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PMID- 28395105
DA  - 20170410
DCOM- 20170414
LR  - 20170414
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 147
IP  - 2
DP  - 2017 Feb 01
TI  - T- and NK-Cell Lymphomas and Systemic Lymphoproliferative Disorders and the
      Immunodeficiency Setting: 2015 SH/EAHP Workshop Report-Part 4.
PG  - 188-203
LID - 10.1093/ajcp/aqw213 [doi]
AB  - Objectives: The 2015 Workshop of the Society for Hematopathology/European
      Association for Haematopathology aimed to review immunodeficiency-related T- and 
      natural killer (NK)-cell lymphoproliferations. Methods: The Workshop Panel
      reviewed 88 T- or NK-cell lymphoproliferations and rendered consensus diagnoses. 
      Results: Hyperplasias of T-cell subsets may be clonal; retained architecture and 
      the clinical setting support a benign diagnosis. Specific associations include
      hepatosplenic T-cell lymphoma with iatrogenic immunosuppression and breast
      implants with an indolent variant of anaplastic large cell lymphoma. Epstein-Barr
      virus (EBV)-positive T-cell lymphomas rarely occur in the acquired
      immunodeficiency setting. Systemic T- and NK-cell lymphoma of childhood overlaps 
      with chronic active EBV and reversible hemophagocytic lymphohistiocytosis-related
      T-cell lymphoproliferations. Conclusions: Immunodeficiencies predispose to T-cell
      hyperplasias, which must not be overdiagnosed as lymphoma. Many T-cell lymphomas 
      in the immunodeficiency setting are likely coincidental, with specific
      exceptions. Systemic T- or NK-cell lymphomas are part of a spectrum of EBV+ T or 
      NK lymphoproliferations and can present in the acquired immunodeficiency setting.
FAU - Gratzinger, Dita
AU  - Gratzinger D
AD  - From the Stanford University School of Medicine, Stanford, CA.
FAU - de Jong, Daphne
AU  - de Jong D
AD  - VU University Medical Center, Amsterdam, the Netherlands.
FAU - Jaffe, Elaine S
AU  - Jaffe ES
AD  - National Institutes of Health, Bethesda, MD.
FAU - Chadburn, Amy
AU  - Chadburn A
AD  - Weill Medical College of Cornell University, New York, NY.
FAU - Chan, John K C
AU  - Chan JK
AD  - Queen Elizabeth Hospital, Kowloon, Hong Kong.
FAU - Goodlad, John R
AU  - Goodlad JR
AD  - University of Leeds, Leeds, United Kingdom.
FAU - Said, Jonathan
AU  - Said J
AD  - University of California Los Angeles Medical Center, Los Angeles.
FAU - Natkunam, Yasodha
AU  - Natkunam Y
AD  - From the Stanford University School of Medicine, Stanford, CA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
SB  - IM
MH  - Education
MH  - Epstein-Barr Virus Infections/complications
MH  - Female
MH  - Humans
MH  - Immunologic Deficiency Syndromes/*complications/immunology
MH  - Lymphoma, Extranodal NK-T-Cell/*diagnosis/immunology
MH  - Lymphoma, T-Cell/*diagnosis/immunology
MH  - Lymphoproliferative Disorders/*diagnosis/immunology
MH  - Male
OT  - Iatrogenic immunodeficiency
OT  - NK-cell lymphoma
OT  - Posttransplant lymphoproliferative disorder
OT  - Systemic T- or NK-cell lymphoma of childhood
OT  - T-cell lymphoma
EDAT- 2017/04/11 06:00
MHDA- 2017/04/15 06:00
CRDT- 2017/04/11 06:00
AID - 3045138 [pii]
AID - 10.1093/ajcp/aqw213 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2017 Feb 1;147(2):188-203. doi: 10.1093/ajcp/aqw213.

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