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What Is the Clinical Utility of Repeat SNP Array Testing in the Follow-up of Myeloid Neoplasms?: A Retrospective Analysis of 44 Patients With Serial SNP Arrays.

Abstract Single-nucleotide polymorphism (SNP) arrays have been shown to identify cytogenetic abnormalities in myeloid neoplasms that may be missed by metaphase cytogenetics alone at initial diagnosis. This study examines the utility of serial SNP arrays in follow-up testing of myeloid neoplasms.
PMID
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Authors

Mayor MeshTerms

Chromosome Aberrations

Keywords

Clonal evolution

Cytogenetics

Myelodysplastic syndrome

Myeloid neoplasm

Single-nucleotide polymorphism array

Journal Title american journal of clinical pathology
Publication Year Start




PMID- 28395056
OWN - NLM
STAT- MEDLINE
DA  - 20170410
DCOM- 20170414
LR  - 20170414
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 147
IP  - 3
DP  - 2017 Mar 01
TI  - What Is the Clinical Utility of Repeat SNP Array Testing in the Follow-up of
      Myeloid Neoplasms?: A Retrospective Analysis of 44 Patients With Serial SNP
      Arrays.
PG  - 278-284
LID - 10.1093/ajcp/aqx003 [doi]
AB  - Objectives: Single-nucleotide polymorphism (SNP) arrays have been shown to
      identify cytogenetic abnormalities in myeloid neoplasms that may be missed by
      metaphase cytogenetics alone at initial diagnosis. This study examines the
      utility of serial SNP arrays in follow-up testing of myeloid neoplasms. Methods: 
      We retrospectively reviewed results of SNP array testing in 44 patients with
      myeloid neoplasms and more than one SNP array study (n = 133 SNP arrays total;
      median, three per patient; range, two to eight per patient). Results: Baseline
      abnormalities were identified by SNP array in 35 (79%) of 44 (79%) compared with 
      18 (50%) of 36 by metaphase karyotype. In follow-up studies, clonal evolution was
      found by both SNP array and karyotyping in seven (15.9%), by metaphase
      karyotyping alone in six (13.6%), and SNP arrays alone in two (4.5%). Overall
      survival was not significantly different between patients with or without clonal 
      evolution detected by SNP array. Conclusions: This study, the first systematic
      examination of serial SNP arrays in myeloid neoplasms, confirms the clinical
      utility of SNP arrays at initial diagnosis but shows that clonal evolution of the
      karyotype can be detected by metaphase cytogenetics alone in most patients.
      Follow-up SNP array testing is not required in routine clinical use in most
      cases.
FAU - Basha, Basma
AU  - Basha B
AD  - From the Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH.
FAU - Smith, Janice
AU  - Smith J
AD  - Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, 
      TX.
FAU - Rogers, Heesun J
AU  - Rogers HJ
AD  - From the Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH.
FAU - Cook, James R
AU  - Cook JR
AD  - From the Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
SB  - AIM
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics/mortality
MH  - Myeloproliferative Disorders/*genetics/mortality
MH  - Oligonucleotide Array Sequence Analysis
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Clonal evolution
OT  - Cytogenetics
OT  - Myelodysplastic syndrome
OT  - Myeloid neoplasm
OT  - Single-nucleotide polymorphism array
EDAT- 2017/04/11 06:00
MHDA- 2017/04/15 06:00
CRDT- 2017/04/11 06:00
AID - 3053471 [pii]
AID - 10.1093/ajcp/aqx003 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2017 Mar 1;147(3):278-284. doi: 10.1093/ajcp/aqx003.

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