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Current Status of Dengue Therapeutics Research and Development.

Abstract Dengue is a significant global health problem. Even though a vaccine against dengue is now available, which is a notable achievement, its long-term protective efficacy against each of the 4 dengue virus serotypes remains to be definitively determined. Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue. This review will provide a brief account of the status of therapeutics research and development for dengue.
PMID
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Authors

Mayor MeshTerms
Keywords

antivirals

dengue

dengue drug discovery

dengue prophylaxis

dengue therapeutics

flavivirus

Journal Title the journal of infectious diseases
Publication Year Start




PMID- 28403438
OWN - NLM
STAT- MEDLINE
DA  - 20170413
DCOM- 20170420
LR  - 20170420
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 215
IP  - suppl_2
DP  - 2017 Mar 01
TI  - Current Status of Dengue Therapeutics Research and Development.
PG  - S96-S102
LID - 10.1093/infdis/jiw423 [doi]
AB  - Dengue is a significant global health problem. Even though a vaccine against
      dengue is now available, which is a notable achievement, its long-term protective
      efficacy against each of the 4 dengue virus serotypes remains to be definitively 
      determined. Consequently, drugs directed at the viral targets or critical host
      mechanisms that can be used safely as prophylaxis or treatment to effectively
      ameliorate disease or reduce disease severity and fatalities are still needed to 
      reduce the burden of dengue. This review will provide a brief account of the
      status of therapeutics research and development for dengue.
CI  - (c) The Author 2016. Published by Oxford University Press for the Infectious
      Diseases Society of America.
FAU - Low, Jenny G H
AU  - Low JG
AD  - Department of Infectious Diseases, Singapore General Hospital.
FAU - Ooi, Eng Eong
AU  - Ooi EE
AD  - Programme in Emerging Infectious Diseases, Duke-National University of Singapore 
      Medical School.
AD  - Department of Microbiology and Immunology, National University of Singapore.
AD  - Singapore MIT Alliance in Research and Technology Infectious Diseases
      Interdisciplinary Research Group.
FAU - Vasudevan, Subhash G
AU  - Vasudevan SG
AD  - Programme in Emerging Infectious Diseases, Duke-National University of Singapore 
      Medical School.
AD  - Department of Microbiology and Immunology, National University of Singapore.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antiviral Agents)
SB  - AIM
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/*pharmacology/therapeutic use
MH  - Antiviral Agents/*pharmacology/therapeutic use
MH  - Dengue/*drug therapy/prevention & control
MH  - Drug Discovery
MH  - Humans
OTO - NOTNLM
OT  - *antivirals
OT  - *dengue
OT  - *dengue drug discovery
OT  - *dengue prophylaxis
OT  - *dengue therapeutics
OT  - *flavivirus
EDAT- 2017/04/14 06:00
MHDA- 2017/04/14 06:00
CRDT- 2017/04/14 06:00
AID - 3574515 [pii]
AID - 10.1093/infdis/jiw423 [doi]
PST - ppublish
SO  - J Infect Dis. 2017 Mar 1;215(suppl_2):S96-S102. doi: 10.1093/infdis/jiw423.

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