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Efficacy and speed of kill of a new spot-on formulation of selamectin plus sarolaner against flea infestations in cats.

Abstract The efficacy of a new spot-on formulation of selamectin plus sarolaner against induced flea infestations in cats was confirmed in three placebo-controlled, blinded studies. Purpose-bred adult cats (n=8/group) were blocked by pre-treatment flea counts and randomly allocated to treatment with either a placebo or with the spot-on formulation at the minimum dose of 6.0mg selamectin and 1.0mg sarolaner per kg bodyweight. Treatments were applied topically once on Day 0. All cats were infested with approximately 100 unfed, adult Ctenocephalides felis prior to treatment and at weekly intervals for 5 weeks. In Studies 1 and 2 comb counts were conducted to determine the numbers of viable fleas 24h after treatment and subsequent weekly infestations. In Study 3, flea counts were conducted at 6, 12, 24 and 48h after treatment and 3, 6, 12 and 24h after subsequent weekly infestations to evaluate the speed of kill against fleas. Cats in the placebo-treated groups maintained flea infestations throughout all studies. In Study 1, no live fleas were found on any of the treated cats, resulting in 100% efficacy for 5 weeks after a single treatment (P≤0.0001). In Study 2, selamectin/sarolaner reduced flea counts by 92.4% immediately after treatment and by 97.7%-100% after re-infestations for five weeks (P≤0.0001). In the speed of kill study, selamectin/sarolaner started killing fleas within 12h after treatment administration and within 6h following re-infestation for at least 28days. Efficacy was 98.1% by 24h after treatment and 100% within 24h after re-infestations for 5 weeks. A single topical administration of a new spot-on formulation of selamectin plus sarolaner at the minimum dose rapidly and consistently kills fleas on cats for at least 5 weeks.
PMID
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Efficacy of a new spot-on formulation of selamectin plus sarolaner for cats against adult Ctenocephalides felis, flea egg production and adult flea emergence.

Authors

Mayor MeshTerms
Keywords

Cat

Flea

Revolution

Sarolaner

Selamectin

Speed of kill

Stronghold

Journal Title veterinary parasitology
Publication Year Start




PMID- 28395751
OWN - NLM
STAT- MEDLINE
DA  - 20170411
DCOM- 20170418
LR  - 20170418
IS  - 1873-2550 (Electronic)
IS  - 0304-4017 (Linking)
VI  - 238 Suppl 1
DP  - 2017 Apr
TI  - Efficacy and speed of kill of a new spot-on formulation of selamectin plus
      sarolaner against flea infestations in cats.
PG  - S18-S21
LID - S0304-4017(17)30104-8 [pii]
LID - 10.1016/j.vetpar.2017.03.010 [doi]
AB  - The efficacy of a new spot-on formulation of selamectin plus sarolaner against
      induced flea infestations in cats was confirmed in three placebo-controlled,
      blinded studies. Purpose-bred adult cats (n=8/group) were blocked by
      pre-treatment flea counts and randomly allocated to treatment with either a
      placebo or with the spot-on formulation at the minimum dose of 6.0mg selamectin
      and 1.0mg sarolaner per kg bodyweight. Treatments were applied topically once on 
      Day 0. All cats were infested with approximately 100 unfed, adult Ctenocephalides
      felis prior to treatment and at weekly intervals for 5 weeks. In Studies 1 and 2 
      comb counts were conducted to determine the numbers of viable fleas 24h after
      treatment and subsequent weekly infestations. In Study 3, flea counts were
      conducted at 6, 12, 24 and 48h after treatment and 3, 6, 12 and 24h after
      subsequent weekly infestations to evaluate the speed of kill against fleas. Cats 
      in the placebo-treated groups maintained flea infestations throughout all
      studies. In Study 1, no live fleas were found on any of the treated cats,
      resulting in 100% efficacy for 5 weeks after a single treatment (P</=0.0001). In 
      Study 2, selamectin/sarolaner reduced flea counts by 92.4% immediately after
      treatment and by 97.7%-100% after re-infestations for five weeks (P</=0.0001). In
      the speed of kill study, selamectin/sarolaner started killing fleas within 12h
      after treatment administration and within 6h following re-infestation for at
      least 28days. Efficacy was 98.1% by 24h after treatment and 100% within 24h after
      re-infestations for 5 weeks. A single topical administration of a new spot-on
      formulation of selamectin plus sarolaner at the minimum dose rapidly and
      consistently kills fleas on cats for at least 5 weeks.
CI  - Copyright (c) 2017 Zoetis Services LLC. Published by Elsevier B.V. All rights
      reserved.
FAU - Becskei, Csilla
AU  - Becskei C
AD  - Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20,
      Zaventem B-1930, Belgium. Electronic address: [email protected]
FAU - Cherni, Judith A
AU  - Cherni JA
AD  - Zoetis, Veterinary Medicine Research and Development, 333 Portage Street,
      Kalamazoo, MI 49007, USA.
FAU - Vatta, Adriano F
AU  - Vatta AF
AD  - Zoetis, Veterinary Medicine Research and Development, 333 Portage Street,
      Kalamazoo, MI 49007, USA.
FAU - King, Vickie L
AU  - King VL
AD  - Zoetis, Veterinary Medicine Research and Development, 333 Portage Street,
      Kalamazoo, MI 49007, USA.
FAU - Lin, Dan
AU  - Lin D
AD  - Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20,
      Zaventem B-1930, Belgium.
FAU - Rugg, Douglas
AU  - Rugg D
AD  - Zoetis, Veterinary Medicine Research and Development, 333 Portage Street,
      Kalamazoo, MI 49007, USA.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Vet Parasitol
JT  - Veterinary parasitology
JID - 7602745
RN  - 0 (Antiparasitic Agents)
RN  - 0 (Isoxazoles)
RN  - 70288-86-7 (Ivermectin)
RN  - A2669OWX9N (selamectin)
SB  - IM
MH  - Administration, Topical
MH  - Animals
MH  - Antiparasitic Agents/administration & dosage
MH  - Cat Diseases/*drug therapy
MH  - Cats
MH  - Female
MH  - Flea Infestations/drug therapy/*veterinary
MH  - Isoxazoles/*administration & dosage
MH  - Ivermectin/administration & dosage/*analogs & derivatives
MH  - Male
MH  - Random Allocation
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Cat
OT  - Flea
OT  - Revolution
OT  - Sarolaner
OT  - Selamectin
OT  - Speed of kill
OT  - Stronghold
EDAT- 2017/04/12 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/12 06:00
PHST- 2017/01/10 [received]
PHST- 2017/03/07 [revised]
PHST- 2017/03/08 [accepted]
AID - S0304-4017(17)30104-8 [pii]
AID - 10.1016/j.vetpar.2017.03.010 [doi]
PST - ppublish
SO  - Vet Parasitol. 2017 Apr;238 Suppl 1:S18-S21. doi: 10.1016/j.vetpar.2017.03.010.

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