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Efficacy of a new spot-on formulation of selamectin plus sarolaner for cats against adult Ctenocephalides felis, flea egg production and adult flea emergence.

Abstract A new spot-on formulation of selamectin plus sarolaner was evaluated against fleas for adulticidal efficacy, and for the effect on egg production and hatching when applied to flea-infested cats. Ten male and ten female adult domestic shorthair cats were randomly assigned to one of two treatment groups based on pre-treatment flea counts. Cats received topical treatment on Day 0 in a single spot to the dorsal scapular area with either a placebo formulation or with the combination formulation at the minimal dose of 6.0mg selamectin plus 1.0mg sarolaner per kg bodyweight. On Days -1, 5, 12, 19, 26 and 33, cats were infested with approximately 100 (±5) unfed Ctenocephalides felis fleas. At 24h after treatment or 48h after subsequent flea infestation, cats were housed for a 20-h period in a cage to allow collection of flea eggs. At the end of this period, flea eggs were collected from the cages and cats were combed to remove and count live fleas. Emerged viable larvae and emerged adult fleas were counted 3days and 35days, respectively, after egg collection. The new spot-on formulation of selamectin plus sarolaner provided 100% efficacy against adult fleas up to Day 36 following a single application. Fleas on placebo-treated cats produced large numbers of eggs throughout the study, with individual counts ranging from 110 to 1256 eggs. Following treatment, four flea eggs were collected from a single selamectin/sarolaner-treated cat on Day 29, but there were no eggs collected from any other selamectin/sarolaner-treated animal during the study. No larvae or adult fleas developed from these four eggs. From the eggs collected from the placebo-treated cats, the mean percentage of live larvae and adults that emerged ranged from 67.3% to 84.2% and from 50.7% to 81.8%, respectively. A single topical treatment with a new spot-on formulation of selamectin plus sarolaner at the minimum label dose thus controlled fleas on cats and was 100% effective in preventing flea reproduction for over one month after treatment.
PMID
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Authors

Mayor MeshTerms
Keywords

Cat

Ctenocephalides felis

Flea

Isoxazoline

Larvicide

Ovicide

Reproduction

Sarolaner

Selamectin

Topical

Journal Title veterinary parasitology
Publication Year Start




PMID- 28395752
OWN - NLM
STAT- In-Process
DA  - 20170411
LR  - 20170411
IS  - 1873-2550 (Electronic)
IS  - 0304-4017 (Linking)
VI  - 238 Suppl 1
DP  - 2017 Apr
TI  - Efficacy of a new spot-on formulation of selamectin plus sarolaner for cats
      against adult Ctenocephalides felis, flea egg production and adult flea
      emergence.
PG  - S22-S26
LID - S0304-4017(17)30075-4 [pii]
LID - 10.1016/j.vetpar.2017.02.026 [doi]
AB  - A new spot-on formulation of selamectin plus sarolaner was evaluated against
      fleas for adulticidal efficacy, and for the effect on egg production and hatching
      when applied to flea-infested cats. Ten male and ten female adult domestic
      shorthair cats were randomly assigned to one of two treatment groups based on
      pre-treatment flea counts. Cats received topical treatment on Day 0 in a single
      spot to the dorsal scapular area with either a placebo formulation or with the
      combination formulation at the minimal dose of 6.0mg selamectin plus 1.0mg
      sarolaner per kg bodyweight. On Days -1, 5, 12, 19, 26 and 33, cats were infested
      with approximately 100 (+/-5) unfed Ctenocephalides felis fleas. At 24h after
      treatment or 48h after subsequent flea infestation, cats were housed for a 20-h
      period in a cage to allow collection of flea eggs. At the end of this period,
      flea eggs were collected from the cages and cats were combed to remove and count 
      live fleas. Emerged viable larvae and emerged adult fleas were counted 3days and 
      35days, respectively, after egg collection. The new spot-on formulation of
      selamectin plus sarolaner provided 100% efficacy against adult fleas up to Day 36
      following a single application. Fleas on placebo-treated cats produced large
      numbers of eggs throughout the study, with individual counts ranging from 110 to 
      1256 eggs. Following treatment, four flea eggs were collected from a single
      selamectin/sarolaner-treated cat on Day 29, but there were no eggs collected from
      any other selamectin/sarolaner-treated animal during the study. No larvae or
      adult fleas developed from these four eggs. From the eggs collected from the
      placebo-treated cats, the mean percentage of live larvae and adults that emerged 
      ranged from 67.3% to 84.2% and from 50.7% to 81.8%, respectively. A single
      topical treatment with a new spot-on formulation of selamectin plus sarolaner at 
      the minimum label dose thus controlled fleas on cats and was 100% effective in
      preventing flea reproduction for over one month after treatment.
CI  - Copyright (c) 2017 Zoetis Services LLC. Published by Elsevier B.V. All rights
      reserved.
FAU - Vatta, Adriano F
AU  - Vatta AF
AD  - Zoetis, Veterinary Medicine Research and Development, 333 Portage Street,
      Kalamazoo, MI 49007, USA. Electronic address: [email protected]
FAU - Everett, William R
AU  - Everett WR
AD  - BerTek, Inc., P.O. Box 606, Greenbrier, AR 72058, USA.
FAU - Holzmer, Susan J
AU  - Holzmer SJ
AD  - Zoetis, Veterinary Medicine Research and Development, 333 Portage Street,
      Kalamazoo, MI 49007, USA.
FAU - Cherni, Judith A
AU  - Cherni JA
AD  - Zoetis, Veterinary Medicine Research and Development, 333 Portage Street,
      Kalamazoo, MI 49007, USA.
FAU - King, Vickie L
AU  - King VL
AD  - Zoetis, Veterinary Medicine Research and Development, 333 Portage Street,
      Kalamazoo, MI 49007, USA.
FAU - Rugg, Douglas
AU  - Rugg D
AD  - Zoetis, Veterinary Medicine Research and Development, 333 Portage Street,
      Kalamazoo, MI 49007, USA.
FAU - Geurden, Thomas
AU  - Geurden T
AD  - Zoetis, Veterinary Medicine Research and Development, Hoge Wei 10, B-1930
      Zaventem, Belgium.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Vet Parasitol
JT  - Veterinary parasitology
JID - 7602745
OTO - NOTNLM
OT  - Cat
OT  - Ctenocephalides felis
OT  - Flea
OT  - Isoxazoline
OT  - Larvicide
OT  - Ovicide
OT  - Reproduction
OT  - Sarolaner
OT  - Selamectin
OT  - Topical
EDAT- 2017/04/12 06:00
MHDA- 2017/04/12 06:00
CRDT- 2017/04/12 06:00
PHST- 2016/12/15 [received]
PHST- 2017/02/20 [revised]
PHST- 2017/02/23 [accepted]
AID - S0304-4017(17)30075-4 [pii]
AID - 10.1016/j.vetpar.2017.02.026 [doi]
PST - ppublish
SO  - Vet Parasitol. 2017 Apr;238 Suppl 1:S22-S26. doi: 10.1016/j.vetpar.2017.02.026.

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