PubTransformer

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PMID- 28397557
OWN - NLM
STAT- MEDLINE
DA  - 20170411
DCOM- 20170418
LR  - 20170418
IS  - 1943-572X (Electronic)
IS  - 0003-4894 (Linking)
VI  - 126
IP  - 5
DP  - 2017 May
TI  - Factors Associated With Infectious Laryngitis: A Retrospective Review of 15
      Cases.
PG  - 388-395
LID - 10.1177/0003489417694911 [doi]
AB  - OBJECTIVES: To identify the culturable microbes associated with infectious
      laryngitis and outline effective treatment strategies. METHODS: This is a
      retrospective chart review of adult patients with persistent dysphonia plus
      evidence of laryngeal inflammation who underwent biopsy for culture at a tertiary
      care medical center. Demographic factors, symptoms as reported on validated
      patient assessment tools, past medical history, social history, culture results, 
      and treatment duration and response were reviewed. RESULTS: Fifteen patients with
      infectious laryngitis were included in this study. Culture results demonstrated
      Methicillin-sensitive Staphylococcus aureus (MSSA), Methicillin-resistant
      Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Serratia marcescens, and
      "normal respiratory flora." In most patients, multiple courses of prolonged
      antibiotics were needed to treat MSSA or MRSA. Infections associated with other
      microbes resolved with a single course of antibiotics. CONCLUSIONS: In this
      population, infectious laryngitis is defined as colonization with bacteria not
      found in the previously characterized laryngeal microbiome of benign vocal fold
      lesions. In suspected cases of infectious laryngitis, culture is recommended, by 
      biopsy if needed. For MSSA- and MRSA-associated laryngitis, an extended course of
      antibiotics may be necessary for symptom improvement and resolution of laryngeal 
      inflammation. However, the optimal treatment regimen has yet to be defined and
      will require larger, prospective studies.
FAU - Thomas, Carissa M
AU  - Thomas CM
AD  - 1 Department of Otolaryngology-Head and Neck Surgery, University of Colorado
      School of Medicine, Aurora, CO, USA.
FAU - Jette, Marie E
AU  - Jette ME
AD  - 1 Department of Otolaryngology-Head and Neck Surgery, University of Colorado
      School of Medicine, Aurora, CO, USA.
FAU - Clary, Matthew S
AU  - Clary MS
AD  - 1 Department of Otolaryngology-Head and Neck Surgery, University of Colorado
      School of Medicine, Aurora, CO, USA.
LA  - eng
PT  - Journal Article
DEP - 20170201
PL  - United States
TA  - Ann Otol Rhinol Laryngol
JT  - The Annals of otology, rhinology, and laryngology
JID - 0407300
RN  - 0 (Anti-Bacterial Agents)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - *Bacteria/classification/drug effects/isolation & purification/pathogenicity
MH  - Biopsy/methods
MH  - Drug Resistance, Bacterial
MH  - Female
MH  - Humans
MH  - Inflammation/microbiology/physiopathology
MH  - *Laryngitis/diagnosis/drug therapy/microbiology/physiopathology
MH  - Male
MH  - Microbial Sensitivity Tests/methods/statistics & numerical data
MH  - Middle Aged
MH  - Retrospective Studies
MH  - United States
OTO - NOTNLM
OT  - Staphylococcus aureus
OT  - bacteria
OT  - chronic laryngitis
OT  - infectious laryngitis
OT  - inflammation
OT  - laryngitis
EDAT- 2017/04/12 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/12 06:00
AID - 10.1177/0003489417694911 [doi]
PST - ppublish
SO  - Ann Otol Rhinol Laryngol. 2017 May;126(5):388-395. doi: 10.1177/0003489417694911.
      Epub 2017 Feb 1.

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