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Efficacy of a new spot-on formulation of selamectin plus sarolaner against Ancylostoma tubaeforme and Toxocara cati in cats.

Abstract The efficacy of a new spot-on formulation of selamectin plus sarolaner for cats was evaluated against induced infections with Ancylostoma tubaeforme (hookworm) and Toxocara cati (roundworm). Five laboratory studies were conducted using adult, purpose-bred cats. Four of the studies were designed to evaluate efficacy of the combination against A. tubaeforme, the dose-limiting gastrointestinal nematode species for selamectin. In two of these studies non-interference between selamectin and sarolaner was also evaluated. The fifth study evaluated efficacy of the combination against mixed infections of A. tubaeforme and T. cati. The hookworm isolates in three studies were of US origin, as was the roundworm isolate. In the two remaining studies, cats were inoculated with a hookworm isolate of European origin. Cats were inoculated with 150 (±50) to 200 (±50) infective hookworm larvae 30-42days prior to treatment and with 400 infective roundworm eggs 60days prior to treatment. Cats were ranked by pre-treatment faecal egg counts and randomly allocated to different treatment groups. In all studies, cats were treated at the minimum label dose to provide 6.0mg selamectin per kg bodyweight. All animals were euthanized 7-10days after treatment for worm counts. Efficacy was calculated based on the reduction of the geometric mean worm counts in the treated groups versus the placebo-treated control groups. The efficacy against adult hookworms was 99.2%, 94.3% and 100% in three of these studies, and was lower in the remaining two studies. The efficacy against T. cati was 100%. Furthermore, non-interference between sarolaner and selamectin was demonstrated. Thus, a single topical application of the new spot-on formulation of selamectin plus sarolaner at the minimum label dose is effective in the treatment of adult hookworm and roundworm infections in cats.
PMID
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Authors

Mayor MeshTerms
Keywords

Ancylostoma tubaeforme

Cat

Isoxazoline

Sarolaner

Selamectin

Topical Toxocara cati

Journal Title veterinary parasitology
Publication Year Start




PMID- 28395755
OWN - NLM
STAT- In-Process
DA  - 20170411
LR  - 20170411
IS  - 1873-2550 (Electronic)
IS  - 0304-4017 (Linking)
VI  - 238 Suppl 1
DP  - 2017 Apr
TI  - Efficacy of a new spot-on formulation of selamectin plus sarolaner against
      Ancylostoma tubaeforme and Toxocara cati in cats.
PG  - S31-S35
LID - S0304-4017(17)30077-8 [pii]
LID - 10.1016/j.vetpar.2017.02.027 [doi]
AB  - The efficacy of a new spot-on formulation of selamectin plus sarolaner for cats
      was evaluated against induced infections with Ancylostoma tubaeforme (hookworm)
      and Toxocara cati (roundworm). Five laboratory studies were conducted using
      adult, purpose-bred cats. Four of the studies were designed to evaluate efficacy 
      of the combination against A. tubaeforme, the dose-limiting gastrointestinal
      nematode species for selamectin. In two of these studies non-interference between
      selamectin and sarolaner was also evaluated. The fifth study evaluated efficacy
      of the combination against mixed infections of A. tubaeforme and T. cati. The
      hookworm isolates in three studies were of US origin, as was the roundworm
      isolate. In the two remaining studies, cats were inoculated with a hookworm
      isolate of European origin. Cats were inoculated with 150 (+/-50) to 200 (+/-50) 
      infective hookworm larvae 30-42days prior to treatment and with 400 infective
      roundworm eggs 60days prior to treatment. Cats were ranked by pre-treatment
      faecal egg counts and randomly allocated to different treatment groups. In all
      studies, cats were treated at the minimum label dose to provide 6.0mg selamectin 
      per kg bodyweight. All animals were euthanized 7-10days after treatment for worm 
      counts. Efficacy was calculated based on the reduction of the geometric mean worm
      counts in the treated groups versus the placebo-treated control groups. The
      efficacy against adult hookworms was 99.2%, 94.3% and 100% in three of these
      studies, and was lower in the remaining two studies. The efficacy against T. cati
      was 100%. Furthermore, non-interference between sarolaner and selamectin was
      demonstrated. Thus, a single topical application of the new spot-on formulation
      of selamectin plus sarolaner at the minimum label dose is effective in the
      treatment of adult hookworm and roundworm infections in cats.
CI  - Copyright (c) 2017 Zoetis Services LLC. Published by Elsevier B.V. All rights
      reserved.
FAU - Geurden, Thomas
AU  - Geurden T
AD  - Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20, B-1930 
      Zaventem, Belgium. Electronic address: [email protected]
FAU - Vatta, Adriano F
AU  - Vatta AF
AD  - Zoetis, Veterinary Medicine Research and Development, 333 Portage Street
      Kalamazoo, MI 49007, USA.
FAU - Slootmans, Nathalie
AU  - Slootmans N
AD  - Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20, B-1930 
      Zaventem, Belgium.
FAU - King, Vickie L
AU  - King VL
AD  - Zoetis, Veterinary Medicine Research and Development, 333 Portage Street
      Kalamazoo, MI 49007, USA.
FAU - Lin, Dan
AU  - Lin D
AD  - Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20, B-1930 
      Zaventem, Belgium.
FAU - McTier, Tom
AU  - McTier T
AD  - Zoetis, Veterinary Medicine Research and Development, 333 Portage Street
      Kalamazoo, MI 49007, USA.
FAU - Rugg, Douglas
AU  - Rugg D
AD  - Zoetis, Veterinary Medicine Research and Development, 333 Portage Street
      Kalamazoo, MI 49007, USA.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Vet Parasitol
JT  - Veterinary parasitology
JID - 7602745
OTO - NOTNLM
OT  - Ancylostoma tubaeforme
OT  - Cat
OT  - Isoxazoline
OT  - Sarolaner
OT  - Selamectin
OT  - Topical Toxocara cati
EDAT- 2017/04/12 06:00
MHDA- 2017/04/12 06:00
CRDT- 2017/04/12 06:00
PHST- 2016/12/15 [received]
PHST- 2017/01/30 [revised]
PHST- 2017/02/23 [accepted]
AID - S0304-4017(17)30077-8 [pii]
AID - 10.1016/j.vetpar.2017.02.027 [doi]
PST - ppublish
SO  - Vet Parasitol. 2017 Apr;238 Suppl 1:S31-S35. doi: 10.1016/j.vetpar.2017.02.027.

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