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Anal High-Grade Squamous Intraepithelial Lesions in Human Immunodeficiency Virus-Infected Men: A Study of 100 Cases With Emphasis on Cytohistologic Correlation.

Abstract Anorectal cytology (ARC) is a widely used screening tool for anal cancer in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). Its diagnostic accuracy needs to be improved, especially for high-grade squamous intraepithelial lesions (HSILs).
PMID
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Authors

Mayor MeshTerms
Keywords

Anal high-grade squamous intraepithelial lesions

Anorectal cytology

HIV-infected MSM

Journal Title american journal of clinical pathology
Publication Year Start




PMID- 28395054
OWN - NLM
STAT- MEDLINE
DA  - 20170410
DCOM- 20170414
LR  - 20170414
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 147
IP  - 3
DP  - 2017 Mar 01
TI  - Anal High-Grade Squamous Intraepithelial Lesions in Human Immunodeficiency
      Virus-Infected Men: A Study of 100 Cases With Emphasis on Cytohistologic
      Correlation.
PG  - 315-321
LID - 10.1093/ajcp/aqw229 [doi]
AB  - Objectives: Anorectal cytology (ARC) is a widely used screening tool for anal
      cancer in human immunodeficiency virus (HIV)-infected men who have sex with men
      (MSM). Its diagnostic accuracy needs to be improved, especially for high-grade
      squamous intraepithelial lesions (HSILs). Methods: Using 100 HIV+ MSM with
      biopsy-proven anal HSILs, we correlated histologic/cytologic findings. Results:
      Upon review, HSIL cells were present in 58 cytology samples and absent in 42.
      Positive samples were higher in cellularity and contained transformation zones ( 
      P < .05). Cytology was able to predict HSILs in 36%, 48%, 68%, and 78% of
      patients with one, two, three, and four or more high-grade lesions. HSIL cells
      were identified in all cytology samples initially reported as HSILs or atypical
      squamous cells, cannot exclude HSIL and in 34 samples reported as low-grade
      squamous intraepithelial lesions or less. Notably, among this last category, 15
      (44%) were keratinized-type HSILs. Conclusions: Our findings should improve the
      ARC detection rate for anal HSILs, helping to implement ARC as the primary
      screening tool for anal cancer.
FAU - Liu, Yuxin
AU  - Liu Y
AD  - From the Division of Gynecologic Pathology.
FAU - Wang, Xiaofei
AU  - Wang X
AD  - Division of Cytology, Department of Pathology, University of Massachusetts
      Medical School, UMass Memorial Medical Center, Worcester.
FAU - Kalir, Tamara
AU  - Kalir T
AD  - From the Division of Gynecologic Pathology.
FAU - Chhieng, David
AU  - Chhieng D
AD  - Division of Cytology, Department of Pathology.
FAU - Sigel, Keith
AU  - Sigel K
AD  - Division of General Internal Medicine, Department of Medicine, Icahn School of
      Medicine at Mount Sinai, Mount Sinai Health System, New York, NY.
FAU - Gaisa, Michael M
AU  - Gaisa MM
AD  - Division of General Internal Medicine, Department of Medicine, Icahn School of
      Medicine at Mount Sinai, Mount Sinai Health System, New York, NY.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
SB  - AIM
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anus Neoplasms/*diagnosis/pathology/virology
MH  - Carcinoma in Situ/*diagnosis/pathology/virology
MH  - Carcinoma, Squamous Cell/*diagnosis/pathology/virology
MH  - Cytodiagnosis/*methods
MH  - Early Detection of Cancer/methods
MH  - HIV Infections/*complications
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Young Adult
OTO - NOTNLM
OT  - Anal high-grade squamous intraepithelial lesions
OT  - Anorectal cytology
OT  - HIV-infected MSM
EDAT- 2017/04/11 06:00
MHDA- 2017/04/15 06:00
CRDT- 2017/04/11 06:00
AID - 3053469 [pii]
AID - 10.1093/ajcp/aqw229 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2017 Mar 1;147(3):315-321. doi: 10.1093/ajcp/aqw229.

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