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Pathogenicity and transmission of a swine influenza A(H6N6) virus.

Abstract Subtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern China, and since then, it has caused sporadic infections among swine. We show that this virus binds to α2,6-linked and α2,3-linked sialic acids. Mutations at residues 222 (alanine to valine) and 228 (glycine to serine) of the virus hemagglutinin (HA) affected its receptor-binding properties. Experiments showed that the virus has limited transmissibility between ferrets through direct contact or through inhalation of infectious aerosolized droplets. The internal genes of the influenza A(H1N1)pdm09 virus, which is prevalent in swine worldwide, increases the replication efficiency of H6N6 IAV in the lower respiratory tract of ferrets but not its transmissibility between ferrets. These findings suggest H6N6 swine IAV (SIV) currently poses a moderate risk to public health, but its evolution and spread should be closely monitored.
PMID
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Authors

Mayor MeshTerms

Virus Attachment

Keywords
Journal Title emerging microbes & infections
Publication Year Start




PMID- 28400591
OWN - NLM
STAT- MEDLINE
DA  - 20170412
DCOM- 20170417
LR  - 20170421
IS  - 2222-1751 (Electronic)
IS  - 2222-1751 (Linking)
VI  - 6
IP  - 4
DP  - 2017 Apr 12
TI  - Pathogenicity and transmission of a swine influenza A(H6N6) virus.
PG  - e17
LID - 10.1038/emi.2017.3 [doi]
AB  - Subtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and
      domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern
      China, and since then, it has caused sporadic infections among swine. We show
      that this virus binds to alpha2,6-linked and alpha2,3-linked sialic acids.
      Mutations at residues 222 (alanine to valine) and 228 (glycine to serine) of the 
      virus hemagglutinin (HA) affected its receptor-binding properties. Experiments
      showed that the virus has limited transmissibility between ferrets through direct
      contact or through inhalation of infectious aerosolized droplets. The internal
      genes of the influenza A(H1N1)pdm09 virus, which is prevalent in swine worldwide,
      increases the replication efficiency of H6N6 IAV in the lower respiratory tract
      of ferrets but not its transmissibility between ferrets. These findings suggest
      H6N6 swine IAV (SIV) currently poses a moderate risk to public health, but its
      evolution and spread should be closely monitored.
FAU - Sun, Hailiang
AU  - Sun H
AD  - Department of Basic Sciences, College of Veterinary Medicine, Mississippi State
      University, Mississippi State, MS 39759, USA.
FAU - Kaplan, Bryan S
AU  - Kaplan BS
AD  - Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis,
      TN 38105, USA.
FAU - Guan, Minhui
AU  - Guan M
AD  - Department of Basic Sciences, College of Veterinary Medicine, Mississippi State
      University, Mississippi State, MS 39759, USA.
FAU - Zhang, Guihong
AU  - Zhang G
AD  - College of Veterinary Medicine, South China Agricultural University, Guangzhou
      510462, Guangdong, China.
FAU - Ye, Jianqiang
AU  - Ye J
AD  - Department of Basic Sciences, College of Veterinary Medicine, Mississippi State
      University, Mississippi State, MS 39759, USA.
FAU - Long, Li-Ping
AU  - Long LP
AD  - Department of Basic Sciences, College of Veterinary Medicine, Mississippi State
      University, Mississippi State, MS 39759, USA.
FAU - Blackmon, Sherry
AU  - Blackmon S
AD  - Department of Basic Sciences, College of Veterinary Medicine, Mississippi State
      University, Mississippi State, MS 39759, USA.
FAU - Yang, Chun-Kai
AU  - Yang CK
AD  - Department of Basic Sciences, College of Veterinary Medicine, Mississippi State
      University, Mississippi State, MS 39759, USA.
FAU - Chiang, Meng-Jung
AU  - Chiang MJ
AD  - Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of
      Vaccines Research and Review, Center for Biologics Evaluation and Research,
      United States Food and Drug Administration, Silver Spring, MD 20993, USA.
FAU - Xie, Hang
AU  - Xie H
AD  - Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of
      Vaccines Research and Review, Center for Biologics Evaluation and Research,
      United States Food and Drug Administration, Silver Spring, MD 20993, USA.
FAU - Zhao, Nan
AU  - Zhao N
AD  - Department of Basic Sciences, College of Veterinary Medicine, Mississippi State
      University, Mississippi State, MS 39759, USA.
FAU - Cooley, Jim
AU  - Cooley J
AD  - Department of Population Medicine and Pathobiology, College of Veterinary
      Medicine, Mississippi State University, Mississippi State, MS 39759, USA.
FAU - Smith, David F
AU  - Smith DF
AD  - Department of Biochemistry, Glycomics Center, School of Medicine, Emory
      University, Atlanta 30322, GA, USA.
FAU - Liao, Ming
AU  - Liao M
AD  - College of Veterinary Medicine, South China Agricultural University, Guangzhou
      510462, Guangdong, China.
FAU - Cardona, Carol
AU  - Cardona C
AD  - College of Veterinary Medicine, University of Minnesota, St Paul, MN 30322, USA.
FAU - Li, Lei
AU  - Li L
AD  - Department of Chemistry, Georgia State University, Atlanta, GA 30302, USA.
FAU - Wang, George Peng
AU  - Wang GP
AD  - Department of Chemistry, Georgia State University, Atlanta, GA 30302, USA.
FAU - Webby, Richard
AU  - Webby R
AD  - Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis,
      TN 38105, USA.
FAU - Wan, Xiu-Feng
AU  - Wan XF
AD  - Department of Basic Sciences, College of Veterinary Medicine, Mississippi State
      University, Mississippi State, MS 39759, USA.
LA  - eng
GR  - P20 GM103646/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20170412
PL  - United States
TA  - Emerg Microbes Infect
JT  - Emerging microbes & infections
JID - 101594885
RN  - 0 (Hemagglutinin Glycoproteins, Influenza Virus)
RN  - 0 (Receptors, Virus)
RN  - 0 (Sialic Acids)
SB  - IM
MH  - Animals
MH  - China
MH  - Hemagglutinin Glycoproteins, Influenza Virus/genetics/metabolism
MH  - Influenza A virus/*isolation & purification/pathogenicity/*physiology
MH  - Mutation, Missense
MH  - Orthomyxoviridae Infections/transmission/*veterinary/virology
MH  - Protein Binding
MH  - Receptors, Virus/metabolism
MH  - Sialic Acids/*metabolism
MH  - Swine
MH  - Swine Diseases/*transmission/*virology
MH  - *Virus Attachment
EDAT- 2017/04/13 06:00
MHDA- 2017/04/18 06:00
CRDT- 2017/04/13 06:00
PHST- 2016/10/18 [received]
PHST- 2016/12/15 [revised]
PHST- 2016/12/29 [accepted]
AID - emi20173 [pii]
AID - 10.1038/emi.2017.3 [doi]
PST - epublish
SO  - Emerg Microbes Infect. 2017 Apr 12;6(4):e17. doi: 10.1038/emi.2017.3.

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