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Pathologic Markers in Surgically Treated HPV-Associated Oropharyngeal Cancer: Retrospective Study, Systematic Review, and Meta-analysis.

Abstract Human papillomavirus-associated (HPV) oropharyngeal cancer is a unique clinical entity whose incidence is increasing. It is controversial whether traditional pathologic markers of aggressive head and neck cancer also apply in surgically treated HPV-associated disease.
PMID
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Authors

Mayor MeshTerms

Oropharyngeal Neoplasms

Otorhinolaryngologic Surgical Procedures

Papillomavirus Infections

Keywords

HPV

human papillomavirus

oropharyngeal cancer

pathologic markers

Journal Title the annals of otology, rhinology, and laryngology
Publication Year Start




PMID- 28397563
OWN - NLM
STAT- MEDLINE
DA  - 20170411
DCOM- 20170418
LR  - 20170418
IS  - 1943-572X (Electronic)
IS  - 0003-4894 (Linking)
VI  - 126
IP  - 5
DP  - 2017 May
TI  - Pathologic Markers in Surgically Treated HPV-Associated Oropharyngeal Cancer:
      Retrospective Study, Systematic Review, and Meta-analysis.
PG  - 365-374
LID - 10.1177/0003489417693014 [doi]
AB  - OBJECTIVE: Human papillomavirus-associated (HPV) oropharyngeal cancer is a unique
      clinical entity whose incidence is increasing. It is controversial whether
      traditional pathologic markers of aggressive head and neck cancer also apply in
      surgically treated HPV-associated disease. STUDY DESIGN: Retrospective study,
      systematic review, and meta-analysis Data Sources: PubMed and Cochrane review.
      REVIEW METHODS: PubMed and Cochrane review were searched for published articles
      on surgically treated HPV-associated oropharyngeal cancer. Eligible studies were 
      included in a meta-analysis of survival using several clinicopathologic markers
      as predictors. Surgically treated HPV-positive oropharyngeal cancer patients at
      our institution were studied retrospectively and added to the meta-analysis.
      RESULTS: Eight published reports, plus our retrospective series, were included in
      the meta-analysis. This showed significant impact on event-free survival for T
      stage, nodal number, perineural invasion, and lymphovascular invasion (all P <
      .05) but not for N stage extracapsular extension ( P = ns). CONCLUSIONS: While
      many traditional clinico-pathologic markers of aggressive disease in head and
      neck cancer also impact survival in surgically treated HPV-associated
      oropharyngeal cancer, extracapsular extension may be less important.
FAU - Tassone, Patrick
AU  - Tassone P
AD  - 1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson
      University, Philadelphia, Pennsylvania, USA.
FAU - Crawley, Meghan
AU  - Crawley M
AD  - 1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson
      University, Philadelphia, Pennsylvania, USA.
FAU - Bovenzi, Cory
AU  - Bovenzi C
AD  - 1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson
      University, Philadelphia, Pennsylvania, USA.
FAU - Zhan, Tingting
AU  - Zhan T
AD  - 2 Department of Biostatistics, Thomas Jefferson University, Philadelphia,
      Pennsylvania, USA.
FAU - Keane, William
AU  - Keane W
AD  - 1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson
      University, Philadelphia, Pennsylvania, USA.
FAU - Cognetti, David
AU  - Cognetti D
AD  - 1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson
      University, Philadelphia, Pennsylvania, USA.
FAU - Luginbuhl, Adam
AU  - Luginbuhl A
AD  - 1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson
      University, Philadelphia, Pennsylvania, USA.
FAU - Curry, Joseph
AU  - Curry J
AD  - 1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson
      University, Philadelphia, Pennsylvania, USA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20170216
PL  - United States
TA  - Ann Otol Rhinol Laryngol
JT  - The Annals of otology, rhinology, and laryngology
JID - 0407300
SB  - AIM
SB  - IM
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - *Oropharyngeal Neoplasms/complications/pathology/surgery
MH  - *Otorhinolaryngologic Surgical Procedures/methods/statistics & numerical data
MH  - Papillomaviridae/*isolation & purification
MH  - *Papillomavirus Infections/complications
MH  - Prognosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - *HPV
OT  - *human papillomavirus
OT  - *oropharyngeal cancer
OT  - *pathologic markers
EDAT- 2017/04/12 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/12 06:00
AID - 10.1177/0003489417693014 [doi]
PST - ppublish
SO  - Ann Otol Rhinol Laryngol. 2017 May;126(5):365-374. doi: 10.1177/0003489417693014.
      Epub 2017 Feb 16.

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