B-Cell and Classical Hodgkin Lymphomas Associated With Immunodeficiency: 2015 SH/EAHP Workshop Report-Part 2.
|Abstract||The 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology submitted small and large B-cell lymphomas (BCLs), including classical Hodgkin lymphoma (CHL), in the context of immunodeficiency.|
High incidence of Epstein-Barr virus (EBV)-positive Hodgkin lymphoma and Hodgkin lymphoma-like B-cell lymphoproliferations with EBV latency profile 2 in children with interleukin-2-inducible T-cell kinase deficiency.
A malignant lymphoma with histological features and immunophenotypic profile intermediate between EBV-positive diffuse large B-cell lymphoma and EBV-positive classical Hodgkin lymphoma in a 67-year-old female: a "gray zone" lymphoma associated with Epstein-Barr virus in the elderly.
|Journal Title||american journal of clinical pathology|
|Publication Year Start||2017-01-01|
PMID- 28395108 OWN - NLM STAT- MEDLINE DA - 20170410 DCOM- 20170414 LR - 20170414 IS - 1943-7722 (Electronic) IS - 0002-9173 (Linking) VI - 147 IP - 2 DP - 2017 Feb 01 TI - B-Cell and Classical Hodgkin Lymphomas Associated With Immunodeficiency: 2015 SH/EAHP Workshop Report-Part 2. PG - 153-170 LID - 10.1093/ajcp/aqw216 [doi] AB - Objectives: The 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology submitted small and large B-cell lymphomas (BCLs), including classical Hodgkin lymphoma (CHL), in the context of immunodeficiency. Methods: Clinicopathologic and molecular features were studied to explore unifying concepts in malignant B-cell proliferations across immunodeficiency settings. Results: Cases submitted to the workshop spanned small BCLs presenting as nodal or extranodal marginal zone lymphoma and lymphoplasmacytic lymphoma, Epstein-Barr virus (EBV) positive in 75% of cases. Submitted large BCLs formed a spectrum from diffuse large B-cell lymphoma (DLBCL) to CHL across immunodeficiency settings. Additional studies demonstrated overexpression of PD-L1 and molecular 9p24 alterations in the large BCL spectrum and across different immunodeficiency settings. Conclusions: Small BCLs occur in all immunodeficiency settings, and EBV positivity is essential for their recognition as immunodeficiency related. Large BCLs include a spectrum from DLBCL to CHL across all immunodeficiency settings; immunohistochemical and molecular features are suggestive of shared pathogenetic mechanisms involving PD-L1 immune checkpoints. FAU - de Jong, Daphne AU - de Jong D AD - From the VU University Medical Center, Amsterdam, the Netherlands. FAU - Roemer, Margaretha G M AU - Roemer MG AD - From the VU University Medical Center, Amsterdam, the Netherlands. AD - Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA. FAU - Chan, John K C AU - Chan JK AD - Queen Elizabeth Hospital, Kowloon, Hong Kong. FAU - Goodlad, John AU - Goodlad J AD - HMDS, St James's University Hospital, Leeds, United Kingdom. FAU - Gratzinger, Dita AU - Gratzinger D AD - Stanford University School of Medicine, Stanford, CA. FAU - Chadburn, Amy AU - Chadburn A AD - Weill Medical College of Cornell University, New York. FAU - Jaffe, Elaine S AU - Jaffe ES AD - National Institutes of Health, Bethesda, MD. FAU - Said, Jonathan AU - Said J AD - University of California Los Angeles Medical Center, Los Angeles. FAU - Natkunam, Yasodha AU - Natkunam Y AD - Stanford University School of Medicine, Stanford, CA. LA - eng PT - Journal Article PL - England TA - Am J Clin Pathol JT - American journal of clinical pathology JID - 0370470 SB - AIM SB - IM MH - Education MH - Epstein-Barr Virus Infections/*complications MH - Female MH - *Hodgkin Disease/immunology/pathology/virology MH - Humans MH - *Immunologic Deficiency Syndromes/immunology/pathology/virology MH - *Lymphoma, B-Cell/immunology/pathology/virology MH - Male OTO - NOTNLM OT - 9p24 OT - Autoimmunity OT - Classical Hodgkin lymphoma OT - Iatrogenic immunodeficiency OT - Large B-cell lymphoma OT - Marginal zone lymphoma OT - PD-L1 OT - Posttransplant lymphoproliferative disorder OT - Primary immunodeficiency OT - T-cell/histiocyte-rich B-cell lymphoma EDAT- 2017/04/11 06:00 MHDA- 2017/04/15 06:00 CRDT- 2017/04/11 06:00 AID - 3052661 [pii] AID - 10.1093/ajcp/aqw216 [doi] PST - ppublish SO - Am J Clin Pathol. 2017 Feb 1;147(2):153-170. doi: 10.1093/ajcp/aqw216.
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