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Speed of kill of a new spot-on formulation of selamectin plus sarolaner for cats against induced infestations with Ixodes ricinus.

Abstract The speed of kill of a new spot-on formulation containing selamectin plus sarolaner (Stronghold(®)Plus, Zoetis) for cats was evaluated against Ixodes ricinus ticks in a placebo-controlled, blinded study. Sixteen (16) cats were blocked by pre-treatment tick counts and randomly allocated to the placebo-treated group or the selamectin/sarolaner-treated group. Cats either received a single topical treatment at the minimum dose of 6.0mg selamectin and 1.0mg sarolaner per kg bodyweight or a placebo formulation on Day 0. On Days -2, 7, 14, 21, 28 and 35, cats were infested with approximately 50 unfed, viable and adult I. ricinus ticks. Tick counts were performed in situ 8 and 12h after treatment or re-infestation. Ticks were removed from the cats and counted at the 24h tick count. Acaricidal efficacy at each time point was calculated based on the reduction of mean live tick counts in the selamectin/sarolaner-treated group versus the placebo-treated group. There were no treatment-related adverse reactions during the study. Placebo-treated cats maintained infestations with mean tick counts ranging from 10.3 to 21.9 throughout the study. The new spot-on formulation of selamectin plus sarolaner demonstrated 99.3% efficacy (P<0.0001) within 24h after treatment against pre-existing infestations. For subsequent re-infestations, efficacy was >97.9% for at least 3 weeks and was 89.0% after the re-infestation on Day 28. Mean live tick counts were significantly reduced by 12h after re-infestation for at least 28 days (P<0.0338). Thus, a single application of the new spot-on formulation of selamectin plus sarolaner at the minimum label dose started killing ticks within 24h after treatment and within 12h after re-infestations for 4 weeks. High acaricidal efficacy was achieved within 24h after treatment and this persisted following subsequent re-infestations for a month.
PMID
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Authors

Mayor MeshTerms
Keywords

Cat

Ixodes ricinus

Sarolaner

Selamectin

Speed of kill

Stronghold

Tick

Journal Title veterinary parasitology
Publication Year Start




PMID- 28395756
OWN - NLM
STAT- MEDLINE
DA  - 20170411
DCOM- 20170418
LR  - 20170418
IS  - 1873-2550 (Electronic)
IS  - 0304-4017 (Linking)
VI  - 238 Suppl 1
DP  - 2017 Apr
TI  - Speed of kill of a new spot-on formulation of selamectin plus sarolaner for cats 
      against induced infestations with Ixodes ricinus.
PG  - S8-S11
LID - S0304-4017(17)30103-6 [pii]
LID - 10.1016/j.vetpar.2017.03.009 [doi]
AB  - The speed of kill of a new spot-on formulation containing selamectin plus
      sarolaner (Stronghold(R)Plus, Zoetis) for cats was evaluated against Ixodes
      ricinus ticks in a placebo-controlled, blinded study. Sixteen (16) cats were
      blocked by pre-treatment tick counts and randomly allocated to the
      placebo-treated group or the selamectin/sarolaner-treated group. Cats either
      received a single topical treatment at the minimum dose of 6.0mg selamectin and
      1.0mg sarolaner per kg bodyweight or a placebo formulation on Day 0. On Days -2, 
      7, 14, 21, 28 and 35, cats were infested with approximately 50 unfed, viable and 
      adult I. ricinus ticks. Tick counts were performed in situ 8 and 12h after
      treatment or re-infestation. Ticks were removed from the cats and counted at the 
      24h tick count. Acaricidal efficacy at each time point was calculated based on
      the reduction of mean live tick counts in the selamectin/sarolaner-treated group 
      versus the placebo-treated group. There were no treatment-related adverse
      reactions during the study. Placebo-treated cats maintained infestations with
      mean tick counts ranging from 10.3 to 21.9 throughout the study. The new spot-on 
      formulation of selamectin plus sarolaner demonstrated 99.3% efficacy (P&lt;0.0001)
      within 24h after treatment against pre-existing infestations. For subsequent
      re-infestations, efficacy was &gt;97.9% for at least 3 weeks and was 89.0% after the
      re-infestation on Day 28. Mean live tick counts were significantly reduced by 12h
      after re-infestation for at least 28 days (P&lt;0.0338). Thus, a single application 
      of the new spot-on formulation of selamectin plus sarolaner at the minimum label 
      dose started killing ticks within 24h after treatment and within 12h after
      re-infestations for 4 weeks. High acaricidal efficacy was achieved within 24h
      after treatment and this persisted following subsequent re-infestations for a
      month.
CI  - Copyright (c) 2017 Zoetis Services LLC. Published by Elsevier B.V. All rights
      reserved.
FAU - Becskei, Csilla
AU  - Becskei C
AD  - Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20,
      Zaventem B-1930, Belgium. Electronic address: [email protected]
FAU - Lin, Dan
AU  - Lin D
AD  - Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20,
      Zaventem B-1930, Belgium.
FAU - Rugg, Douglas
AU  - Rugg D
AD  - Zoetis, Veterinary Medicine Research and Development, 333 Portage Street,
      Kalamazoo, MI 49007, USA.
FAU - Geurden, Thomas
AU  - Geurden T
AD  - Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20,
      Zaventem B-1930, Belgium.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Vet Parasitol
JT  - Veterinary parasitology
JID - 7602745
RN  - 0 (Antiparasitic Agents)
RN  - 0 (Isoxazoles)
RN  - 70288-86-7 (Ivermectin)
RN  - A2669OWX9N (selamectin)
SB  - IM
MH  - Administration, Topical
MH  - Animals
MH  - Antiparasitic Agents/administration &amp; dosage
MH  - Cat Diseases/*drug therapy
MH  - Cats
MH  - Female
MH  - Isoxazoles/*administration &amp; dosage
MH  - Ivermectin/administration &amp; dosage/*analogs &amp; derivatives
MH  - Male
MH  - Random Allocation
MH  - Tick Infestations/drug therapy/*veterinary
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Cat
OT  - Ixodes ricinus
OT  - Sarolaner
OT  - Selamectin
OT  - Speed of kill
OT  - Stronghold
OT  - Tick
EDAT- 2017/04/12 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/12 06:00
PHST- 2016/12/15 [received]
PHST- 2017/03/07 [revised]
PHST- 2017/03/08 [accepted]
AID - S0304-4017(17)30103-6 [pii]
AID - 10.1016/j.vetpar.2017.03.009 [doi]
PST - ppublish
SO  - Vet Parasitol. 2017 Apr;238 Suppl 1:S8-S11. doi: 10.1016/j.vetpar.2017.03.009.

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