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PMID- 28395104
DA  - 20170410
DCOM- 20170414
LR  - 20170414
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 147
IP  - 2
DP  - 2017 Feb 01
TI  - HHV8/KSHV-Positive Lymphoproliferative Disorders and the Spectrum of
      Plasmablastic and Plasma Cell Neoplasms: 2015 SH/EAHP Workshop Report-Part 3.
PG  - 171-187
LID - 10.1093/ajcp/aqw218 [doi]
AB  - Objectives: The 2015 Workshop of the Society for Hematopathology/European
      Association for Haematopathology aimed to review immunodeficiency-related
      lymphoproliferative disorders with plasmablastic and plasma cell differentiation.
      Methods: The workshop panel reviewed human herpes virus 8 (HHV8)/Kaposi sarcoma
      herpesvirus (KSHV)-associated lesions and other lesions exhibiting plasma cell
      differentiation, including plasmablastic proliferations with features of
      myeloma/plasmacytoma, plasmablastic neoplasms presenting in extranodal sites and 
      effusion-based lymphomas, and rendered a consensus diagnosis. Results: The
      spectrum of HHV8/KSHV-associated proliferations ranged from multicentric
      Castleman disease (MCD) to MCD with plasmablastic aggregates to HHV8+ diffuse
      large B-cell lymphoma and germinotrophic lymphoproliferative disorder.
      Comparisons across effusion-based lymphomas with and without HHV8/KSHV and
      plasmablastic lymphomas in immunodeficient and immunocompetent patients were
      discussed. Conclusions: The presence or absence of HHV8/KSHV is a defining
      feature in disorders associated with Castleman disease, although their
      differential diagnosis and recognition of progression may be challenging.
      Plasmablastic proliferations overlap with myeloma/plasmacytoma as well as
      extranodal and effusion-based lymphomas. The involvement of Epstein-Barr virus is
      typically variable.
FAU - Chadburn, Amy
AU  - Chadburn A
AD  - From the Weill Medical College of Cornell University, New York, NY.
FAU - Said, Jonathan
AU  - Said J
AD  - University of California Los Angeles Medical Center, Los Angeles.
FAU - Gratzinger, Dita
AU  - Gratzinger D
AD  - Stanford University School of Medicine, Stanford, CA.
FAU - Chan, John K C
AU  - Chan JK
AD  - Queen Elizabeth Hospital, Kowloon, Hong Kong.
FAU - de Jong, Daphne
AU  - de Jong D
AD  - VU University Medical Center, Amsterdam, the Netherlands.
FAU - Jaffe, Elaine S
AU  - Jaffe ES
AD  - National Institutes of Health, Bethesda, MD.
FAU - Natkunam, Yasodha
AU  - Natkunam Y
AD  - Stanford University School of Medicine, Stanford, CA.
FAU - Goodlad, John R
AU  - Goodlad JR
AD  - University of Leeds, Leeds, UK.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
SB  - IM
MH  - Adult
MH  - Aged
MH  - Education
MH  - Female
MH  - Herpesviridae Infections/*complications
MH  - Herpesvirus 8, Human
MH  - Humans
MH  - Immunologic Deficiency Syndromes/*pathology/virology
MH  - Lymphoproliferative Disorders/diagnosis/*pathology/virology
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Plasma Cell/diagnosis/*pathology/virology
OT  - Germinotropic lymphoproliferative disorder
OT  - HHV8
OT  - Multicentric Castleman disease
OT  - Plasmablastic lymphoma
OT  - Primary effusion lymphoma
EDAT- 2017/04/11 06:00
MHDA- 2017/04/15 06:00
CRDT- 2017/04/11 06:00
AID - 3041112 [pii]
AID - 10.1093/ajcp/aqw218 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2017 Feb 1;147(2):171-187. doi: 10.1093/ajcp/aqw218.

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