EBV-Positive B-Cell Proliferations of Varied Malignant Potential: 2015 SH/EAHP Workshop Report-Part 1.
|Abstract||The 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology aimed to review B-cell proliferations of varied malignant potential associated with immunodeficiency.|
Initial spontaneous remission of posttransplantation Epstein Barr virus-related B-cell lymphoproliferative disorder of the skin in a renal transplant recipient: case report and review of the literature on cutaneous B-cell posttransplantation lymphoproliferative disease.
|Journal Title||american journal of clinical pathology|
|Publication Year Start||2017-01-01|
PMID- 28395107 OWN - NLM STAT- MEDLINE DA - 20170410 DCOM- 20170414 LR - 20170414 IS - 1943-7722 (Electronic) IS - 0002-9173 (Linking) VI - 147 IP - 2 DP - 2017 Feb 01 TI - EBV-Positive B-Cell Proliferations of Varied Malignant Potential: 2015 SH/EAHP Workshop Report-Part 1. PG - 129-152 LID - 10.1093/ajcp/aqw214 [doi] AB - Objectives: The 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology aimed to review B-cell proliferations of varied malignant potential associated with immunodeficiency. Methods: The Workshop Panel reviewed all cases of B-cell hyperplasias, polymorphic B-lymphoproliferative disorders, Epstein-Barr virus (EBV)-positive mucocutaneous ulcer, and large B-cell proliferations associated with chronic inflammation and rendered consensus diagnoses. Disease definitions, boundaries with more aggressive B-cell proliferations, and association with EBV were explored. Results: B-cell proliferations of varied malignant potential occurred in all immunodeficiency backgrounds. Presentation early in the course of immunodeficiency and in younger age groups and regression with reduction of immunosuppression were characteristic features. EBV positivity was essential for diagnosis in some hyperplasias where other specific defining features were absent. Conclusions: This spectrum of B-cell proliferations show similarities across immunodeficiency backgrounds. Localized forms of immunodeficiency disorders arise in immunocompetent patients most likely due to chronic immune stimulation and, despite aggressive histologic features, often show indolent clinical behavior. FAU - Natkunam, Yasodha AU - Natkunam Y AD - From the Stanford University School of Medicine, Stanford, CA. FAU - Goodlad, John R AU - Goodlad JR AD - HMDS, St James's University Hospital, Leeds, United Kingdom. FAU - Chadburn, Amy AU - Chadburn A AD - Weill Medical College of Cornell University, New York, NY. FAU - de Jong, Daphne AU - de Jong D AD - VU University Medical Center, Amsterdam, the Netherlands. FAU - Gratzinger, Dita AU - Gratzinger D AD - From the Stanford University School of Medicine, Stanford, CA. FAU - Chan, John K C AU - Chan JK AD - Queen Elizabeth Hospital, Kowloon, Hong Kong. FAU - Said, Jonathan AU - Said J AD - University of California Los Angeles Medical Center, Los Angeles. FAU - Jaffe, Elaine S AU - Jaffe ES AD - National Institutes of Health, Bethesda, MD. LA - eng PT - Journal Article PL - England TA - Am J Clin Pathol JT - American journal of clinical pathology JID - 0370470 SB - AIM SB - IM MH - Adult MH - Aged MH - B-Lymphocytes/*pathology/virology MH - Child MH - Child, Preschool MH - Education MH - Epstein-Barr Virus Infections/*pathology MH - Female MH - Humans MH - Lymphoproliferative Disorders/*pathology/virology MH - Male MH - Middle Aged MH - Young Adult OTO - NOTNLM OT - Autoimmune OT - EBV OT - Early lesion OT - HIV OT - Iatrogenic OT - Nondestructive lesion OT - Polymorphic lymphoproliferative disorder OT - Posttransplant lymphoproliferative disorder EDAT- 2017/04/11 06:00 MHDA- 2017/04/15 06:00 CRDT- 2017/04/11 06:00 AID - 3052659 [pii] AID - 10.1093/ajcp/aqw214 [doi] PST - ppublish SO - Am J Clin Pathol. 2017 Feb 1;147(2):129-152. doi: 10.1093/ajcp/aqw214.
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