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Polymorphisms of Mannose-binding Lectin and Toll-like Receptors 2, 3, 4, 7 and 8 and the Risk of Respiratory Infections and Acute Otitis Media in Children.

Abstract Mannose-binding lectin (MBL) and toll-like receptors (TLRs) are important components of the innate immune system. We assessed the susceptibility of children with genetic variants in these factors to respiratory infections, rhinovirus infections and acute otitis media.
PMID
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Polymorphisms of Mannose-Binding Lectin and Toll-Like Receptors 2, 3, 4, 7, and 8 and the Risk of Respiratory Infections and Acute Otitis Media in Children.

Authors

Mayor MeshTerms
Keywords
Journal Title the pediatric infectious disease journal
Publication Year Start




PMID- 28403045
OWN - NLM
STAT- MEDLINE
DA  - 20170413
DCOM- 20170420
LR  - 20170420
IS  - 1532-0987 (Electronic)
IS  - 0891-3668 (Linking)
VI  - 36
IP  - 5
DP  - 2017 May
TI  - Polymorphisms of Mannose-binding Lectin and Toll-like Receptors 2, 3, 4, 7 and 8 
      and the Risk of Respiratory Infections and Acute Otitis Media in Children.
PG  - e114-e122
LID - 10.1097/INF.0000000000001479 [doi]
AB  - BACKGROUND: Mannose-binding lectin (MBL) and toll-like receptors (TLRs) are
      important components of the innate immune system. We assessed the susceptibility 
      of children with genetic variants in these factors to respiratory infections,
      rhinovirus infections and acute otitis media. METHODS: In a prospective cohort
      study, blood samples from 381 Finnish children were analyzed for polymorphisms in
      MBL2 at codons 52, 54 and 57, TLR2 Arg753Gln, TLR3 Leu412Phe, TLR4 Asp299Gly,
      TLR7 Gln11Leu and TLR8 Leu651Leu. Children were followed up for respiratory
      infections until 24 months of age with daily diaries. Polymerase chain reaction
      and antigen tests were used for detection of respiratory viruses from nasal
      swabs. RESULTS: Children with MBL variant genotype had a mean of 59 days with
      symptoms of respiratory infection per year, compared with 49 days in those with
      wild-type (P = 0.01). TLR8 polymorphisms were associated with an increased risk
      and TLR7 polymorphisms with a decreased risk of recurrent rhinovirus infections
      (P = 0.02 for both). TLR2 polymorphisms were associated with recurrent acute
      otitis media (P = 0.02). MBL polymorphisms were associated with an increased and 
      TLR7 polymorphisms with a decreased risk of rhinovirus-associated acute otitis
      media (P = 0.03 and P = 0.006, respectively). CONCLUSIONS: Genetic polymorphisms 
      in MBL and TLRs promote susceptibility to or protection against respiratory
      infections. In addition to environmental factors, genetic variations may explain 
      why some children are more prone to respiratory infections.
FAU - Toivonen, Laura
AU  - Toivonen L
AD  - From the *Department of Pediatrics and Adolescent Medicine, Turku University
      Hospital, Turku, Finland; and daggerTurku Institute for Child and Youth Research,
      double daggerDepartment of Medical Microbiology and Immunology, and section
      signDepartment of Virology, University of Turku, Turku, Finland.
FAU - Vuononvirta, Juho
AU  - Vuononvirta J
FAU - Mertsola, Jussi
AU  - Mertsola J
FAU - Waris, Matti
AU  - Waris M
FAU - He, Qiushui
AU  - He Q
FAU - Peltola, Ville
AU  - Peltola V
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
RN  - 0 (MBL2 protein, human)
RN  - 0 (Mannose-Binding Lectin)
RN  - 0 (TLR2 protein, human)
RN  - 0 (TLR3 protein, human)
RN  - 0 (TLR4 protein, human)
RN  - 0 (TLR7 protein, human)
RN  - 0 (TLR8 protein, human)
RN  - 0 (Toll-Like Receptor 2)
RN  - 0 (Toll-Like Receptor 3)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Toll-Like Receptor 7)
RN  - 0 (Toll-Like Receptor 8)
SB  - IM
MH  - Child, Preschool
MH  - Female
MH  - Gene Expression
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Immunity, Innate
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Mannose-Binding Lectin/*genetics/immunology
MH  - Otitis Media/diagnosis/*genetics/immunology/pathology
MH  - Polymorphism, Single Nucleotide
MH  - Prospective Studies
MH  - Recurrence
MH  - Respiratory Tract Infections/diagnosis/*genetics/immunology/pathology
MH  - Toll-Like Receptor 2/*genetics/immunology
MH  - Toll-Like Receptor 3/genetics/immunology
MH  - Toll-Like Receptor 4/genetics/immunology
MH  - Toll-Like Receptor 7/*genetics/immunology
MH  - Toll-Like Receptor 8/*genetics
EDAT- 2017/04/14 06:00
MHDA- 2017/04/21 06:00
CRDT- 2017/04/14 06:00
AID - 10.1097/INF.0000000000001479 [doi]
AID - 00006454-201705000-00002 [pii]
PST - ppublish
SO  - Pediatr Infect Dis J. 2017 May;36(5):e114-e122. doi:
      10.1097/INF.0000000000001479.

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