doi: 10.1155/2017/8021279. Epub 2017 Mar 14.

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