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Rickettsial seropositivity in the indigenous community and animal farm workers, and vector surveillance in Peninsular Malaysia.

Abstract Rickettsioses are emerging zoonotic diseases that are often neglected in many countries in Southeast Asia. Rickettsial agents are transmitted to humans through exposure to infected arthropods. Limited data are available on the exposure of indigenous community and animal farm workers to the aetiological agents and arthropod vectors of rickettsioses in Peninsular Malaysia. Serological analysis of Rickettsia conorii and Rickettsia felis was performed for 102 individuals from the indigenous community at six rural villages and 87 workers from eight animal farms in Peninsular Malaysia in a cross-sectional study. The indigenous community had significantly higher seropositivity rates for R. conorii (P<0.001) and R. felis (P<0.001), as compared to blood donors from urban (n=61). Similarly, higher seropositivity rates for R. conorii (P=0.046) and R. felis (P<0.001) were noted for animal farm workers, as compared to urban blood donors. On the basis of the sequence analysis of gltA, ompA and ompB, various spotted fever group rickettsiae closely related to R. raoultii, R. heilongjiangensis, R. felis-like organisms, R. tamurae, Rickettsia sp. TCM1, R. felis, Rickettsia sp. LON13 and R. hulinensis were identified from tick/flea samples in animal farms, indigenous villages and urban areas. This study describes rickettsial seropositivity of the Malaysian indigenous community and animal farm workers, and provides molecular evidence regarding the presence of rickettsial agents in ticks/fleas infesting domestic animals in Peninsular Malaysia.
PMID
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Authors

Mayor MeshTerms

Farmers

Population Groups

Keywords
Journal Title emerging microbes & infections
Publication Year Start




PMID- 28400593
OWN - NLM
STAT- MEDLINE
DA  - 20170412
DCOM- 20170417
LR  - 20170417
IS  - 2222-1751 (Electronic)
IS  - 2222-1751 (Linking)
VI  - 6
IP  - 4
DP  - 2017 Apr 12
TI  - Rickettsial seropositivity in the indigenous community and animal farm workers,
      and vector surveillance in Peninsular Malaysia.
PG  - e18
LID - 10.1038/emi.2017.4 [doi]
AB  - Rickettsioses are emerging zoonotic diseases that are often neglected in many
      countries in Southeast Asia. Rickettsial agents are transmitted to humans through
      exposure to infected arthropods. Limited data are available on the exposure of
      indigenous community and animal farm workers to the aetiological agents and
      arthropod vectors of rickettsioses in Peninsular Malaysia. Serological analysis
      of Rickettsia conorii and Rickettsia felis was performed for 102 individuals from
      the indigenous community at six rural villages and 87 workers from eight animal
      farms in Peninsular Malaysia in a cross-sectional study. The indigenous community
      had significantly higher seropositivity rates for R. conorii (P&lt;0.001) and R.
      felis (P&lt;0.001), as compared to blood donors from urban (n=61). Similarly, higher
      seropositivity rates for R. conorii (P=0.046) and R. felis (P&lt;0.001) were noted
      for animal farm workers, as compared to urban blood donors. On the basis of the
      sequence analysis of gltA, ompA and ompB, various spotted fever group rickettsiae
      closely related to R. raoultii, R. heilongjiangensis, R. felis-like organisms, R.
      tamurae, Rickettsia sp. TCM1, R. felis, Rickettsia sp. LON13 and R. hulinensis
      were identified from tick/flea samples in animal farms, indigenous villages and
      urban areas. This study describes rickettsial seropositivity of the Malaysian
      indigenous community and animal farm workers, and provides molecular evidence
      regarding the presence of rickettsial agents in ticks/fleas infesting domestic
      animals in Peninsular Malaysia.
FAU - Kho, Kai Ling
AU  - Kho KL
AD  - Department of Medical Microbiology, Faculty of Medicine, University of Malaya,
      50603 Kuala Lumpur, Malaysia.
FAU - Koh, Fui Xian
AU  - Koh FX
AD  - Department of Medical Microbiology, Faculty of Medicine, University of Malaya,
      50603 Kuala Lumpur, Malaysia.
FAU - Hasan, Lailatul Insyirah Mohd
AU  - Hasan LI
AD  - Department of Medical Microbiology, Faculty of Medicine, University of Malaya,
      50603 Kuala Lumpur, Malaysia.
FAU - Wong, Li Ping
AU  - Wong LP
AD  - Julius Centre University of Malaya, Department of Social and Preventive Medicine,
      Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
FAU - Kisomi, Masoumeh Ghane
AU  - Kisomi MG
AD  - Julius Centre University of Malaya, Department of Social and Preventive Medicine,
      Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
FAU - Bulgiba, Awang
AU  - Bulgiba A
AD  - Julius Centre University of Malaya, Department of Social and Preventive Medicine,
      Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
FAU - Nizam, Quaza Nizamuddin Hassan
AU  - Nizam QN
AD  - Department of Veterinary Services, Ministry of Agriculture and Agro-Based
      Industry Malaysia, Federal Government Administrative Centre, 62630 Putrajaya,
      Malaysia.
FAU - Tay, Sun Tee
AU  - Tay ST
AD  - Department of Medical Microbiology, Faculty of Medicine, University of Malaya,
      50603 Kuala Lumpur, Malaysia.
LA  - eng
PT  - Journal Article
DEP - 20170412
PL  - United States
TA  - Emerg Microbes Infect
JT  - Emerging microbes &amp; infections
JID - 101594885
RN  - 0 (Antibodies, Bacterial)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Antibodies, Bacterial/*blood
MH  - Arthropod Vectors/*microbiology
MH  - Child
MH  - Cross-Sectional Studies
MH  - Epidemiological Monitoring
MH  - *Farmers
MH  - Female
MH  - Humans
MH  - Malaysia/epidemiology
MH  - Male
MH  - Middle Aged
MH  - *Population Groups
MH  - Rickettsia conorii/*immunology
MH  - Rickettsia felis/*immunology
MH  - Rickettsiaceae Infections/*epidemiology
MH  - Seroepidemiologic Studies
MH  - Siphonaptera
MH  - Ticks
MH  - Young Adult
EDAT- 2017/04/13 06:00
MHDA- 2017/04/18 06:00
CRDT- 2017/04/13 06:00
PHST- 2016/08/10 [received]
PHST- 2016/11/13 [revised]
PHST- 2016/11/21 [accepted]
AID - emi20174 [pii]
AID - 10.1038/emi.2017.4 [doi]
PST - epublish
SO  - Emerg Microbes Infect. 2017 Apr 12;6(4):e18. doi: 10.1038/emi.2017.4.

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