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Prevalence of Cryptosporidium Carriage and Disease in Children With Primary Immune Deficiencies Undergoing Hematopoietic Stem Cell Transplant in Northern Europe.

Abstract A prospective cohort study of children with primary immunodeficiencies undergoing hematopoietic stem cell transplant in the United Kingdom investigated the extent and significance of Cryptosporidium carriage in this high risk group. Three of 42 children recruited were infected with Cryptosporidium, a lower proportion than previously described. One had serious disease. The underlying immunodeficiency likely had a bearing on the clinical presentation and possible outcome of infection.
PMID
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Prevalence of Cryptosporidium Carriage and Disease in Children with Primary Immune-Deficiencies Undergoing Hematopoietic Stem Cell Transplant in Northern Europe.

Authors

Mayor MeshTerms

Hematopoietic Stem Cell Transplantation

Keywords
Journal Title the pediatric infectious disease journal
Publication Year Start




PMID- 28403054
OWN - NLM
STAT- MEDLINE
DA  - 20170413
DCOM- 20170420
LR  - 20170420
IS  - 1532-0987 (Electronic)
IS  - 0891-3668 (Linking)
VI  - 36
IP  - 5
DP  - 2017 May
TI  - Prevalence of Cryptosporidium Carriage and Disease in Children With Primary
      Immune Deficiencies Undergoing Hematopoietic Stem Cell Transplant in Northern
      Europe.
PG  - 504-506
LID - 10.1097/INF.0000000000001517 [doi]
AB  - A prospective cohort study of children with primary immunodeficiencies undergoing
      hematopoietic stem cell transplant in the United Kingdom investigated the extent 
      and significance of Cryptosporidium carriage in this high risk group. Three of 42
      children recruited were infected with Cryptosporidium, a lower proportion than
      previously described. One had serious disease. The underlying immunodeficiency
      likely had a bearing on the clinical presentation and possible outcome of
      infection.
FAU - Davies, Angharad P
AU  - Davies AP
AD  - From the *Swansea University Medical School, Singleton Park, Swansea, United
      Kingdom; daggerCryptosporidium Reference Unit, Public Health Wales Microbiology
      Swansea, Singleton Hospital, Sketty Lane, Swansea, United Kingdom; double
      daggerPaediatric Immunology Department, Great North Children's Hospital, Queen
      Victoria Road, Newcastle upon Tyne, United Kingdom; section signInstitute of
      Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; and
      paragraph signCentre for Immunodeficiency, Institute of Child Health, University 
      College London and Great Ormond Street Hospital, London, United Kingdom.
FAU - Slatter, Mary
AU  - Slatter M
FAU - Gennery, Andrew R
AU  - Gennery AR
FAU - Robinson, Guy
AU  - Robinson G
FAU - Crouch, Nigel
AU  - Crouch N
FAU - Elwin, Kristin
AU  - Elwin K
FAU - Hadfield, Stephen J
AU  - Hadfield SJ
FAU - Cant, Andrew J
AU  - Cant AJ
FAU - Davies, E Graham
AU  - Davies EG
FAU - Chalmers, Rachel M
AU  - Chalmers RM
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Cryptosporidiosis/*epidemiology/immunology/parasitology/therapy
MH  - Cryptosporidium/growth & development/*isolation & purification
MH  - Europe/epidemiology
MH  - Female
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Immunologic Deficiency Syndromes/*epidemiology/immunology/parasitology/therapy
MH  - Infant
MH  - Male
MH  - Prevalence
MH  - Prospective Studies
EDAT- 2017/04/14 06:00
MHDA- 2017/04/21 06:00
CRDT- 2017/04/14 06:00
AID - 10.1097/INF.0000000000001517 [doi]
AID - 00006454-201705000-00015 [pii]
PST - ppublish
SO  - Pediatr Infect Dis J. 2017 May;36(5):504-506. doi: 10.1097/INF.0000000000001517.

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