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Local Intraluminal Irrigation With Argatroban During Free Flap Repair in a Patient With Heparin-Induced Thrombocytopenia.

Abstract This study describes a case of a successful free flap repair using argatroban for local intraluminal irrigation as a substitute to heparin in a patient with heparin-induced thrombocytopenia.
PMID
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Authors

Mayor MeshTerms

Carcinoma, Squamous Cell

Head and Neck Neoplasms

Mouth Neoplasms

Keywords

argatroban

free flap reconstruction

head and neck cancer

head and neck reconstruction

head and neck surgery

heparin-induced thrombocytopenia

microsurgery

radial forearm free flap

Journal Title the annals of otology, rhinology, and laryngology
Publication Year Start




PMID- 28397565
OWN - NLM
STAT- MEDLINE
DA  - 20170411
DCOM- 20170418
LR  - 20170418
IS  - 1943-572X (Electronic)
IS  - 0003-4894 (Linking)
VI  - 126
IP  - 5
DP  - 2017 May
TI  - Local Intraluminal Irrigation With Argatroban During Free Flap Repair in a
      Patient With Heparin-Induced Thrombocytopenia.
PG  - 407-410
LID - 10.1177/0003489417693015 [doi]
AB  - OBJECTIVE: This study describes a case of a successful free flap repair using
      argatroban for local intraluminal irrigation as a substitute to heparin in a
      patient with heparin-induced thrombocytopenia. METHODS: Case report and review of
      literature. RESULTS: The patient had an uneventful postoperative course, and the 
      free flap survived without complications. CONCLUSIONS: The use of argatroban
      during microvascular surgery is likely to be safe and simple and may be effective
      in preventing micro-thrombotic complications during microvascular surgery, and it
      should be considered as an alternative to heparinized saline for local
      intraluminal irrigation.
FAU - Macias, David
AU  - Macias D
AD  - 1 Loma Linda University School of Medicine, Loma Linda, California, USA.
FAU - Kwon, Daniel I
AU  - Kwon DI
AD  - 2 Loma Linda University Medical Center, Department of Otolaryngology, Head & Neck
      Surgery & Facial Plastic Surgery, Loma Linda, California, USA.
FAU - Walker, Paul C
AU  - Walker PC
AD  - 2 Loma Linda University Medical Center, Department of Otolaryngology, Head & Neck
      Surgery & Facial Plastic Surgery, Loma Linda, California, USA.
FAU - Peterson, Nathaniel R
AU  - Peterson NR
AD  - 2 Loma Linda University Medical Center, Department of Otolaryngology, Head & Neck
      Surgery & Facial Plastic Surgery, Loma Linda, California, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170301
PL  - United States
TA  - Ann Otol Rhinol Laryngol
JT  - The Annals of otology, rhinology, and laryngology
JID - 0407300
RN  - 0 (Pipecolic Acids)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - IY90U61Z3S (argatroban)
SB  - AIM
SB  - IM
MH  - *Carcinoma, Squamous Cell/pathology/surgery
MH  - Female
MH  - Forearm/surgery
MH  - Free Tissue Flaps/blood supply
MH  - *Head and Neck Neoplasms/pathology/surgery
MH  - Humans
MH  - Middle Aged
MH  - *Mouth Neoplasms/pathology/surgery
MH  - Neck Dissection/*methods
MH  - Pipecolic Acids/*administration & dosage
MH  - Platelet Aggregation Inhibitors/administration & dosage
MH  - Radial Artery/surgery
MH  - Treatment Outcome
OTO - NOTNLM
OT  - *argatroban
OT  - *free flap reconstruction
OT  - *head and neck cancer
OT  - *head and neck reconstruction
OT  - *head and neck surgery
OT  - *heparin-induced thrombocytopenia
OT  - *microsurgery
OT  - *radial forearm free flap
EDAT- 2017/04/12 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/12 06:00
AID - 10.1177/0003489417693015 [doi]
PST - ppublish
SO  - Ann Otol Rhinol Laryngol. 2017 May;126(5):407-410. doi: 10.1177/0003489417693015.
      Epub 2017 Mar 1.

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