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Framingham Risk Score as a Prognostic Predictor of Sudden Sensorineural Hearing Loss: A Preliminary Study.

Abstract Predicting the prognosis of idiopathic sudden sensorineural hearing loss (ISSHL) remains challenging. This investigation aimed to apply Framingham Risk Scores (FRS) to assess the combination of prognostic factors following ISSHL and investigate the predictive role of FRS in patients with multiple comorbidities including hypertension, diabetes, and hyperlipidemia.
PMID
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Authors

Mayor MeshTerms

Hearing Loss, Sensorineural

Keywords

Framingham risk score

Siegel’s criteria

corticosteroid

idiopathic sudden sensorineural hearing loss

pure tone audiometry

Journal Title the annals of otology, rhinology, and laryngology
Publication Year Start




PMID- 28397567
OWN - NLM
STAT- MEDLINE
DA  - 20170411
DCOM- 20170418
LR  - 20170418
IS  - 1943-572X (Electronic)
IS  - 0003-4894 (Linking)
VI  - 126
IP  - 5
DP  - 2017 May
TI  - Framingham Risk Score as a Prognostic Predictor of Sudden Sensorineural Hearing
      Loss: A Preliminary Study.
PG  - 382-387
LID - 10.1177/0003489417694910 [doi]
AB  - OBJECTIVES/HYPOTHESIS: Predicting the prognosis of idiopathic sudden
      sensorineural hearing loss (ISSHL) remains challenging. This investigation aimed 
      to apply Framingham Risk Scores (FRS) to assess the combination of prognostic
      factors following ISSHL and investigate the predictive role of FRS in patients
      with multiple comorbidities including hypertension, diabetes, and hyperlipidemia.
      STUDY DESIGN: Retrospective study. METHODS: Twenty-one patients presenting with
      unilateral idiopathic sudden sensorineural hearing loss and multiple
      comorbidities were surveyed. Framingham Risk Score was calculated, and patients
      were assigned into high-risk (FRS >/=20%) and low-risk (FRS <20%) groups. Mean
      pure tone audiometry (PTA) threshold of both groups and hearing outcomes
      following established criteria were investigated. All patients were treated with 
      the same protocol of oral methylprednisolone. RESULTS: Overall successful
      recovery rate (complete + marked recovery) was 23.81%. The mean PTA threshold of 
      the low-risk group showed significant improvement (mean PTA +/- standard error,
      SE: pretreatment, 73.23 +/- 11.80; posttreatment, 54.89 +/- 10.25, P = .002),
      while the high-risk group did not show significant improvement in mean PTA
      threshold (mean PTA +/- SE: pretreatment, 71.94 +/- 11.77; posttreatment, 68.89
      +/- 12.81, P = .73). CONCLUSION: Framingham Risk Scores may be useful in
      predicting outcomes for ISSHL patients with multiple comorbidities.
FAU - Chang, Young-Soo
AU  - Chang YS
AD  - 1 Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical
      Center, Sunkyunkwan University School of Medicine, Seoul, Korea.
FAU - Choi, Ji Eun
AU  - Choi JE
AD  - 1 Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical
      Center, Sunkyunkwan University School of Medicine, Seoul, Korea.
FAU - Ahn, Jungmin
AU  - Ahn J
AD  - 1 Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical
      Center, Sunkyunkwan University School of Medicine, Seoul, Korea.
FAU - Ryu, Nam-Gyu
AU  - Ryu NG
AD  - 2 Department of Otorhinolaryngology, Inje University College of Medicine,
      Republic of Korea.
FAU - Moon, Il Joon
AU  - Moon IJ
AD  - 1 Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical
      Center, Sunkyunkwan University School of Medicine, Seoul, Korea.
FAU - Hong, Sung Hwa
AU  - Hong SH
AD  - 1 Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical
      Center, Sunkyunkwan University School of Medicine, Seoul, Korea.
FAU - Cho, Yang-Sun
AU  - Cho YS
AD  - 1 Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical
      Center, Sunkyunkwan University School of Medicine, Seoul, Korea.
FAU - Chung, Won-Ho
AU  - Chung WH
AD  - 1 Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical
      Center, Sunkyunkwan University School of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20170201
PL  - United States
TA  - Ann Otol Rhinol Laryngol
JT  - The Annals of otology, rhinology, and laryngology
JID - 0407300
RN  - 0 (Glucocorticoids)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - AIM
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Audiometry, Pure-Tone/methods
MH  - Comorbidity
MH  - Female
MH  - Glucocorticoids/administration & dosage
MH  - *Hearing Loss, Sensorineural/diagnosis/drug therapy/epidemiology
MH  - Hearing Loss, Sudden/diagnosis/drug therapy/epidemiology
MH  - Humans
MH  - Male
MH  - Methylprednisolone/*administration & dosage
MH  - Middle Aged
MH  - Prognosis
MH  - Republic of Korea
MH  - Risk Assessment/methods
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Framingham risk score
OT  - Siegel's criteria
OT  - corticosteroid
OT  - idiopathic sudden sensorineural hearing loss
OT  - pure tone audiometry
EDAT- 2017/04/12 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/12 06:00
AID - 10.1177/0003489417694910 [doi]
PST - ppublish
SO  - Ann Otol Rhinol Laryngol. 2017 May;126(5):382-387. doi: 10.1177/0003489417694910.
      Epub 2017 Feb 1.

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