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Histo-blood group antigens as receptors for rotavirus, new understanding on rotavirus epidemiology and vaccine strategy.

Abstract The success of the two rotavirus (RV) vaccines (Rotarix and RotaTeq) in many countries endorses a live attenuated vaccine approach against RVs. However, the lower efficacies of both vaccines in many low- and middle-income countries indicate a need to improve the current RV vaccines. The recent discovery that RVs recognize histo-blood group antigens (HBGAs) as potential receptors has significantly advanced our understanding of RV diversity, evolution and epidemiology, providing important new insights into the performances of current RV vaccines in different populations and emphasizing a P-type-based vaccine approach. New understanding of RV diversity and evolution also raises a fundamental question about the 'Jennerian' approach, which needs to be addressed for future development of live attenuated RV vaccines. Alternative approaches to develop safer and more cost-effective subunit vaccines against RVs are also discussed.
PMID
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Authors

Mayor MeshTerms

Virus Attachment

Keywords
Journal Title emerging microbes & infections
Publication Year Start




PMID- 28400594
OWN - NLM
STAT- MEDLINE
DA  - 20170412
DCOM- 20170417
LR  - 20170417
IS  - 2222-1751 (Electronic)
IS  - 2222-1751 (Linking)
VI  - 6
IP  - 4
DP  - 2017 Apr 12
TI  - Histo-blood group antigens as receptors for rotavirus, new understanding on
      rotavirus epidemiology and vaccine strategy.
PG  - e22
LID - 10.1038/emi.2017.30 [doi]
AB  - The success of the two rotavirus (RV) vaccines (Rotarix and RotaTeq) in many
      countries endorses a live attenuated vaccine approach against RVs. However, the
      lower efficacies of both vaccines in many low- and middle-income countries
      indicate a need to improve the current RV vaccines. The recent discovery that RVs
      recognize histo-blood group antigens (HBGAs) as potential receptors has
      significantly advanced our understanding of RV diversity, evolution and
      epidemiology, providing important new insights into the performances of current
      RV vaccines in different populations and emphasizing a P-type-based vaccine
      approach. New understanding of RV diversity and evolution also raises a
      fundamental question about the 'Jennerian' approach, which needs to be addressed 
      for future development of live attenuated RV vaccines. Alternative approaches to 
      develop safer and more cost-effective subunit vaccines against RVs are also
      discussed.
FAU - Jiang, Xi
AU  - Jiang X
AD  - Cincinnati Children's Hospital Medical Center, Department of Pediatrics,
      University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
FAU - Liu, Yang
AU  - Liu Y
AD  - Cincinnati Children's Hospital Medical Center, Department of Pediatrics,
      University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
FAU - Tan, Ming
AU  - Tan M
AD  - Cincinnati Children's Hospital Medical Center, Department of Pediatrics,
      University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170412
PL  - United States
TA  - Emerg Microbes Infect
JT  - Emerging microbes & infections
JID - 101594885
RN  - 0 (Blood Group Antigens)
RN  - 0 (Receptors, Virus)
RN  - 0 (Rotavirus Vaccines)
SB  - IM
MH  - Blood Group Antigens/*metabolism
MH  - Drug Discovery/trends
MH  - Humans
MH  - Receptors, Virus/*metabolism
MH  - Rotavirus/immunology/*physiology
MH  - Rotavirus Infections/*epidemiology/*prevention & control
MH  - Rotavirus Vaccines/*immunology/isolation & purification
MH  - *Virus Attachment
EDAT- 2017/04/13 06:00
MHDA- 2017/04/18 06:00
CRDT- 2017/04/13 06:00
PHST- 2017/01/13 [received]
PHST- 2017/03/16 [revised]
PHST- 2017/03/20 [accepted]
AID - emi201730 [pii]
AID - 10.1038/emi.2017.30 [doi]
PST - epublish
SO  - Emerg Microbes Infect. 2017 Apr 12;6(4):e22. doi: 10.1038/emi.2017.30.

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